Abstract:
:Three decades ago, James W. Putney Jr. conceptualized the idea of store-operated calcium entry (SOCE) to explain how depletion of endoplasmic reticulum (ER) Ca2+ stores evokes Ca2+ influx across the plasma membrane. Since the publication of this highly influential idea, it is now established that SOCE is universal among non-excitable and probably even many types of excitable cells, and contributes to numerous effector functions impacting immunity, muscle contraction, and brain function. The molecules encoding SOCE, the STIM and Orai proteins, are now known and our understanding of how this pathway is activated in response to ER Ca2+ store depletion has advanced significantly. In this review, we summarize the current knowledge of how Orai1 channels are activated by STIM1, focusing on recent work supporting a hydrophobic gating mechanism for the opening of the Orai1 channel pore.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Yeung PS,Yamashita M,Prakriya Mdoi
10.1016/j.ceca.2016.12.006subject
Has Abstractpub_date
2017-05-01 00:00:00pages
14-19eissn
0143-4160issn
1532-1991pii
S0143-4160(16)30212-3journal_volume
63pub_type
杂志文章,评审相关文献
CELL CALCIUM文献大全abstract::Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(96)90113-x
更新日期:1996-05-01 00:00:00
abstract::The sphingosine derivatives sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) caused a similar elevation of the intracellular Ca2+ concentration ([Ca2+]i) in an immortalized airway epithelial cell line (CFNP9o-) incubated in Ca(2+)-free medium. The maximal effect was obtained with 2 microM SPC and 0....
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(98)90095-1
更新日期:1998-06-01 00:00:00
abstract::Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2014.10.014
更新日期:2014-12-01 00:00:00
abstract::Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2006.08.007
更新日期:2006-11-01 00:00:00
abstract::Acidic organelles such as lysosomes serve as non-canonical Ca(2+) stores. The Ca(2+) mobilising messenger NAADP is thought to trigger local Ca(2+) release from such stores. These events are then amplified by Ca(2+) channels on canonical ER Ca(2+) stores to generate physiologically relevant global Ca(2+) signals. Coupl...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2015.03.006
更新日期:2015-10-01 00:00:00
abstract::While genetically encoded Ca(2+) indicators (GECIs) allow Ca(2+) imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the inte...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2011.10.006
更新日期:2012-01-01 00:00:00
abstract::A potential role of arachidonic acid in the modulation of insulin secretion was investigated by measuring its effects on calmodulin-dependent protein kinase and protein kinase C in islet subcellular fractions. The results were interpreted in the light of arachidonic acid effects on insulin secretion from intact islets...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(92)90044-s
更新日期:1992-03-01 00:00:00
abstract::We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(83)90049-0
更新日期:1983-02-01 00:00:00
abstract::We have used single cell fluorescence imaging techniques to examine how functional properties of the caffeine-sensitive Ca(2+) store change during differentiation of a sub-population of caffeine-sensitive SH-SY5Y cells. Application of caffeine (30 mM) 1-10.5 min after a 'priming' depolarisation pulse of 55 mM K(+) rev...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2006.06.007
更新日期:2007-03-01 00:00:00
abstract::Vesl/Homer proteins physically link proteins that mediate cellular signaling [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851] and thereby influence cellular function [Nat. Neurosci. 4 (2001) 499; Nature 411 (2001) 962]. A previous study reported that Vesl-1L/Homer-1c ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(03)00082-4
更新日期:2003-08-01 00:00:00
abstract::The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling oper...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2014.01.006
更新日期:2014-06-01 00:00:00
abstract::Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+) levels and transducing this cellular signal to Orai1 channel proteins. Our understanding of the molecular mechanisms underlying STIM signaling has been drama...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.04.006
更新日期:2018-07-01 00:00:00
abstract::Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2018.05.003
更新日期:2018-07-01 00:00:00
abstract::A 106 kD protein was isolated from skeletal sarcoplasmic reticulum (SR) vesicles and shown to have the properties of SR Ca2+ release channels, including blockade by 5 nM ryanodine. In view of extensive reports that the ryanodine-receptor complex consists of four 565 kD junctional feet proteins (JFPs) and is the 'physi...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(92)90074-3
更新日期:1992-11-01 00:00:00
abstract::Light-sensitive channels encoded by the Drosophila transient receptor potential-like gene (trpl) are activated in situ by an unknown mechanism requiring activation of Gq and phospholipase C (PLC). Recent studies have variously concluded that heterologously expressed TRPL channels are activated by direct Gq-protein int...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(98)90125-7
更新日期:1998-09-01 00:00:00
abstract::To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms. Utilizing the electrophysiological technique of capacitance measurements as ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(96)90081-0
更新日期:1996-02-01 00:00:00
abstract::The purpose of this study was to invent an extracellular inhibitor selective for the plasma membrane Ca(2+) pump(s) (PMCA) isoform 1. PMCA extrude Ca(2+) from cells during signalling and homeostasis. PMCA isoforms are encoded by 4 genes (PMCA1-4). Pig coronary artery endothelium and smooth muscle express the genes PMC...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2010.10.008
更新日期:2010-12-01 00:00:00
abstract::NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck in this basic research is due to NAADP, like all second messengers, being charged to prevent it from leaking out of cells. This...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2007.08.006
更新日期:2008-06-01 00:00:00
abstract::Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2011.02.001
更新日期:2011-03-01 00:00:00
abstract::There is growing evidence indicating that the pore structure of voltage-gated ion channels (VGICs) influences gating besides their conductance. Regarding low voltage-activated (LVA) Ca2+ channels, it has been demonstrated that substitutions of the pore aspartate (D) by a glutamate (D-to-E substitution) in domains III ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2020.102214
更新日期:2020-07-01 00:00:00
abstract::The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) mediates increases in the intracellular concentration of Ca(2+) ([Ca(2+)]i) during fertilization in mammalian eggs. The activity of IP3R1 is enhanced during oocyte maturation, and phosphorylations by M-phase kinases are thought to positively regulate the activit...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2015.07.004
更新日期:2015-11-01 00:00:00
abstract::Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and envir...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2011.08.003
更新日期:2011-11-01 00:00:00
abstract::The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. In...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(95)90111-6
更新日期:1995-05-01 00:00:00
abstract::Localized subcellular changes in Ca(2+) serve as important cellular signaling elements, regulating processes as diverse as neuronal excitability and gene expression. Studies of cellular Ca(2+) signaling have been greatly facilitated by the availability of fluorescent Ca(2+) indicators. The respective merits of differe...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2015.10.003
更新日期:2015-12-01 00:00:00
abstract::Calcium ion is involved in diverse physiological and developmental pathways. One of the important roles of calcium is a signaling messenger, which regulates signal transduction in plants. CBL (calcineurin B-like protein) is one of the calcium sensors that specifically interact with a family of serine-threonine protein...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/0143-4160(86)90042-4
更新日期:1986-12-01 00:00:00
abstract::The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we di...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2011.11.006
更新日期:2012-03-01 00:00:00
abstract::The role of intracellular calcium stores in stimulus-secretion coupling in the pancreatic beta-cell is largely unknown. We report here that tetracaine stimulates insulin secretion from collagenase-isolated mouse islets of Langerhans in the absence of glucose or extracellular calcium. We also found that the anesthetic ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1054/ceca.1998.0007
更新日期:1999-01-01 00:00:00
abstract::Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102156
更新日期:2020-03-01 00:00:00
abstract::Ca2+ signalling governs stimulated exocytosis and exocytosis-coupled endocytosis also in Paramecium cells. Upon stimulation, the < or =10(3) dense-core exocytotic organelles (trichocysts) can be synchronously (80 ms) released, followed by endocytotic membrane resealing (350 ms) and retrieval. Paramecium is the most sy...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2005.06.008
更新日期:2005-09-01 00:00:00