The role of the calcium-sensing receptor in epidermal differentiation.

abstract：:The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by Ca...

journal_title：Cell calcium

authors： Xu L,Gomez AC,Pasek DA,Meissner G,Yamaguchi N

更新日期：2017-09-01 00:00:00

abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...

journal_title：Cell calcium

authors： Samtleben S,Wachter B,Blum R

更新日期：2015-08-01 00:00:00

abstract：:In murine ventricular myocytes, activation of mechanosensitive ion channels (MSCs) includes activation of non-selective cation currents and deactivation of inwardly rectifying potassium currents. Using pharmacological inhibitors and knockout models, we analyzed signaling steps that are critical to transduce the mechan...

journal_title：Cell calcium

authors： Dyachenko V,Rueckschloss U,Isenberg G

更新日期：2009-01-01 00:00:00

abstract：:Cellular Ca2+ signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca2+ channels cause large fluctuations in local Ca2+ concentration (Ca2+ 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca2+-sensitive probes from attoliter volumes it has become poss...

journal_title：Cell calcium

authors： Swaminathan D,Dickinson GD,Demuro A,Parker I

更新日期：2020-03-01 00:00:00

abstract：:TRP family of proteins are components of unique cation channels that are activated in response to diverse stimuli ranging from growth factor and neurotransmitter stimulation of plasma membrane receptors to a variety of chemical and sensory signals. This review will focus on members of the TRPC sub-family (TRPC1-TRPC7)...

journal_title：Cell calcium

authors： Ambudkar IS,Bandyopadhyay BC,Liu X,Lockwich TP,Paria B,Ong HL

更新日期：2006-11-01 00:00:00

abstract：:In addition to its role in artery contraction, Rho kinase (ROCK) is reported to be involved in the Ca(2+) response to vasoconstrictor agonist in rat aorta. However the signaling pathway mediated by ROCK had not been investigated so far and it was not known whether ROCK also contributed to Ca(2+) signaling in cultured ...

journal_title：Cell calcium

authors： Martinsen A,Baeyens N,Yerna X,Morel N

更新日期：2012-12-01 00:00:00

abstract：:TRPC channels are a subset of the transient receptor potential (TRP) proteins widely expressed in mammalian cells. They are thought to be primarily involved in determining calcium or sodium entry and have broad-ranging functions that include regulation of cell proliferation, motility and contraction. The channels do n...

journal_title：Cell calcium

authors： Beech DJ,Bahnasi YM,Dedman AM,Al-Shawaf E

更新日期：2009-06-01 00:00:00

abstract：:Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of neuronal circuit function, structure and molecular composition in the brain of awake behaving adult mice. Thus, mice have become a crit...

journal_title：Cell calcium

authors： Radulescu CI,Cerar V,Haslehurst P,Kopanitsa M,Barnes SJ

更新日期：2021-01-23 00:00:00

abstract：:Calbindin D28K (formerly known as vitamin D-dependent calcium binding protein and referred to here as calbindin) is found in a wide variety of tissues, but only in certain cells within those tissues. Apart from its ability to bind calcium, nothing is known about its function in these cells. To investigate its role we ...

journal_title：Cell calcium

authors： Muir EM,Lawson DE,Sepúlveda FV,O'Brien JA,Harding M

更新日期：1993-04-01 00:00:00

abstract：:In salivary acinar cells, muscarinic-induced fluid secretion is associated with a 1,4,5-IP3 induced increase in the cytosolic free Ca2+ concentration ([Ca2+]i), which in turn activates Ca(2+)-dependent K+ and Cl- channels that modulate the membrane potential. In the present study the influence of the membrane potentia...

journal_title：Cell calcium

authors： Zhang GH,Melvin JE

更新日期：1993-07-01 00:00:00

abstract：:Dopamine is one of the key neurotransmitters in the central nervous system and plays an important role in physiological processes, as well as in the development of many diseases. Here we report a receptor-independent signalling pathway induced by dopamine in CNS neurons. In cultured neurons from midbrain, cortex and h...

journal_title：Cell calcium

authors： Vaarmann A,Gandhi S,Gourine AV,Abramov AY

更新日期：2010-08-01 00:00:00

abstract：:Here we examine the potential coupling between the synthesis of secretory proteins and the sensitivity of exocytosis to the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)) in plant cell. We therefore monitor in tobacco protoplasts the excursion of the membrane capacitance in response to an elevation of [Ca(2...

journal_title：Cell calcium

authors： Sutter JU,Denecke J,Thiel G

更新日期：2012-09-01 00:00:00

abstract：:Changes in the concentration and spatial distribution of Ca(2+) ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca(2+) dyes that allow direct visualization of Ca(2+) transients, combined with powerful experimental tools such as electrophysiologica...

journal_title：Cell calcium

authors： Machaca K

更新日期：2010-11-01 00:00:00

abstract：:The Solute Carrier Family 24 (SLC24) belongs to the CaCA super family of Ca(2+)/cation antiporters and codes for five different K(+)- dependent Na(+)- Ca(2+) exchangers (NCKX1-5). NCKX proteins play a critical role in Ca(2+) homeostasis in a wide variety of biological processes such as vision, olfaction, enamel format...

journal_title：Cell calcium

authors： Jalloul AH,Szerencsei RT,Schnetkamp PP

更新日期：2016-01-01 00:00:00

abstract：:We studied the contribution of store-operated or capacitative Ca2+-entry (SOCE or CCE, respectively) through store-operated Ca2+ channels (SOCCs) and the contribution of Ca2+-entry through receptor-operated, non-selective cation channels (ROCCs or NSCCs, respectively), on the M3-receptor-mediated (270 nM Ach) contract...

journal_title：Cell calcium

authors： Weirich J,Dumont L,Fleckenstein-Grün G

更新日期：2005-11-01 00:00:00

abstract：:Isolated avian growth plate chondrocytes convert the acetoxymethyl ester (AM) form of Fura-2 quickly and efficiently to the Ca2(+)-sensitive pentacarboxylic acid (FA) form. Control experiments indicate that the Kd for intracellular Fura-2/FA is very close to that of extracellular Fura-2/FA at the same ionic strength a...

journal_title：Cell calcium

authors： Gunter TE,Zuscik MJ,Puzas JE,Gunter KK,Rosier RN

更新日期：1990-08-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:The lack of specific inhibitors of the plasma membrane Ca2+ pump (PMCA) has made vanadate (VO3-), a non-specific inhibitor, an invaluable tool in the study of PMCA function. However, three important properties of vanadate as an inhibitor of the PMCA in intact cells, namely its speed of action in different experimental...

journal_title：Cell calcium

authors： Tiffert T,Lew VL

更新日期：2001-11-01 00:00:00

abstract：:C3H/10T1/2 mouse embryo fibroblasts stimulated by a steady electric field (10 V/cm) for 30 min exhibited lamellar retraction on the sides facing the electrodes. Some cells elongated and preferentially oriented with their long axis perpendicular to the field direction. Depletion of external calcium or blockage of calci...

journal_title：Cell calcium

authors： Onuma EK,Hui SW

更新日期：1985-06-01 00:00:00

abstract：:Light-sensitive channels encoded by the Drosophila transient receptor potential-like gene (trpl) are activated in situ by an unknown mechanism requiring activation of Gq and phospholipase C (PLC). Recent studies have variously concluded that heterologously expressed TRPL channels are activated by direct Gq-protein int...

journal_title：Cell calcium

authors： Hardie RC,Raghu P

更新日期：1998-09-01 00:00:00

abstract：:Cultured rat cerebellar astrocytes, loaded with the Ca2+-sensitive fluorescent dyes Fura-2 or Fluo-3, responded with cytoplasmic Ca2+ transients, when the external K+ concentration was reduced from 5 mM to below 1 mM. Ca2+ transients were generated after changing to a saline containing 0.2 mM K+ in 82% of the cells (n...

journal_title：Cell calcium

authors： Dallwig R,Vitten H,Deitmer JW

更新日期：2000-10-01 00:00:00

abstract：:Intracellular calcium signals activated by growth factors in endothelial cells during angiogenesis regulate cytosolic and nuclear events involved in survival, proliferation and motility. Among the intracellular messengers released after proangiogenic stimulation (bFGF, VEGF), arachidonic acid (AA), nitric oxide (NO) a...

journal_title：Cell calcium

authors： Tomatis C,Fiorio Pla A,Munaron L

更新日期：2007-03-01 00:00:00

abstract：:N,N'-dicyclohexylcarbodiimide (DCCD) and 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide (CMCD) inhibited calmodulin-dependent Ca2(+)+Mg2(+)-ATPase activity in erythrocyte ghost membranes. The extent of the inhibition caused by carbodiimides strongly depended on their hydrophobicity. Hydrophobic DCCD was a more potent...

journal_title：Cell calcium

authors： Famulski KS,Pikula S,Wrzosek A,Wojtczak AB

更新日期：1990-04-01 00:00:00

abstract：:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...

journal_title：Cell calcium

authors： Pavlovic D

更新日期：2020-03-01 00:00:00

abstract：:Evidence is accumulating on a key role of T-type channels in neurotransmitter release. Recent works have brought undisputable proofs that T-type channels are capable of controlling hormone and neurotransmitters release in association with exocytosis of large dense-core and synaptic vesicles. T-type channel-secretion c...

journal_title：Cell calcium

authors： Carbone E,Giancippoli A,Marcantoni A,Guido D,Carabelli V

更新日期：2006-08-01 00:00:00

abstract：:We previously found in single channel studies that ryanodine receptor (RyR) channel activity can be made insensitive to block by Mg2+ when terminal cisternae of sarcoplasmic reticulum, incorporated into planar bilayers, are treated with protein kinase A (PKA) or Ca2+/calmodulin dependent protein kinase type II (CamPK ...

journal_title：Cell calcium

authors： Mayrleitner M,Chandler R,Schindler H,Fleischer S

更新日期：1995-09-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:Within the CNS, distinct neurons may rely on different processes to modulate cytosolic Ca2+ depending on the network developmental phase. In particular, in the immature spinal cord, synchronous electrical discharges are coupled with biochemical signals triggered by intracellular Ca2+ waves. Nevertheless, the presence ...

journal_title：Cell calcium

authors： Fabbro A,Pastore B,Nistri A,Ballerini L

更新日期：2007-04-01 00:00:00

abstract：:The purpose of this study was to invent an extracellular inhibitor selective for the plasma membrane Ca(2+) pump(s) (PMCA) isoform 1. PMCA extrude Ca(2+) from cells during signalling and homeostasis. PMCA isoforms are encoded by 4 genes (PMCA1-4). Pig coronary artery endothelium and smooth muscle express the genes PMC...

journal_title：Cell calcium

authors： Szewczyk MM,Pande J,Akolkar G,Grover AK

更新日期：2010-12-01 00:00:00

abstract：:Store-operated Ca2+ entry (SOCE), an important Ca2+ signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. H...

journal_title：Cell calcium

authors： Bittremieux M,Gerasimenko JV,Schuermans M,Luyten T,Stapleton E,Alzayady KJ,De Smedt H,Yule DI,Mikoshiba K,Vangheluwe P,Gerasimenko OV,Parys JB,Bultynck G

更新日期：2017-03-01 00:00:00