Abstract：
:Maitotoxin (MTX), a water-soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus increased intracellular calcium in a concentration-dependent manner in fibroblasts obtained from human skin. The effect of this toxin was both saturable and of high affinity, showing an apparent half activation constant of 450 fM. The toxin did not release intracellular calcium storage compartments nor did the release of these compartments with thapsigargin or ionomycin affect the toxin response. The toxin effect was reduced significantly by pre-incubating the cells with 0.1% trypsin for 30 min, strongly suggesting that the toxin receptor is a plasmalemmal protein. The effect of MTX was partially inhibited by diphenoxylate.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Gutierrez D,Díaz de León L,Vaca Ldoi
10.1016/s0143-4160(97)90087-7subject
Has Abstractpub_date
1997-07-01 00:00:00pages
31-8issue
1eissn
0143-4160issn
1532-1991pii
S0143-4160(97)90087-7journal_volume
22pub_type
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