The aging mouse brain: cognition, connectivity and calcium.

Abstract:

:Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of neuronal circuit function, structure and molecular composition in the brain of awake behaving adult mice. Thus, mice have become a critical tool to better understand how aging impacts the brain. However, a more granular systems-based approach, which considers the impact of age on key features relating to neural processing, is required. Here, we review evidence probing the impact of age on the mouse brain. We focus on a range of processes relating to neuronal function, including cognitive abilities, sensory systems, synaptic plasticity and calcium regulation. Across many systems, we find evidence for prominent age-related dysregulation even before 12 months of age, suggesting that emerging age-related alterations can manifest by late adulthood. However, we also find reports suggesting that some processes are remarkably resilient to aging. The evidence suggests that aging does not drive a parallel, linear dysregulation of all systems, but instead impacts some processes earlier, and more severely, than others. We propose that capturing the more fine-scale emerging features of age-related vulnerability and resilience may provide better opportunities for the rejuvenation of the aged brain.

journal_name

Cell Calcium

journal_title

Cell calcium

authors

Radulescu CI,Cerar V,Haslehurst P,Kopanitsa M,Barnes SJ

doi

10.1016/j.ceca.2021.102358

subject

Has Abstract

pub_date

2021-01-23 00:00:00

pages

102358

eissn

0143-4160

issn

1532-1991

pii

S0143-4160(21)00012-9

journal_volume

94

pub_type

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