Abstract：
:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to heparin and is phosphorylated by nuclear PKC, enhancing the efficiency of IP3 in nuclear calcium release. There are two IP4 binding sites located to the nuclear envelope. The nuclear IP4R is sensitive to pH and pH 6.5 is found optimum for the ligand binding. The high affinity IP4R is associated with the outer nuclear membrane and mediates nuclear calcium uptake by IP4. Low affinity IP4R is identified with the inner nuclear membrane and is not involved in IP4 mediated calcium entry into the nucleus. The nature of IP4R associated with the outer nuclear membrane as compared with the one identified with the inner nuclear membrane remains to be elucidated.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Malviya ANdoi
10.1016/0143-4160(94)90094-9subject
Has Abstractpub_date
1994-10-01 00:00:00pages
301-13issue
4eissn
0143-4160issn
1532-1991pii
0143-4160(94)90094-9journal_volume
16pub_type
杂志文章相关文献
CELL CALCIUM文献大全abstract：:Calbindin D28K (formerly known as vitamin D-dependent calcium binding protein and referred to here as calbindin) is found in a wide variety of tissues, but only in certain cells within those tissues. Apart from its ability to bind calcium, nothing is known about its function in these cells. To investigate its role we ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90055-b
更新日期：1993-04-01 00:00:00
abstract：:In skeletal muscle excitation-contraction (EC) coupling the sarcolemmal L-type Ca(2+) channel or 1,4-dihydropyridine receptor (DHPR) transduces the membrane depolarization signal to the sarcoplasmic Ca(2+) release channel RyR1 via protein-protein interaction. While it is evident that the pore-forming and voltage-sensi...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2010.04.003
更新日期：2010-06-01 00:00:00
abstract：:Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PL...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2015.12.006
更新日期：2016-03-01 00:00:00
abstract：:Mathematical models are often used to elucidate mechanisms behind cytosolic Ca2+ oscillations. We have evaluated the use of mathematical modelling to analyse and quantify Ca2+ signal patterns, in single, adherent human neutrophils (PMN) after stimulation by the bacterial peptide N-formyl-methionyl-leucyl-phenylalanine...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90111-2
更新日期：1994-06-01 00:00:00
abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2015.03.008
更新日期：2015-10-01 00:00:00
abstract：:The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2011.12.007
更新日期：2012-03-01 00:00:00
abstract：:Dynamic nuclear Ca(2+) signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca(2+) regulatory mechanism mediated by inositol 1,4,5-trisphosphate receptors (IP(3)Rs) around the nucleus in developing cardiac myo...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2007.04.017
更新日期：2008-02-01 00:00:00
abstract：:The sternal epithelium of Porcellio scaber was used as a novel model to study the subcellular elemental distribution in control and Ca(2+)-transporting stages in situ. The anterior sternal epithelium (ASE) is specialized for transport of cuticular Ca to sternal CaCO(3) deposits during premolt, and from these deposits ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(02)00060-x
更新日期：2002-06-01 00:00:00
abstract：:Ca(2+) signals are universal among cells in regulating a spectrum of cellular responses. Phospholipase C-coupled receptors activate two components of Ca(2+) signals--rapid Ca(2+) release from ER stores, followed by slower Ca(2+) entry from outside the cell. The coupling process between ER and PM to mediate this "store...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2007.03.009
更新日期：2007-08-01 00:00:00
abstract：:In salivary acinar cells, muscarinic-induced fluid secretion is associated with a 1,4,5-IP3 induced increase in the cytosolic free Ca2+ concentration ([Ca2+]i), which in turn activates Ca(2+)-dependent K+ and Cl- channels that modulate the membrane potential. In the present study the influence of the membrane potentia...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90076-i
更新日期：1993-07-01 00:00:00
abstract：:There is controversy as to whether TRP channels participate in mediating store-operated current (I(SOC)) and store-operated Ca(2+) entry (SOCE). Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle traffick...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2011.08.006
更新日期：2011-12-01 00:00:00
abstract：:Studies were conducted to examine the possible involvement of Na+-Ca2+ exchanger in determining the magnitude of the endothelin-1 (ET-1)-receptor-mediated calcium signal in porcine lens epithelial cells. Cytoplasmic calcium concentration was measured in primary cultured cells loaded with Fura-2. ET-1 (100 nM) caused c...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(03)00085-x
更新日期：2003-09-01 00:00:00
abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2015.04.002
更新日期：2015-08-01 00:00:00
abstract：:Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch o...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2005.01.018
更新日期：2005-05-01 00:00:00
abstract：:The A23187 induced calcium uptake in ATP depleted cells was determined at pH 6.9 in the presence of trifluoperazine (TFP, 0.30 mM), compound 48/80 (0.89 mg/ml), 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8, 2.13 mM) and verapamil (1.81 mM). Apart from verapamil the drugs all increased the maximum rate of ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(84)90022-8
更新日期：1984-10-01 00:00:00
abstract：:The high capacity, low affinity Ca(2+) storage protein chromogranins are marker proteins of secretory granules that contain the most Ca(2+) in secretory cells. Along with the abundantly expressed chromogranins, the IP(3)R/Ca(2+) channels, the major intracellular Ca(2+) channels, are also expressed in secretory granule...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2011.12.008
更新日期：2012-03-01 00:00:00
abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2007.05.010
更新日期：2007-10-01 00:00:00
abstract：:Cell survival is promoted by the oncoprotein Bcl-2. Previous studies have established that one of the pro-survival actions of Bcl-2 is to reduce cellular fluxes of Ca2+ within cells. In particular, Bcl-2 has been demonstrated to inhibit the release of Ca2+ from the endoplasmic reticulum. However, the mechanism by whic...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2008.01.003
更新日期：2008-09-01 00:00:00
abstract：:Muscarinic acetylcholine (ACh) receptors activate the phospholipase C signal transduction pathway to promote the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and the consequent elevation of cytoplasmic calcium (Ca2+). The inositol phosphate and Ca(2+)-mobilization responses to ACh were analyzed in Xenopus ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90090-s
更新日期：1993-10-01 00:00:00
abstract：:Ca2+ is a fundamental intracellular signal that mediates a variety of disparate physiological functions often in the same cell. Ca2+ signals span a wide range of spatial and temporal scales, which endow them with the specificity required to induce defined cellular functions. Furthermore, Ca2+ signaling is highly plast...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2007.01.010
更新日期：2007-12-01 00:00:00
abstract：:A possible role of the nitric oxide (NO)/cGMP pathway in the regulation of Ca2+ entry into HT29/B6 human colonic epithelial cells was investigated using digital image processing of Fura-2 fluorescence and immunoblotting for nitric oxide synthase (NOS). We tested the hypothesis that Ca2+ store depletion causes increase...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(95)90071-3
更新日期：1995-04-01 00:00:00
abstract：:Intracytoplasmic sperm injection (ICSI) into mammalian eggs induces repetitive rises in intracellular Ca2+ concentration ([Ca2+]i) which are the pivotal signal in fertilization. Spatiotemporal aspects of [Ca2+]i rises following ICSI into the periphery of mouse eggs were investigated with high-speed confocal microscopy...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.1999.0053
更新日期：1999-07-01 00:00:00
abstract：:Cardiogenesis depends on a tightly regulated balance between proliferation and differentiation of cardiac progenitor cells (CPCs) and their cardiomyocyte descendants. While exposure of early mouse embryos to Ca(2+) channel antagonists has been associated with abnormal cardiac morphogenesis, less is known about the con...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2014.02.018
更新日期：2014-05-01 00:00:00
abstract：:Ca(2+) influx through voltage-gated Ca(2+) channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribb...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2012.06.004
更新日期：2012-09-01 00:00:00
abstract：:Ca2+ signals are known to mediate an array of cellular functions including secretion, contraction, and conductivity changes. In spite of the obvious role of Ca2+ in signalling, the control of Ca2+ within cells is known to be a complex phenomenon involving a number of distinct active and passive transport systems funct...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/0143-4160(89)90062-6
更新日期：1989-07-01 00:00:00
abstract：:Animals have evolved sophisticated physiological systems for sensing ambient temperature since changes in environmental temperatures affect various biological processes. Thermosensitive transient receptor potential (thermoTRP) channels serve as thermal sensors in diverse animal species. They are multimodal receptors t...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2014.12.001
更新日期：2015-03-01 00:00:00
abstract：:MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca2+) release. Systolic blood pressure (SBP) and vasoreactivity to VSMC con...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.03.006
更新日期：2019-06-01 00:00:00
abstract：:We have investigated the effects of glucose on cytosolic free calcium concentration in the insulin-secreting cell line HIT-T15. Addition of glucose (10 mM) caused a 20-75% increase in cytosolic [Ca2+] within 5 minutes compared to controls in the absence of glucose. A maximal increase in cytosolic [Ca2+] was obtained w...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(89)90015-8
更新日期：1989-11-01 00:00:00
abstract：:Indo-1 is a new fluorescent indicator of the intracellular free calcium concentration Cai++. Indo-1 may be used in a similar manner as its predecessor quin2 but offers the principal advantage that the Ca++ saturated form of the Ca++ chelator has a emission maximum different in wavelength from that of free indo-1 (400 ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(86)90003-5
更新日期：1986-08-01 00:00:00
abstract：:The sensitivity to Ca2+ of the Ca2+-dependent K+ channel can be increased by the artificial electron donor system ascorbate + phenazine-methosulphate in a variety of animal cells. In the human erythrocyte the shift from the 'low' to the 'high-affinity' state seems to depend on the reduction of a membrane component acc...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(83)90024-6
更新日期：1983-12-01 00:00:00
