NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system.

abstract：:The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2+) channel to regulate IP(3)-mediated Ca(2+) release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and al...

journal_title：Cell calcium

authors： Distelhorst CW,Bootman MD

更新日期：2011-09-01 00:00:00

abstract：:In many animals, a rise in intracellular calcium levels is the trigger for egg activation, the process by which an arrested mature oocyte transitions to prepare for embryogenesis. In nearly all animals studied to date, this calcium rise, and thus egg activation, is triggered by the fertilizing sperm. However in the in...

journal_title：Cell calcium

authors： Sartain CV,Wolfner MF

更新日期：2013-01-01 00:00:00

abstract：:Low-voltage-activated T-type calcium channels are expressed in various tissues, especially in the brain, where they promote neuronal firing and are involved in slow wave sleep and absence epilepsy. While the transduction pathways by which hormones and neurotransmitters modulate high-voltage-activated calcium channels ...

journal_title：Cell calcium

authors： Chemin J,Traboulsie A,Lory P

更新日期：2006-08-01 00:00:00

abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...

journal_title：Cell calcium

authors： Oheim M,Kirchhoff F,Stühmer W

更新日期：2006-11-01 00:00:00

abstract：:TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as a potent entry point of working desperate diseases out in a new way with newfangled ideas and safer technological means....

journal_title：Cell calcium

authors： Chen Y,Zhang X,Yang T,Bi R,Huang Z,Ding H,Li J,Zhang J

更新日期：2019-05-01 00:00:00

abstract：:Smooth muscle contraction is regulated by changes in cytosolic Ca(2+) concentration ([Ca(2+)](i)). In response to stimulation, Ca(2+) increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca(2+) waves. To investigate the mechanisms underlying Ca(2+) wave propagation betw...

journal_title：Cell calcium

authors： Halidi N,Boittin FX,Bény JL,Meister JJ

更新日期：2011-11-01 00:00:00

abstract：:Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of neuronal circuit function, structure and molecular composition in the brain of awake behaving adult mice. Thus, mice have become a crit...

journal_title：Cell calcium

authors： Radulescu CI,Cerar V,Haslehurst P,Kopanitsa M,Barnes SJ

更新日期：2021-01-23 00:00:00

abstract：:To characterize the effect that a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY294002, has on cytosolic calcium concentrations ([Ca2+]i), bovine airway smooth muscle cells (BASMC) and cultured human bronchial smooth muscle cells (HBSMC) were loaded with fura 2-AM, imaged as single cells and [Ca2+]i measured...

journal_title：Cell calcium

authors： Ethier MF,Madison JM

更新日期：2002-07-01 00:00:00

abstract：:Fura-2 and BAPTA were previously shown to be competitive antagonists of inositol trisphosphate (InsP3) receptors, but for practical reasons the analyses were performed at pH 8.3. We recently developed a scintillation proximity assay (SPA) for pure cerebellar InsP3 receptors which allows low affinity interactions to be...

journal_title：Cell calcium

authors： Morris SA,Correa V,Cardy TJ,O'Beirne G,Taylor CW

更新日期：1999-02-01 00:00:00

abstract：:A characteristic feature of developing neural networks is spontaneous periodic activity. In the developing retina, retinal ganglion cells fire bursts of action potentials that drive large increases in intracellular calcium concentration with a periodicity of minutes. These periodic bursts of action potentials propagat...

journal_title：Cell calcium

authors： Firth SI,Wang CT,Feller MB

更新日期：2005-05-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting synaptic plasticity--a neuronal response presumably correlated with cognitive brain functions t...

journal_title：Cell calcium

authors： Carrasco MA,Hidalgo C

更新日期：2006-11-01 00:00:00

abstract：:We have previously demonstrated a role for the reorganization of the actin cytoskeleton in store-operated calcium entry (SOCE) in human platelets and interpreted this as evidence for a de novo conformational coupling step in SOCE activation involving the type II IP(3) receptor and the platelet hTRPC1-containing store-...

journal_title：Cell calcium

authors： Harper AG,Sage SO

更新日期：2007-12-01 00:00:00

abstract：:Cellular senescence is a stable cell proliferation arrest induced by a variety of stresses including telomere shortening, oncogene activation and oxidative stress. This process plays a crucial role in many physiopathological contexts, especially during aging when cellular senescence favors development of age-related d...

journal_title：Cell calcium

authors： Martin N,Bernard D

更新日期：2018-03-01 00:00:00

abstract：:In previous works, we have shown that L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors (NMDAr), neuronal nitric oxide synthase (nNOS) and cytochrome b5 reductase (Cb5R) co-localize within the same lipid rafts-associated nanodomains in mature cerebellar granule neurons (CGN). In this work, we sh...

journal_title：Cell calcium

authors： Marques-da-Silva D,Gutierrez-Merino C

更新日期：2014-08-01 00:00:00

abstract：:The spatiotemporal dynamics of elementary Ca(2+) release events, such as "blips" and "puffs" shapes the hierarchal Ca(2+) signaling in many cell types. Despite being the building blocks of Ca(2+) patterning, the mechanism responsible for the observed properties of puffs, especially their termination is incompletely un...

journal_title：Cell calcium

authors： Ullah G,Parker I,Mak DO,Pearson JE

更新日期：2012-08-01 00:00:00

abstract：:Calcium and calcium-dependent systems have been long implicated in the induction of epilepsy. We have previously observed that intracellular calcium ([Ca2+]i) levels remain elevated in cells undergoing epileptogenesis in the hippocampal neuronal culture (HNC) model. In this study, we employed the hippocampal neuronal ...

journal_title：Cell calcium

authors： Pal S,Limbrick DD Jr,Rafiq A,DeLorenzo RJ

更新日期：2000-09-01 00:00:00

abstract：:In salivary acinar cells, muscarinic-induced fluid secretion is associated with a 1,4,5-IP3 induced increase in the cytosolic free Ca2+ concentration ([Ca2+]i), which in turn activates Ca(2+)-dependent K+ and Cl- channels that modulate the membrane potential. In the present study the influence of the membrane potentia...

journal_title：Cell calcium

authors： Zhang GH,Melvin JE

更新日期：1993-07-01 00:00:00

abstract：:Agonist-induced calcium (Ca) mobilization is accompanied by Ca efflux, presumably reflecting the rise in Ca concentration at the cytosolic surface of the cell membrane. We studied the relationship between Ca efflux and intracellular Ca mobilization in Xenopus oocytes. Elevation of cytosolic Ca by a direct injection of...

journal_title：Cell calcium

authors： Shapira H,Lupu-Meiri M,Lipinsky D,Oron Y

更新日期：1996-03-01 00:00:00

abstract：:Muscarinic acetylcholine (ACh) receptors activate the phospholipase C signal transduction pathway to promote the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and the consequent elevation of cytoplasmic calcium (Ca2+). The inositol phosphate and Ca(2+)-mobilization responses to ACh were analyzed in Xenopus ...

journal_title：Cell calcium

authors： Ji H,Sandberg K,Bonner TI,Catt KJ

更新日期：1993-10-01 00:00:00

abstract：:R24571 a derivative of the antimycotic miconazole, appears to be 5 to 8 times more potent than trifluoperazine in its ability to inhibit the calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum vesicles. The cAMP-dependent protein kinase mediated phosphorylation of cardiac sarcoplasmic reticulum was ...

journal_title：Cell calcium

authors： Louis CF,Turnquist J,Jarvis B

更新日期：1983-04-01 00:00:00

abstract：:When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...

journal_title：Cell calcium

authors： Kaneko S,Doi E,Watanabe H,Nomura Y

更新日期：1990-04-01 00:00:00

abstract：:In non-excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel which plays a major role in Ca2+ signalling. Three isoforms of IP3R have been identified (IP3R-1, IP3R-2 and IP3R-3) and most cell types express different proportions of each isoform. The differences between the p...

journal_title：Cell calcium

authors： Caron AZ,Chaloux B,Arguin G,Guillemette G

更新日期：2007-09-01 00:00:00

abstract：:The mechanism by which the depletion of intracellular Ca2+ stores stimulates Ca2+ influx is poorly understood. However, the coupling of depletion to influx is broken during mitosis [Preston, S.F. et. al., (1991) Cell Regul., 2, 915-925]. Thus, in interphase HeLa cells, activation of the histamine H1 receptor, or incub...

journal_title：Cell calcium

authors： Berlin RD,Preston SF

更新日期：1993-05-01 00:00:00

abstract：:Secretory granules of pancreatic β-cells contain high concentrations of Ca2+ ions that are co-released with insulin in the extracellular milieu upon activation of exocytosis. As a consequence, an increase in the extracellular Ca2+ concentration ([Ca2+]ext) in the microenvironment immediately surrounding β-cells should...

journal_title：Cell calcium

authors： Gerbino A,Maiellaro I,Carmone C,Caroppo R,Debellis L,Barile M,Busco G,Colella M

更新日期：2012-05-01 00:00:00

abstract：:Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the polarized nature of the secretory epithelial cells. In pancreatic acinar cells, for example, Ca2+ reloading of empty intracellular stores can occur solely via Ca2+ entry through the basal part of the plasma membrane. On...

journal_title：Cell calcium

authors： Petersen OH

更新日期：2003-05-01 00:00:00

abstract：:A possible role of the nitric oxide (NO)/cGMP pathway in the regulation of Ca2+ entry into HT29/B6 human colonic epithelial cells was investigated using digital image processing of Fura-2 fluorescence and immunoblotting for nitric oxide synthase (NOS). We tested the hypothesis that Ca2+ store depletion causes increase...

journal_title：Cell calcium

authors： Bischof G,Brenman J,Bredt DS,Machen TE

更新日期：1995-04-01 00:00:00

abstract：:Nanosecond-duration electric stimuli are distinguished by the ability to permeabilize intracellular membranes and recruit Ca2+ from intracellular stores. We quantified this effect in non-excitable cells (CHO) using ratiometric Ca2+ imaging with Fura-2. In a Ca(2+)-free medium, 10-, 60-, and 300-ns stimuli evoked Ca2+ ...

journal_title：Cell calcium

authors： Semenov I,Xiao S,Pakhomova ON,Pakhomov AG

更新日期：2013-09-01 00:00:00

abstract：:A new method for the determination of tissue concentrations of Fura-2 and Fura-2/AM was developed based upon acetonitrile extraction followed by RP-HPLC separation (using tetrahexylammonium as counter-ion), post-column alkaline hydrolysis of Fura-2/AM, and fluorimetric detection. The detection limit was 1.2 nM and 1 n...

journal_title：Cell calcium

authors： Tran NN,Leroy P,Bellucci L,Robert A,Nicolas A,Atkinson J,Capdeville-Atkinson C

更新日期：1995-11-01 00:00:00

abstract：:Adipokinetic hormone (AKH)-induced mobilization of insect fat body glycogen occurs through activation of glycogen phosphorylase. In the migratory locust, signal transduction of AKH-I, -II and -III has been shown to involve the formation of cAMP. In the present study, we show that both the elevation of fat body cAMP le...

journal_title：Cell calcium

authors： Vroemen SF,Van Marrewijk WJ,Schepers CC,Van der Horst DJ

更新日期：1995-06-01 00:00:00