Abstract：
:The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling operate at 5-10% of maximal strength, but synergize to generate the maximal response. Although synergistic action of the Ca(2+) and cAMP signaling is the common mode of signaling and has been known for many years, we know very little of the molecular mechanism and mediators of the synergism. In this review, we discuss crosstalk between the Ca(2+) and cAMP signaling and the function of IRBIT (IP3 receptors binding protein release with IP3) as a third messenger that mediates the synergistic action of the Ca(2+) and cAMP signaling.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Ahuja M,Jha A,Maléth J,Park S,Muallem Sdoi
10.1016/j.ceca.2014.01.006subject
Has Abstractpub_date
2014-06-01 00:00:00pages
385-93issue
6eissn
0143-4160issn
1532-1991pii
S0143-4160(14)00022-0journal_volume
55pub_type
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