当前位置： SCI文献检索 > CELL CALCIUM期刊下所有文献 > MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure.

MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure.

Abstract：

:MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca2+) release. Systolic blood pressure (SBP) and vasoreactivity to VSMC contractile agonists (phenylephrine (PE), thromboxane analogue (U46619), endothelin-1 (ET-1), angiotensin-II (Ang II) and norepinephrine (NE) were compared in aortas and mesenteric resistance arteries (MRA) from miR-204-/- mice and wildtype mice (WT). There was no difference in basal systolic blood pressure (SBP) between the two genotypes; however, hypertensive response to Ang II was significantly greater in miR-204-/- mice compared to WT mice. Aortas and MRA of miR-204-/- mice had heightened contractility to all VSMC agonists. In silico algorithms predicted the type 1 Inositol 1, 4, 5-trisphosphate receptor (IP3R1) as a target of miR-204. Aortas and MRA of miR-204-/- mice had higher expression of IP3R1 compared to WT mice. Difference in agonist-induced vasoconstriction between miR-204-/- and WT mice was abolished with pharmacologic inhibition of IP3R1. Furthermore, Ang II-induced aortic IP3R1 was greater in miR-204-/- mice compared to WT mice. In addition, difference in aortic vasoconstriction to VSMC agonists between miR-204-/- and WT mice persisted after Ang II infusion. Inhibition of miR-204 in VSMC in vitro increased IP3R1, and boosted SR Ca2+ release in response to PE, while overexpression of miR-204 downregulated IP3R1. Finally, a sequence-specific nucleotide blocker that targets the miR-204-IP3R1 interaction rescued miR-204-induced downregulation of IP3R1. We conclude that miR-204 controls VSMC contractility and blood pressure through IP3R1-dependent regulation of SR calcium release.

journal_name

Cell Calcium

journal_title

Cell calcium

authors

Gabani M,Liu J,Ait-Aissa K,Koval O,Kim YR,Castañeda D,Vikram A,Jacobs JS,Grumbach I,Trebak M,Irani K,Kassan M

doi

10.1016/j.ceca.2019.03.006

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

18-24

eissn

0143-4160

issn

1532-1991

pii

S0143-4160(19)30033-8

journal_volume

80

pub_type

杂志文章

相关文献

CELL CALCIUM文献大全
  • Inhibition of calmodulin-dependent and independent cardiac sarcoplasmic reticulum activities by R24571.

    abstract：:R24571 a derivative of the antimycotic miconazole, appears to be 5 to 8 times more potent than trifluoperazine in its ability to inhibit the calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum vesicles. The cAMP-dependent protein kinase mediated phosphorylation of cardiac sarcoplasmic reticulum was ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(83)90039-8

    authors： Louis CF,Turnquist J,Jarvis B

    更新日期：1983-04-01 00:00:00

  • Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels.

    abstract：:The non-selective second messenger-gated cation channel TRPC6 (transient receptor potential canonical 6) is activated by diacylglycerols (DAG) in a PKC-independent manner and plays important roles in a variety of physiological processes and diseases. In order to facilitate novel therapies, the development of potent in...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2018.12.009

    authors： Häfner S,Urban N,Schaefer M

    更新日期：2019-03-01 00:00:00

  • Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency.

    abstract：:NADH:ubiquinone oxidoreductase or complex I is a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain (ETC). Its dysfunction is associated with a range of progressive neurological disorders, often characterized by a ve...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2008.01.002

    authors： Willems PH,Valsecchi F,Distelmaier F,Verkaart S,Visch HJ,Smeitink JA,Koopman WJ

    更新日期：2008-07-01 00:00:00

  • A ryanodine-sensitive calcium store in ascidian eggs monitored by whole-cell patch-clamp recordings.

    abstract：:Using whole cell patch clamp recordings on unfertilized eggs of the ascidian Ciona intestinalis, we are able to detect ryanodine receptors within the oocytes. Our approach is based on measurements of the voltage-activated inward calcium currents. Two types of Ca2+ currents have been described on the oocyte membrane of...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(97)90033-6

    authors： Arnoult C,Albrieux M,Antoine AF,Grunwald D,Marty I,Villaz M

    更新日期：1997-02-01 00:00:00

  • Sodium and ouabain induce proliferation of rat thymic lymphocytes via calcium- and magnesium- dependent reactions.

    abstract：:When the concentrations of either calcium or of magnesium in the culture medium were increased from the normal 0.6 and 1.0 mM to 1.8 and 2.5 mM respectively mitotic activity of rat thymic lymphocytes increased. Very high (10(-4)M) ouabain concentrations abolished these mitogenic actions whilst lower (10(-7) and 10(-11...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(83)90044-1

    authors： Atkinson MJ,Cade C,Perris AD

    更新日期：1983-02-01 00:00:00

  • Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.

    abstract：:Here, we report the characterization of a human cDNA coding for the recently published amino acid sequence of a calcium-binding S100 protein, S100A12 (CGRP, calgranulin C, CAAF1, p6). The exon/intron structure of the S100A12 gene is similar to most other S100 genes. It is composed of three exons which are divided by t...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(96)90087-1

    authors： Wicki R,Marenholz I,Mischke D,Schäfer BW,Heizmann CW

    更新日期：1996-12-01 00:00:00

  • The effect of furosemide on calcium ion concentration in myocardial cells.

    abstract：:The effect of furosemide and ouabain on the intracellular concentration of Ca2+ was studies in myocardial cell cultures using Fura-2, a fluorescent agent, as an intracellular Ca2+ indicator. Introduction of 200 microM ouabain to the cultured cells increased the intracellular calcium concentration from an average of 23...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(95)90004-7

    authors： Rubin Y,Kessler-Icekson G,Navon G

    更新日期：1995-08-01 00:00:00

  • Activation of the nitric oxide/cGMP pathway is required for refilling intracellular Ca2+ stores in a sympathetic neuron cell line.

    abstract：:Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(96)90113-x

    authors： Harrington MA,Thompson SH

    更新日期：1996-05-01 00:00:00

  • Contribution of the cytoskeleton and the phospholipase C signaling pathway to fluid stream-induced membrane currents.

    abstract：:A fluid stream induced by a concentration clamp system evokes in Xenopus oocytes a deformation of the membrane which results in transient chloride currents of high amplitude (stream-evoked inward current, I(i,st)) during calcium-activated chloride current oscillations. The involvement of cytoskeleton elements and of c...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2003.09.005

    authors： Montag S,Krüger K,Madeja M,Speckmann EJ,Musshoff U

    更新日期：2004-04-01 00:00:00

  • Modulation of cardiac mechanosensitive ion channels involves superoxide, nitric oxide and peroxynitrite.

    abstract：:In murine ventricular myocytes, activation of mechanosensitive ion channels (MSCs) includes activation of non-selective cation currents and deactivation of inwardly rectifying potassium currents. Using pharmacological inhibitors and knockout models, we analyzed signaling steps that are critical to transduce the mechan...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2008.06.002

    authors： Dyachenko V,Rueckschloss U,Isenberg G

    更新日期：2009-01-01 00:00:00

  • Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria.

    abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2007.05.010

    authors： Chalmers S,Olson ML,MacMillan D,Rainbow RD,McCarron JG

    更新日期：2007-10-01 00:00:00

  • Inositol 1,4,5 trisphosphate receptor 1 is a key player of human myoblast differentiation.

    abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2014.10.014

    authors： Antigny F,Konig S,Bernheim L,Frieden M

    更新日期：2014-12-01 00:00:00

  • Parvalbumin as a metal-dependent antioxidant.

    abstract：:Parvalbumin (PA) is a Ca(2+)-binding protein of vertebrates massively expressed in tissues with high oxygen uptake and respectively elevated level of reactive oxygen species (ROS). To characterize antioxidant properties of PA, antioxidant capacity (AOC) of intact rat α-PA has been explored. ORAC, TEAC and hydrogen per...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2014.03.001

    authors： Permyakov SE,Kazakov AS,Avkhacheva NV,Permyakov EA

    更新日期：2014-05-01 00:00:00

  • Inhibition of store-dependent capacitative Ca2+ influx by unsaturated fatty acids.

    abstract：:The effects of the unsaturated fatty acids, arachidonic and oleic acid, on the influx of Ca2+ activated by depletion of intracellular stores with thapsigargin were investigated in various cell types. By using a Ca2+ free/Ca2+ reintroduction protocol, we observed that arachidonic acid (2 to 5 microM) inhibited thapsiga...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(97)90031-2

    authors： Gamberucci A,Fulceri R,Benedetti A

    更新日期：1997-05-01 00:00:00

  • Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines.

    abstract：:The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. In...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(95)90111-6

    authors： Wolkoff LI,Perrone RD,Grubman SA,Lee DW,Soltoff SP,Rogers LC,Beinborn M,Fang SL,Cheng SH,Jefferson DM

    更新日期：1995-05-01 00:00:00

  • Molecular pathways underlying the modulation of T-type calcium channels by neurotransmitters and hormones.

    abstract：:Low-voltage-activated T-type calcium channels are expressed in various tissues, especially in the brain, where they promote neuronal firing and are involved in slow wave sleep and absence epilepsy. While the transduction pathways by which hormones and neurotransmitters modulate high-voltage-activated calcium channels ...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2006.04.015

    authors： Chemin J,Traboulsie A,Lory P

    更新日期：2006-08-01 00:00:00

  • Intact pancreatic islets and dispersed beta-cells both generate intracellular calcium oscillations but differ in their responsiveness to glucose.

    abstract：:Pancreatic islets produce pulses of insulin and other hormones that maintain normal glucose homeostasis. These micro-organs possess exquisite glucose-sensing capabilities, allowing for precise changes in pulsatile insulin secretion in response to small changes in glucose. When communication among these cells is disrup...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2019.102081

    authors： Scarl RT,Corbin KL,Vann NW,Smith HM,Satin LS,Sherman A,Nunemaker CS

    更新日期：2019-11-01 00:00:00

  • TRPC1: the link between functionally distinct store-operated calcium channels.

    abstract：:Although store-operated calcium entry (SOCE) was identified more that two decades ago, understanding the molecular mechanisms that regulate and mediate this process continue to pose a major challenge to investigators in this field. Thus, there has been major focus on determining which of the models proposed for this m...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2007.01.013

    authors： Ambudkar IS,Ong HL,Liu X,Bandyopadhyay BC,Cheng KT

    更新日期：2007-08-01 00:00:00

  • Characterization of the maitotoxin-induced calcium influx pathway from human skin fibroblasts.

    abstract：:Maitotoxin (MTX), a water-soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus increased intracellular calcium in a concentration-dependent manner in fibroblasts obtained from human skin. The effect of this toxin was both saturable and of high affinity, showing an apparent half activation co...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(97)90087-7

    authors： Gutierrez D,Díaz de León L,Vaca L

    更新日期：1997-07-01 00:00:00

  • Calcium microdomains and gene expression in neurons and skeletal muscle cells.

    abstract：:Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting synaptic plasticity--a neuronal response presumably correlated with cognitive brain functions t...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2006.08.021

    authors： Carrasco MA,Hidalgo C

    更新日期：2006-11-01 00:00:00

  • Effect of trifluoperazine, compound 48/80, TMB-8 and verapamil on ionophore A23187 mediated calcium uptake in ATP depleted human red cells.

    abstract：:The A23187 induced calcium uptake in ATP depleted cells was determined at pH 6.9 in the presence of trifluoperazine (TFP, 0.30 mM), compound 48/80 (0.89 mg/ml), 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8, 2.13 mM) and verapamil (1.81 mM). Apart from verapamil the drugs all increased the maximum rate of ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(84)90022-8

    authors： Foder B,Skibsted U,Scharff O

    更新日期：1984-10-01 00:00:00

  • Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling.

    abstract：:Vesl/Homer proteins physically link proteins that mediate cellular signaling [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851] and thereby influence cellular function [Nat. Neurosci. 4 (2001) 499; Nature 411 (2001) 962]. A previous study reported that Vesl-1L/Homer-1c ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(03)00082-4

    authors： Hwang SY,Wei J,Westhoff JH,Duncan RS,Ozawa F,Volpe P,Inokuchi K,Koulen P

    更新日期：2003-08-01 00:00:00

  • Contribution of capacitative and non-capacitative Ca2+-entry to M3-receptor-mediated contraction of porcine coronary smooth muscle.

    abstract：:We studied the contribution of store-operated or capacitative Ca2+-entry (SOCE or CCE, respectively) through store-operated Ca2+ channels (SOCCs) and the contribution of Ca2+-entry through receptor-operated, non-selective cation channels (ROCCs or NSCCs, respectively), on the M3-receptor-mediated (270 nM Ach) contract...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2005.06.035

    authors： Weirich J,Dumont L,Fleckenstein-Grün G

    更新日期：2005-11-01 00:00:00

  • Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium/reactive oxygen and nitrogen species cross-talk signaling.

    abstract：:In previous works, we have shown that L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors (NMDAr), neuronal nitric oxide synthase (nNOS) and cytochrome b5 reductase (Cb5R) co-localize within the same lipid rafts-associated nanodomains in mature cerebellar granule neurons (CGN). In this work, we sh...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2014.06.002

    authors： Marques-da-Silva D,Gutierrez-Merino C

    更新日期：2014-08-01 00:00:00

  • Calcium microdomains in regulated exocytosis.

    abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/j.ceca.2006.08.007

    authors： Oheim M,Kirchhoff F,Stühmer W

    更新日期：2006-11-01 00:00:00

  • Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.

    abstract：:Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane...

    journal_title：Cell calcium

    pub_type： 杂志文章,评审

    doi：10.1016/0143-4160(86)90042-4

    authors： Morgan BP,Luzio JP,Campbell AK

    更新日期：1986-12-01 00:00:00

  • Membrane potential regulates Ca2+ uptake and inositol phosphate generation in rat sublingual mucous acini.

    abstract：:In salivary acinar cells, muscarinic-induced fluid secretion is associated with a 1,4,5-IP3 induced increase in the cytosolic free Ca2+ concentration ([Ca2+]i), which in turn activates Ca(2+)-dependent K+ and Cl- channels that modulate the membrane potential. In the present study the influence of the membrane potentia...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(93)90076-i

    authors： Zhang GH,Melvin JE

    更新日期：1993-07-01 00:00:00

  • Effects of the thyroid status on the sarcoplasmic reticulum in slow skeletal muscle of the rat.

    abstract：:The effects of the thyroid status on the Ca++-transporting capabilities of rat slow skeletal muscle (m.soleus) were studied. The oxalate supported Ca++-uptake activity and Ca++-loading capacity of muscle homogenates from hyperthyroid rats showed an approximate 4.2 and 2.5 fold increase, respectively, as compared to va...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/0143-4160(86)90018-7

    authors： Simonides WS,van Hardeveld C

    更新日期：1986-06-01 00:00:00

  • Novel fluo-4 analogs for fluorescent calcium measurements.

    abstract：:We report new fluorescent calcium indicators based on fluo-4. Attachment of a carboxamide or methylenecarboxamide moiety to the BAPTA chelator portion of fluo-4 allowed for the attachment of dextrans, protein-reactive moieties, and biotin. In particular, a high affinity fluo-4 dextran conjugate was prepared and shown ...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/j.ceca.2004.05.002

    authors： Martin VV,Beierlein M,Morgan JL,Rothe A,Gee KR

    更新日期：2004-12-01 00:00:00

  • Distinct Ca2+ response patterns in human natural killer cells during induction of necrosis or apoptosis of target cells.

    abstract：:Human CD3-, CD16+ natural killer cells (NKs) induced necrosis in the cell line K562 and the minor population of MOLT-4, while induced apoptosis in the majority of MOLT-4, in one-to-one cell interaction. Simultaneous Ca2+ imaging of NK and target cells revealed remarkable differences in changes of cytosolic Ca2+ concen...

    journal_title：Cell calcium

    pub_type： 杂志文章

    doi：10.1016/s0143-4160(96)90070-6

    authors： Honda Y,Miyazaki S

    更新日期：1996-04-01 00:00:00