Abstract：
:Hepatocytes stimulated with calcium-mobilising agonists generate free Ca transients whose frequency is modulated by hormone concentration. Importantly, the time-course of individual free Ca transients is independent of agonist dose but does change with agonist species. A receptor-controlled model in which protein kinase C provides negative feedback directed against the different receptors, or receptor-specific G proteins, has been proposed in order to explain the agonist-specificity of the falling phase of the free Ca spikes. Here we show further evidence, from mixing of hormones and from the effects of elevated cAMP, of receptor-specific information within the spikes.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Cobbold PH,Sanchez-Bueno A,Dixon CJdoi
10.1016/0143-4160(91)90011-3subject
Has Abstractpub_date
1991-02-01 00:00:00pages
87-95issue
2-3eissn
0143-4160issn
1532-1991pii
0143-4160(91)90011-3journal_volume
12pub_type
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