Calibration of the calcium dissociation constant of Rhod(2)in the perfused mouse heart using manganese quenching.

abstract：:We investigated whether the expression of human alpha-parvalbumin affects depolarization-induced elevations of the cytosolic free calcium concentration ([Ca2+]i) in human neuroblastoma SKNBE2 cells. A full length human parvalbumin cDNA was cloned by PCR from human cerebellum and transiently transfected into SKNBE2 cel...

journal_title：Cell calcium

authors： Dreessen J,Lutum C,Schäfer BW,Heizmann CW,Knöpfel T

更新日期：1996-06-01 00:00:00

abstract：:In many animals, a rise in intracellular calcium levels is the trigger for egg activation, the process by which an arrested mature oocyte transitions to prepare for embryogenesis. In nearly all animals studied to date, this calcium rise, and thus egg activation, is triggered by the fertilizing sperm. However in the in...

journal_title：Cell calcium

authors： Sartain CV,Wolfner MF

更新日期：2013-01-01 00:00:00

abstract：:Ca2+ pumps are essential for removing cytosolic Ca2+ either across the plasma membrane (PM) or into internal organelles such as the sarcoplasmic reticulum (SR). Four genes (PMCA1, PMCA2, PMCA3 and PMCA4) have been reported to encode the PM Ca2+ pumps and three (SERCA1, SERCA2 and SERCA3) to encode the SR Ca2+ pumps. T...

journal_title：Cell calcium

authors： Grover AK,Khan I

更新日期：1992-01-01 00:00:00

abstract：:We studied the contribution of store-operated or capacitative Ca2+-entry (SOCE or CCE, respectively) through store-operated Ca2+ channels (SOCCs) and the contribution of Ca2+-entry through receptor-operated, non-selective cation channels (ROCCs or NSCCs, respectively), on the M3-receptor-mediated (270 nM Ach) contract...

journal_title：Cell calcium

authors： Weirich J,Dumont L,Fleckenstein-Grün G

更新日期：2005-11-01 00:00:00

abstract：:There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol...

journal_title：Cell calcium

authors： Taggart MJ,Wray S

更新日期：1997-11-01 00:00:00

abstract：:A 106 kD protein was isolated from skeletal sarcoplasmic reticulum (SR) vesicles and shown to have the properties of SR Ca2+ release channels, including blockade by 5 nM ryanodine. In view of extensive reports that the ryanodine-receptor complex consists of four 565 kD junctional feet proteins (JFPs) and is the 'physi...

journal_title：Cell calcium

authors： Salama G,Nigam M,Shome K,Finkel MS,Lagenaur C,Zaidi NF

更新日期：1992-11-01 00:00:00

abstract：:Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting synaptic plasticity--a neuronal response presumably correlated with cognitive brain functions t...

journal_title：Cell calcium

authors： Carrasco MA,Hidalgo C

更新日期：2006-11-01 00:00:00

abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...

journal_title：Cell calcium

authors： Ong HL,Ambudkar IS

更新日期：2015-10-01 00:00:00

abstract：:It is well established that intracellular calcium ([Ca2+]i) controls the inotropic state of the myocardium, and evidence mounts that a "Ca2+ clock" controls the chronotropic state of the heart. Recent findings describe a calcium-activated nonselective cation channel (NSCCa) in various cardiac preparations sharing hall...

journal_title：Cell calcium

authors： Burt R,Graves BM,Gao M,Li C,Williams DL,Fregoso SP,Hoover DB,Li Y,Wright GL,Wondergem R

更新日期：2013-09-01 00:00:00

abstract：:One of the important events during hypoxia or ischemia in the brain (or other organs for that matter, including the myocardium) is the accumulation of Ca2+ ions intracellularly. Although various studies have shown various sources of and routes for Ca2+ entry and accumulation, it is clear now that it is likely that the...

journal_title：Cell calcium

authors： Yao H,Haddad GG

更新日期：2004-09-01 00:00:00

abstract：:The lungs as the gateways of our body to the external environment are essential for gas exchange. They are also exposed to toxicants from two sides, the airways and the vasculature. Apart from naturally produced toxic agents, millions of human made chemicals were produced since the beginning of the industrial revoluti...

journal_title：Cell calcium

authors： Dietrich A,Steinritz D,Gudermann T

更新日期：2017-11-01 00:00:00

abstract：:We have used single cell fluorescence imaging techniques to examine how functional properties of the caffeine-sensitive Ca(2+) store change during differentiation of a sub-population of caffeine-sensitive SH-SY5Y cells. Application of caffeine (30 mM) 1-10.5 min after a 'priming' depolarisation pulse of 55 mM K(+) rev...

journal_title：Cell calcium

authors： Riddoch FC,Brown AM,Rowbotham SE,Redfern CP,Cheek TR

更新日期：2007-03-01 00:00:00

abstract：:The peptide of HIV-1 envelope gp41 (a.a 628-683), referred to herein as P5, contains P1, a conserved galactose-specific lectin domain for binding the mucosal HIV-1-receptor, galactosyl ceramide (GalCer), as shown earlier, and a potential calcium-binding site (a.a 628-648). P1 contains contiguous epitopes recognized by...

journal_title：Cell calcium

authors： Yu H,Alfsen A,Tudor D,Bomsel M

更新日期：2008-01-01 00:00:00

abstract：:Using whole cell patch clamp recordings on unfertilized eggs of the ascidian Ciona intestinalis, we are able to detect ryanodine receptors within the oocytes. Our approach is based on measurements of the voltage-activated inward calcium currents. Two types of Ca2+ currents have been described on the oocyte membrane of...

journal_title：Cell calcium

authors： Arnoult C,Albrieux M,Antoine AF,Grunwald D,Marty I,Villaz M

更新日期：1997-02-01 00:00:00

abstract：:Animals have evolved sophisticated physiological systems for sensing ambient temperature since changes in environmental temperatures affect various biological processes. Thermosensitive transient receptor potential (thermoTRP) channels serve as thermal sensors in diverse animal species. They are multimodal receptors t...

journal_title：Cell calcium

authors： Saito S,Tominaga M

更新日期：2015-03-01 00:00:00

abstract：:Cellular calcium signaling events are transient. Hence they are observed in real time using fluorescence imaging or electrophysiological methods that require sophisticated instrumentation and specialized skills. For high throughput assays simple and inexpensive techniques are desirable. Many calcium channels that serv...

journal_title：Cell calcium

authors： Chandrika AR,Steephan M,Raveendran Nair R,Sudarsana Devi SP,Kumar M,Paul S,Madhavan M,Omkumar RV

更新日期：2018-09-01 00:00:00

abstract：:T-type Ca(2+) channel family includes three subunits Ca(V)3.1, Ca(V)3.2 and Ca(V)3.3 and have been shown to control burst firing and intracellular Ca(2+) concentration ([Ca(2+)](i)) in neurons. Here, we investigated whether Ca(V)3.1 channels could generate a pacemaker current and contribute to cell excitability. Ca(V)...

journal_title：Cell calcium

authors： Chevalier M,Mironneau C,Macrez N,Quignard JF

更新日期：2008-12-01 00:00:00

abstract：:There is growing evidence indicating that the pore structure of voltage-gated ion channels (VGICs) influences gating besides their conductance. Regarding low voltage-activated (LVA) Ca2+ channels, it has been demonstrated that substitutions of the pore aspartate (D) by a glutamate (D-to-E substitution) in domains III ...

journal_title：Cell calcium

authors： Garza-López E,Aldana A,Darszon A,Nishigaki T,López-González I

更新日期：2020-07-01 00:00:00

abstract：:Three decades ago, James W. Putney Jr. conceptualized the idea of store-operated calcium entry (SOCE) to explain how depletion of endoplasmic reticulum (ER) Ca2+ stores evokes Ca2+ influx across the plasma membrane. Since the publication of this highly influential idea, it is now established that SOCE is universal amo...

journal_title：Cell calcium

authors： Yeung PS,Yamashita M,Prakriya M

更新日期：2017-05-01 00:00:00

abstract：:Calcium and redox signals are presently established as essential regulators of many cellular processes. Nevertheless, we are still far from fully understanding the physiological and pathological importance of these universal second messengers. It is becoming increasingly apparent that many cellular functions are not r...

journal_title：Cell calcium

authors： Gibhardt CS,Zimmermann KM,Zhang X,Belousov VV,Bogeski I

更新日期：2016-08-01 00:00:00

abstract：:The actions of crude venom from Anemesia species of spider were investigated in cultured dorsal root ganglion neurones from neonatal rats and hippocampal slices. Using mass spectrometry (MALDI-TOF MS), 10-12 distinct peptides with masses between about 3 and 10kDa were identified in the crude spider venom. At a concent...

journal_title：Cell calcium

authors： Kalikulov D,Ayar A,Nuritova F,Frenguelli BG,McClelland D,Martin DJ,Davidson I,Scott RH

更新日期：2001-09-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:TRPC channels are a subset of the transient receptor potential (TRP) proteins widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium or sodium entry and have broad-ranging functions that include regulation of cell proliferation, motility and contraction. The channels do n...

journal_title：Cell calcium

authors： Beech DJ,Bahnasi YM,Dedman AM,Al-Shawaf E

更新日期：2009-06-01 00:00:00

abstract：:The non-selective second messenger-gated cation channel TRPC6 (transient receptor potential canonical 6) is activated by diacylglycerols (DAG) in a PKC-independent manner and plays important roles in a variety of physiological processes and diseases. In order to facilitate novel therapies, the development of potent in...

journal_title：Cell calcium

authors： Häfner S,Urban N,Schaefer M

更新日期：2019-03-01 00:00:00

abstract：:Receptor-activated cytoplasmic calcium (Ca2+) oscillations have been investigated in single pancreatic acinar cells by microfluorimetry (Fura-2 as indicator). At submaximal concentrations of the agonists acetylcholine (ACh) and cholecystokinin octapeptide (CCK-8), both give rise to oscillatory changes in the cytosolic...

journal_title：Cell calcium

authors： Yule DI,Lawrie AM,Gallacher DV

更新日期：1991-02-01 00:00:00

abstract：:Calcium entry from the extracellular space into cells is an important signaling mechanism in both physiological and pathophysiological functions. In non-excitable cells, store-operated calcium (SOC) entry represents a principal mode of calcium entry. Activation of SOC entry in pulmonary artery endothelial cells leads ...

journal_title：Cell calcium

authors： Kadeba PI,Vasauskas AA,Chen H,Wu S,Scammell JG,Cioffi DL

更新日期：2013-04-01 00:00:00

abstract：:Calbindin D28K (formerly known as vitamin D-dependent calcium binding protein and referred to here as calbindin) is found in a wide variety of tissues, but only in certain cells within those tissues. Apart from its ability to bind calcium, nothing is known about its function in these cells. To investigate its role we ...

journal_title：Cell calcium

authors： Muir EM,Lawson DE,Sepúlveda FV,O'Brien JA,Harding M

更新日期：1993-04-01 00:00:00

abstract：:Several proteins have been identified that associate with calcium release channels and potentially regulate their function. Using tacrolimus as a pharmacological tool, we investigated whether the immunophilin FKBP12 modulates ryanodine receptor channels in intestinal smooth muscle. Results with PCR demonstrated the pr...

journal_title：Cell calcium

authors： Bielefeldt K,Sharma RV,Whiteis C,Yedidag E,Abboud FM

更新日期：1997-12-01 00:00:00

abstract：:Store-operated Ca2+ entry (SOCE), an important Ca2+ signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. H...

journal_title：Cell calcium

authors： Bittremieux M,Gerasimenko JV,Schuermans M,Luyten T,Stapleton E,Alzayady KJ,De Smedt H,Yule DI,Mikoshiba K,Vangheluwe P,Gerasimenko OV,Parys JB,Bultynck G

更新日期：2017-03-01 00:00:00

abstract：:Relative to mammals, the neuroendocrine control of pituitary growth hormone (GH) secretion and synthesis in teleost fish involves numerous stimulatory and inhibitory regulators, many of which are delivered to the somatotrophs via direct innervation. Among teleosts, how multifactorial regulation of somatotroph function...

journal_title：Cell calcium

authors： Chang JP,Habibi HR,Yu Y,Moussavi M,Grey CL,Pemberton JG

更新日期：2012-03-01 00:00:00