Abstract：
:R24571 a derivative of the antimycotic miconazole, appears to be 5 to 8 times more potent than trifluoperazine in its ability to inhibit the calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum vesicles. The cAMP-dependent protein kinase mediated phosphorylation of cardiac sarcoplasmic reticulum was not affected by R24571. Sarcoplasmic reticulum Ca-dependent ATPase phosphoprotein intermediate formation was inhibited by R24571 concentrations that were 20 to 30 times greater than those required to inhibit calmodulin-dependent phosphorylation. However, both Ca-dependent and independent ATPase activities, as well as calcium uptake, were inhibited by R24571 concentrations that were similar to, or less than, those concentrations required to inhibit calmodulin-dependent sarcoplasmic reticulum phosphorylation. These results indicate the caution that should be exercised in using this new compound in assessing the possible involvement of calmodulin in other membrane processes.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Louis CF,Turnquist J,Jarvis Bdoi
10.1016/0143-4160(83)90039-8subject
Has Abstractpub_date
1983-04-01 00:00:00pages
107-16issue
2eissn
0143-4160issn
1532-1991pii
0143-4160(83)90039-8journal_volume
4pub_type
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