IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC).

abstract：:STIM and Orai isoforms orchestrate store operated Ca2+ entry (SOCE) and thus cytosolic Ca2+ fluctuations following stimulation by hormones, growth factors and further mediators. Orai1 is a target of Nedd4-2, an ubiquitin ligase preparing several plasma membrane proteins for degradation. Phosphorylation of Nedd4-2 by t...

journal_title：Cell calcium

authors： Lang F,Eylenstein A,Shumilina E

更新日期：2012-11-01 00:00:00

abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...

journal_title：Cell calcium

authors： Oheim M,Kirchhoff F,Stühmer W

更新日期：2006-11-01 00:00:00

abstract：:Fluorescent calcium indicators have been widely used to assess cytoplasmic calcium concentration in cells. To examine the role of calcium ions on different physiological functions (e.g. in case of liver; bile secretion, glucose metabolism, etc.) there is a need for whole organ studies. We have developed a technique to...

journal_title：Cell calcium

authors： Ruttner Z,Ligeti L,Reinlib L,Hines K,McLaughlin AC

更新日期：1993-06-01 00:00:00

abstract：:Store-operated Ca2+ entry (SOCE), an important Ca2+ signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. H...

journal_title：Cell calcium

authors： Bittremieux M,Gerasimenko JV,Schuermans M,Luyten T,Stapleton E,Alzayady KJ,De Smedt H,Yule DI,Mikoshiba K,Vangheluwe P,Gerasimenko OV,Parys JB,Bultynck G

更新日期：2017-03-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:The peptide of HIV-1 envelope gp41 (a.a 628-683), referred to herein as P5, contains P1, a conserved galactose-specific lectin domain for binding the mucosal HIV-1-receptor, galactosyl ceramide (GalCer), as shown earlier, and a potential calcium-binding site (a.a 628-648). P1 contains contiguous epitopes recognized by...

journal_title：Cell calcium

authors： Yu H,Alfsen A,Tudor D,Bomsel M

更新日期：2008-01-01 00:00:00

abstract：:The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling oper...

journal_title：Cell calcium

authors： Ahuja M,Jha A,Maléth J,Park S,Muallem S

更新日期：2014-06-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:Ca2+ efflux from dog red blood cells loaded with Ca2+ using the A23187 ionophore could be separated into two main components: (1) Mg- and ATP-dependent (active transport) and (2) dependent on external Na (K1/2 around 15 mM); at 80 microM internal free Ca the relative magnitudes of these fluxes were 70% and 30% respect...

journal_title：Cell calcium

authors： Altamirano AA,Beaugé L

更新日期：1985-12-01 00:00:00

abstract：:Hard end is a physiological disorder of pear fruit that is frequently observed in the 'Whangkeumbae' (Pyrus pyrifolia) variety, however, the mechanisms that are involved in its development are poorly understood. In this study, we explored the causes of hard end disorder in pear fruit in relation to calcium deficiency....

journal_title：Cell calcium

authors： Wang Y,Zhang X,Wang Y,Yang S,Qu H

更新日期：2018-05-01 00:00:00

abstract：:Many fluorescent Ca indicators, particularly those loaded as acetoxymethyl (AM)-ester derivatives, are known to become compartmentalized into organelles. This property can be exploited to measure changes in free [Ca] in subcellular compartments, including the inositol (1,4,5)-trisphosphate-sensitive store. However, qu...

journal_title：Cell calcium

authors： Hofer AM,Schulz I

更新日期：1996-09-01 00:00:00

abstract：:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...

journal_title：Cell calcium

authors： Pavlovic D

更新日期：2020-03-01 00:00:00

abstract：:Apparent calcium stability constants and the purity of Ca-chelating agents were evaluated using Ca(2+)-selective electrodes by the double-log optimization method [Oiki S. Yamamoto T. Okada Y. (1994) Cell Calcium, 15, 199-208]. The method was amended to allow evaluation of the free Ca2+ concentrations contaminating ele...

journal_title：Cell calcium

authors： Oiki S,Yamamoto T,Okada Y

更新日期：1994-03-01 00:00:00

abstract：:An initial model has been proposed to describe a mechanism for cytosolic calcium oscillations [Jafri MS. Vajda S. Pasik P. Gillo B. (1992) A membrane model for cytosolic calcium oscillations: a study using Xenopus oocytes. Biophys. J., 63, 235-246]. In this paper we extend our original model to include the effects of ...

journal_title：Cell calcium

authors： Jafri MS,Gillo B

更新日期：1994-07-01 00:00:00

abstract：:Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections are associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying novel targets/pathways required for MERS infectivity is therefore important for developing novel therapeutics. As an enveloped virus, translocation thr...

journal_title：Cell calcium

authors： Gunaratne GS,Yang Y,Li F,Walseth TF,Marchant JS

更新日期：2018-11-01 00:00:00

abstract：:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to ...

journal_title：Cell calcium

authors： Malviya AN

更新日期：1994-10-01 00:00:00

abstract：:Human CD3-, CD16+ natural killer cells (NKs) induced necrosis in the cell line K562 and the minor population of MOLT-4, while induced apoptosis in the majority of MOLT-4, in one-to-one cell interaction. Simultaneous Ca2+ imaging of NK and target cells revealed remarkable differences in changes of cytosolic Ca2+ concen...

journal_title：Cell calcium

authors： Honda Y,Miyazaki S

更新日期：1996-04-01 00:00:00

abstract：:Calcium release-activated calcium (CRAC) channels have been the target of drug discovery for many years. The identification of STIM and Orai proteins as key components of CRAC channels greatly facilitated this process because their co-expression in cell lines produced electrophysiological currents (ICRAC) much larger ...

journal_title：Cell calcium

authors： Stauderman KA

更新日期：2018-09-01 00:00:00

abstract：:This investigation concentrates on the change in Ca(2+) concentration ([Ca(2+)]) caused by ryanodine in U373 MG cells. This cell type from a human astrocytoma is a unique cellular model because it only expresses the type 3 ryanodine receptor (RyR3), which is generally the least abundant isoform. In the presence of phy...

journal_title：Cell calcium

authors： Galiano M,Gasparre G,Lippe C,Cassano G

更新日期：2004-11-01 00:00:00

abstract：:Calcium and redox signals are presently established as essential regulators of many cellular processes. Nevertheless, we are still far from fully understanding the physiological and pathological importance of these universal second messengers. It is becoming increasingly apparent that many cellular functions are not r...

journal_title：Cell calcium

authors： Gibhardt CS,Zimmermann KM,Zhang X,Belousov VV,Bogeski I

更新日期：2016-08-01 00:00:00

abstract：:Intracytoplasmic sperm injection (ICSI) into mammalian eggs induces repetitive rises in intracellular Ca2+ concentration ([Ca2+]i) which are the pivotal signal in fertilization. Spatiotemporal aspects of [Ca2+]i rises following ICSI into the periphery of mouse eggs were investigated with high-speed confocal microscopy...

journal_title：Cell calcium

authors： Sato MS,Yoshitomo M,Mohri T,Miyazaki S

更新日期：1999-07-01 00:00:00

abstract：:An inward current responsible for hormone regulated Ca2+ entry has been identified in cultured rat hepatocytes using whole cell patch clamp. Addition of 20 nM vasopressin or of 100 microM ATP induced the inward current, which could be observed more clearly after blocking an outward K+ current. This large outward K+ cu...

journal_title：Cell calcium

authors： Duszynski J,Elensky M,Cheung JY,Tillotson DL,LaNoue KF

更新日期：1995-07-01 00:00:00

abstract：:C3H/10T1/2 mouse embryo fibroblasts stimulated by a steady electric field (10 V/cm) for 30 min exhibited lamellar retraction on the sides facing the electrodes. Some cells elongated and preferentially oriented with their long axis perpendicular to the field direction. Depletion of external calcium or blockage of calci...

journal_title：Cell calcium

authors： Onuma EK,Hui SW

更新日期：1985-06-01 00:00:00

abstract：:Cellular calcium signaling events are transient. Hence they are observed in real time using fluorescence imaging or electrophysiological methods that require sophisticated instrumentation and specialized skills. For high throughput assays simple and inexpensive techniques are desirable. Many calcium channels that serv...

journal_title：Cell calcium

authors： Chandrika AR,Steephan M,Raveendran Nair R,Sudarsana Devi SP,Kumar M,Paul S,Madhavan M,Omkumar RV

更新日期：2018-09-01 00:00:00

abstract：:K+-dependent Na+-Ca2+ exchangers (NCKXs) belong to Ca2+/cation antiporter gene superfamily. NCKX proteins play an important role in Ca2+ homeostasis and are bi-directional plasma membrane Ca2+-transporters which utilize the inward Na+ and outward K+ gradients to move Ca2+ ions into and out of the cytosol (4Na+:1Ca2+ +...

journal_title：Cell calcium

authors： Jalloul AH,Liu G,Szerencsei RT,Schnetkamp PPM

更新日期：2018-09-01 00:00:00

abstract：:Cellular senescence is a stable cell proliferation arrest induced by a variety of stresses including telomere shortening, oncogene activation and oxidative stress. This process plays a crucial role in many physiopathological contexts, especially during aging when cellular senescence favors development of age-related d...

journal_title：Cell calcium

authors： Martin N,Bernard D

更新日期：2018-03-01 00:00:00

abstract：:In the presence of inositol (1,4,5)-trisphosphate (InsP3) repetitive waves of elevated cytosolic free Ca2+ (Ca waves) that travel through cellular cytoplasm are observed. Investigation of this phenomenon stimulated the view of cellular cytoplasm as 'an excitable medium composed of Ca release processes (InsP3R), couple...

journal_title：Cell calcium

authors： Bezprozvanny I

更新日期：1994-09-01 00:00:00

abstract：:Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...

journal_title：Cell calcium

authors： Harrington MA,Thompson SH

更新日期：1996-05-01 00:00:00

abstract：:It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...

journal_title：Cell calcium

authors： Kumar P,Brodie SG,Vaughan MK,Menendez-Pelaez A,Reiter RJ,Chambers JP

更新日期：1992-10-01 00:00:00

abstract：:Mathematical models are often used to elucidate mechanisms behind cytosolic Ca2+ oscillations. We have evaluated the use of mathematical modelling to analyse and quantify Ca2+ signal patterns, in single, adherent human neutrophils (PMN) after stimulation by the bacterial peptide N-formyl-methionyl-leucyl-phenylalanine...

journal_title：Cell calcium

authors： Røtnes JS,Røttingen JA

更新日期：1994-06-01 00:00:00