Abstract:
:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitous transport enzyme sodium potassium pump, thus regulating intracellular Na+ concentration in every living cell, they are also an essential tool for research into the sodium potassium pump structure and function. Exogenous CTS have been clearly demonstrated to affect cardiovascular system through modulation of vagal tone, cardiac contraction (via ionic changes) and altered natriuresis. Reports of a number of endogenous CTS, since the 1980s, have intensified research into their physiologic and pathophysiologic roles and opened up novel therapeutic targets. Substantive evidence pointing to the role of endogenous ouabain and marinobufagenin, the two most prominent CTS, in development of cardiovascular disease has accumulated. Nevertheless, their presence, structure, biosynthesis pathways and even mechanism of action remain unclear or controversial. In this review the current state-of-the-art, the controversies and the remaining questions surrounding the role of endogenous cardiotonic steroids in health and disease are discussed.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Pavlovic Ddoi
10.1016/j.ceca.2019.102156subject
Has Abstractpub_date
2020-03-01 00:00:00pages
102156eissn
0143-4160issn
1532-1991pii
S0143-4160(19)30225-8journal_volume
86pub_type
杂志文章相关文献
CELL CALCIUM文献大全abstract::Using the fluorescent Ca2+ probe Quin-2 it has been reported that cholera toxin (CT) and its B subunit (B-CT) increase cytosolic free Ca2+ concentration ([Ca2+]i) in entherocytes, thymocytes and fibroblasts. In this work we show, however, that the fluorescence increases of Quin-2-loaded cells (rat thymocytes, mouse sp...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(90)90054-x
更新日期:1990-06-01 00:00:00
abstract::The highly differentiated structure of the neuron poses special problems for the intracellular movement of molecules throughout the cell. Molecular transport distances from the synthesizing neuron cell body along the axon (which has no substantial synthetic capabilities) to the axon terminal are very great. The transp...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(88)90010-3
更新日期:1988-12-01 00:00:00
abstract::Quartered pituitaries from castrated (72 h) +/- estradiol (E2)-treated (24 h) rats were used in a perifusion system to investigate estradiol modulation of ionomycin and ionomycin + PMA stimulated LH secretion. Estradiol enhanced the LH responses to GnRH (1 nM) and ionomycin (10 microM), and was necessary for the manif...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(93)90015-x
更新日期:1993-01-01 00:00:00
abstract::When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(90)90008-i
更新日期:1990-04-01 00:00:00
abstract::Cardiac muscle excitation-contraction coupling is controlled by the Ca(2+)-induced Ca2+ release mechanism. The present study examines the effects of a calmodulin antagonist W-7 on Ca2+ current (ICa)-induced Ca2+ release in whole cell-clamped rat ventricular myocytes. Exposure of cells to W-7 suppressed ICa, but the in...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1054/ceca.1998.0019
更新日期:1999-03-01 00:00:00
abstract::Calcium release-activated calcium (CRAC) channels have been the target of drug discovery for many years. The identification of STIM and Orai proteins as key components of CRAC channels greatly facilitated this process because their co-expression in cell lines produced electrophysiological currents (ICRAC) much larger ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.07.005
更新日期:2018-09-01 00:00:00
abstract::A preparation of sea urchin eggs permeabilized with digitonin (40 microM for 2.5 min) was used to study the kinetic characteristics of the two cellular compartments suspected to play a key role in cellular calcium transfer during fertilization: an ATP-dependent Ca2+ pool (Km = 0.47 microM; Vm = 0.48 nmol/min.mg protei...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(91)90003-w
更新日期:1991-04-01 00:00:00
abstract::The mitochondrial permeability transition pore (mPTP) has long been known to have a role in mitochondrial calcium (Ca(2+)) homeostasis under pathological conditions as a mediator of the mitochondrial permeability transition and the activation of the consequent cell death mechanism. However, its role in the context of ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2014.03.004
更新日期:2014-07-01 00:00:00
abstract::Several potentially life-threatening cardiovascular and respiratory disorders result in prolonged deprivation of oxygen, which in turn results in significant cellular adaptation, or remodelling. An important component of this functional adaptation arises as a direct consequence of altered ion channel expression by chr...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2004.02.005
更新日期:2004-09-01 00:00:00
abstract::Using whole cell patch clamp recordings on unfertilized eggs of the ascidian Ciona intestinalis, we are able to detect ryanodine receptors within the oocytes. Our approach is based on measurements of the voltage-activated inward calcium currents. Two types of Ca2+ currents have been described on the oocyte membrane of...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(97)90033-6
更新日期:1997-02-01 00:00:00
abstract::Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2013.02.001
更新日期:2013-05-01 00:00:00
abstract::Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2020.102285
更新日期:2020-11-01 00:00:00
abstract::Corticosteroid hormones, which are released in high amounts after stress, easily pass the blood-brain-barrier. In the brain they bind to intracellular receptors which act as transcriptional regulators. These receptors are highly expressed in neurons of the hippocampal formation and the amygdala, areas that play a role...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2011.11.002
更新日期:2012-03-01 00:00:00
abstract::The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/s0143-4160(96)90108-6
更新日期:1996-08-01 00:00:00
abstract::Human CD3-, CD16+ natural killer cells (NKs) induced necrosis in the cell line K562 and the minor population of MOLT-4, while induced apoptosis in the majority of MOLT-4, in one-to-one cell interaction. Simultaneous Ca2+ imaging of NK and target cells revealed remarkable differences in changes of cytosolic Ca2+ concen...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(96)90070-6
更新日期:1996-04-01 00:00:00
abstract::The store-operated, calcium release-activated calcium current I(CRAC) is activated by the depletion of inositol 1,4,5-trisphosphate (IP(3))-sensitive stores. The significantly different dose-response relationships of IP(3)-mediated Ca(2+) release and CRAC channel activation indicate that I(CRAC) is activated by a func...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2008.12.001
更新日期:2009-04-01 00:00:00
abstract::There is controversy as to whether TRP channels participate in mediating store-operated current (I(SOC)) and store-operated Ca(2+) entry (SOCE). Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle traffick...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2011.08.006
更新日期:2011-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2015.04.002
更新日期:2015-08-01 00:00:00
abstract::Calcium and redox signals are presently established as essential regulators of many cellular processes. Nevertheless, we are still far from fully understanding the physiological and pathological importance of these universal second messengers. It is becoming increasingly apparent that many cellular functions are not r...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.04.008
更新日期:2016-08-01 00:00:00
abstract::An inward current responsible for hormone regulated Ca2+ entry has been identified in cultured rat hepatocytes using whole cell patch clamp. Addition of 20 nM vasopressin or of 100 microM ATP induced the inward current, which could be observed more clearly after blocking an outward K+ current. This large outward K+ cu...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(95)90042-x
更新日期:1995-07-01 00:00:00
abstract::Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2006.04.023
更新日期:2006-08-01 00:00:00
abstract::Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2007.10.003
更新日期:2008-06-01 00:00:00
abstract::The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2009.04.001
更新日期:2009-07-01 00:00:00
abstract::TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as a potent entry point of working desperate diseases out in a new way with newfangled ideas and safer technological means....
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2019.02.011
更新日期:2019-05-01 00:00:00
abstract::Central to controlling intracellular calcium concentration ([Ca(2+)](i)) are a number of Ca(2+) transporters and channels with the L-type Ca(2+) channel, Na(+)-Ca(2+) exchanger and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) being of particular note in the heart. This review concentrates on the regulation of [Ca(2+)]...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2007.04.002
更新日期:2007-10-01 00:00:00
abstract::The Ca2+-sensitive dye quin-2 was used to measure the cytosolic free Ca2+ (Cai2+) in suspensions of ventricular myocytes isolated from cat and rat ventricles. Following an isolation procedure that was similar for both species, the cells were loaded with quin-2 AM (25 microM) for 30 min at 37 degrees C. After two washe...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(87)90002-9
更新日期:1987-08-01 00:00:00
abstract::Maitotoxin (MTX), a water-soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus increased intracellular calcium in a concentration-dependent manner in fibroblasts obtained from human skin. The effect of this toxin was both saturable and of high affinity, showing an apparent half activation co...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(97)90087-7
更新日期:1997-07-01 00:00:00
abstract::Photolysis of caged calcium (Nitr5, Calbiochem) can be used to study calcium dependent processes such as excitation-contraction coupling and muscular mechanics. Expensive high energy light sources are routinely used for UV light exposure, but this study describes an alternative low cost xenon flash unit constructed in...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(94)90017-5
更新日期:1994-05-01 00:00:00
abstract::Calcium ion is involved in diverse physiological and developmental pathways. One of the important roles of calcium is a signaling messenger, which regulates signal transduction in plants. CBL (calcineurin B-like protein) is one of the calcium sensors that specifically interact with a family of serine-threonine protein...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::A whole range of cell functions are regulated by the free cytosolic Ca(2+)concentration. Activator Ca(2+)from the extracellular space enters the cell through various types of Ca(2+)channels and sometimes the Na(+)/Ca(2+)-exchanger, and is actively extruded from the cell by Ca(2+)pumps and Na(+)/Ca(2+)-exchangers. Acti...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1054/ceca.2000.0131
更新日期:2000-07-01 00:00:00