Temperature and nitric oxide control spontaneous calcium transients in astrocytes.

Abstract:

:Transient spontaneous increases in the intracellular Ca2+ concentration have been frequently observed in astrocytes in cell culture and in acutely isolated slices from several brain regions. Recent in vivo experiments, however, reported only a low frequency of spontaneous Ca2+ events in astrocytes. Since the ex vivo experiments were usually performed at temperatures lower than physiological body temperature, we addressed the question whether temperature could influence the spontaneous Ca2+ activity in astrocytes. Indeed, comparing the frequency and spike width of spontaneous Ca2+ transients in astrocytes at temperatures between 20 and 37 degrees C in culture as well as in acute cortical slices from mouse brain, revealed that spontaneous Ca2+ responses occurred frequently at low temperature and became less frequent at higher temperature. Moreover, the single Ca2+ events had a longer duration at low temperature. We found that nitric oxide (NO) mimicked the increase in spontaneous Ca2+ activity and that an NO-synthase inhibitor attenuated the effect of lowering the temperature. Thus, temperature and NO are major determinants of spontaneous astrocytic Ca2+ signalling.

journal_name

Cell Calcium

journal_title

Cell calcium

authors

Schipke CG,Heidemann A,Skupin A,Peters O,Falcke M,Kettenmann H

doi

10.1016/j.ceca.2007.06.002

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

285-95

issue

3

eissn

0143-4160

issn

1532-1991

pii

S0143-4160(07)00127-3

journal_volume

43

pub_type

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