Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium/reactive oxygen and nitrogen species cross-talk signaling.

abstract：:Atypical absence epilepsy (AAE) is an intractable disorder characterized by slow spike-and-wave discharges in electroencephalograms (EEGs) and accompanied by severe cognitive dysfunction and neurodevelopmental or neurological deficits in humans. Administration of the cholesterol biosynthesis inhibitor AY-9944 (AY) dur...

journal_title：Cell calcium

authors： Jung S,Jeong Y,Jeon D

更新日期：2015-05-01 00:00:00

abstract：:Fura-2 and BAPTA were previously shown to be competitive antagonists of inositol trisphosphate (InsP3) receptors, but for practical reasons the analyses were performed at pH 8.3. We recently developed a scintillation proximity assay (SPA) for pure cerebellar InsP3 receptors which allows low affinity interactions to be...

journal_title：Cell calcium

authors： Morris SA,Correa V,Cardy TJ,O'Beirne G,Taylor CW

更新日期：1999-02-01 00:00:00

abstract：:Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections are associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying novel targets/pathways required for MERS infectivity is therefore important for developing novel therapeutics. As an enveloped virus, translocation thr...

journal_title：Cell calcium

authors： Gunaratne GS,Yang Y,Li F,Walseth TF,Marchant JS

更新日期：2018-11-01 00:00:00

abstract：:There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol...

journal_title：Cell calcium

authors： Taggart MJ,Wray S

更新日期：1997-11-01 00:00:00

abstract：:When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...

journal_title：Cell calcium

authors： Kaneko S,Doi E,Watanabe H,Nomura Y

更新日期：1990-04-01 00:00:00

abstract：:We have previously demonstrated that bradykinin potentiates prostaglandin E(2)release in human gingival fibroblasts pretreated with interleukin-1 beta (priming). In this study, we demonstrate a potentiating effect of bradykinin on cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts. Interleuk...

journal_title：Cell calcium

authors： Nakao S,Ogata Y,Modéer T,Segawa M,Furuyama S,Sugiya H

更新日期：2001-06-01 00:00:00

abstract：:We report new fluorescent calcium indicators based on fluo-4. Attachment of a carboxamide or methylenecarboxamide moiety to the BAPTA chelator portion of fluo-4 allowed for the attachment of dextrans, protein-reactive moieties, and biotin. In particular, a high affinity fluo-4 dextran conjugate was prepared and shown ...

journal_title：Cell calcium

authors： Martin VV,Beierlein M,Morgan JL,Rothe A,Gee KR

更新日期：2004-12-01 00:00:00

abstract：:We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that a...

journal_title：Cell calcium

authors： Fraiman D,Dawson SP

更新日期：2004-05-01 00:00:00

abstract：:Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting synaptic plasticity--a neuronal response presumably correlated with cognitive brain functions t...

journal_title：Cell calcium

authors： Carrasco MA,Hidalgo C

更新日期：2006-11-01 00:00:00

abstract：:The sternal epithelium of Porcellio scaber was used as a novel model to study the subcellular elemental distribution in control and Ca(2+)-transporting stages in situ. The anterior sternal epithelium (ASE) is specialized for transport of cuticular Ca to sternal CaCO(3) deposits during premolt, and from these deposits ...

journal_title：Cell calcium

authors： Ziegler A

更新日期：2002-06-01 00:00:00

abstract：:Calbindin D28K (formerly known as vitamin D-dependent calcium binding protein and referred to here as calbindin) is found in a wide variety of tissues, but only in certain cells within those tissues. Apart from its ability to bind calcium, nothing is known about its function in these cells. To investigate its role we ...

journal_title：Cell calcium

authors： Muir EM,Lawson DE,Sepúlveda FV,O'Brien JA,Harding M

更新日期：1993-04-01 00:00:00

abstract：:In murine ventricular myocytes, activation of mechanosensitive ion channels (MSCs) includes activation of non-selective cation currents and deactivation of inwardly rectifying potassium currents. Using pharmacological inhibitors and knockout models, we analyzed signaling steps that are critical to transduce the mechan...

journal_title：Cell calcium

authors： Dyachenko V,Rueckschloss U,Isenberg G

更新日期：2009-01-01 00:00:00

abstract：:Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually ...

journal_title：Cell calcium

authors： Baines CP,Gutiérrez-Aguilar M

更新日期：2018-07-01 00:00:00

abstract：:The properties of the Ca2+, Mg2+-ATPase of erythrocyte membranes from patients with cystic fibrosis (CF) were extensively compared to that of healthy controls. Following removal of an endogenous membrane inhibitor of the ATPase, activation of the enzyme by Ca2+, calmodulin, limited tryptic digestion or oleic acid, as ...

journal_title：Cell calcium

authors： Waller RL,Johnson LR,Brattin WJ,Dearborn DG

更新日期：1985-06-01 00:00:00

abstract：:An important challenge in the study of Ca2+ signalling is to understand the dynamics of intracellular Ca2+ levels during and after physiological stimulation. While extensive information is available regarding the structural and biophysical properties of Ca2+ channels, pumps and exchangers that control cellular Ca2+ mo...

journal_title：Cell calcium

authors： Friel DD

更新日期：2000-11-01 00:00:00

abstract：:A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition, changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal content) or the magnitude of individual release events (quantal size) in both the short- and long-term. It is generally agreed that ...

journal_title：Cell calcium

authors： Barclay JW,Morgan A,Burgoyne RD

更新日期：2005-09-01 00:00:00

abstract：:Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane...

journal_title：Cell calcium

authors： Morgan BP,Luzio JP,Campbell AK

更新日期：1986-12-01 00:00:00

abstract：:An influx of Ca2+ into red blood cells of the bivalve mollusc Noetia ponderosa occurs immediately following a hypo-osmotic stress. The volume recovery response to the stress is dependent upon [Ca2+]o and is inhibited by phenothiazines. The action of these drugs is on the amino acid regulation portion of the recovery r...

journal_title：Cell calcium

authors： Pierce SK,Politis AD,Cronkite DH,Rowland LM,Smith LH Jr

更新日期：1989-04-01 00:00:00

abstract：:Using the low-affinity fluorescent Ca(2+) indicators, Mag-Fura-2 and Mag-Fura Red, we studied light- and InsP(3)-induced Ca(2+) release in permeabilized microvillar photoreceptors of the medicinal leech, Hirudo medicinalis. Two major components of the phosphoinositide signaling pathway, phospholipase-C and the InsP(3)...

journal_title：Cell calcium

authors： Ukhanov K,Mills SJ,Potter BV,Walz B

更新日期：2001-05-01 00:00:00

abstract：:Parvalbumin (PA) is a Ca(2+)-binding protein of vertebrates massively expressed in tissues with high oxygen uptake and respectively elevated level of reactive oxygen species (ROS). To characterize antioxidant properties of PA, antioxidant capacity (AOC) of intact rat α-PA has been explored. ORAC, TEAC and hydrogen per...

journal_title：Cell calcium

authors： Permyakov SE,Kazakov AS,Avkhacheva NV,Permyakov EA

更新日期：2014-05-01 00:00:00

abstract：:TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP) superfamily. This calcium-selective channel is highly expressed in the duodenum and the placenta, being responsible for calcium absorption in the body and fetus. Previous observations have suggested that TRPV6 is not only permeable...

journal_title：Cell calcium

authors： Kovacs G,Danko T,Bergeron MJ,Balazs B,Suzuki Y,Zsembery A,Hediger MA

更新日期：2011-01-01 00:00:00

abstract：:Factors contributing to "local control" of Ca2+ release in cardiac myocytes are incompletely understood. We induced local release of Ca2+ by regional exposure of mouse atrial and ventricular myocytes to 10mM caffeine for 500 ms using a rapid solution switcher. Propagation of Ca2+ release was imaged by means of a Nipko...

journal_title：Cell calcium

authors： Seguchi H,Ritter M,Shizukuishi M,Ishida H,Chokoh G,Nakazawa H,Spitzer KW,Barry WH

更新日期：2005-07-01 00:00:00

abstract：:The mechanism by which the depletion of intracellular Ca2+ stores stimulates Ca2+ influx is poorly understood. However, the coupling of depletion to influx is broken during mitosis [Preston, S.F. et. al., (1991) Cell Regul., 2, 915-925]. Thus, in interphase HeLa cells, activation of the histamine H1 receptor, or incub...

journal_title：Cell calcium

authors： Berlin RD,Preston SF

更新日期：1993-05-01 00:00:00

abstract：:Using the fluorescent Ca2+ probe Quin-2 it has been reported that cholera toxin (CT) and its B subunit (B-CT) increase cytosolic free Ca2+ concentration ([Ca2+]i) in entherocytes, thymocytes and fibroblasts. In this work we show, however, that the fluorescence increases of Quin-2-loaded cells (rat thymocytes, mouse sp...

journal_title：Cell calcium

authors： Astashkin EI,Surin AM,Mikhna MG,Nikolaeva IS,Lazarev AV,Gukovskaya AS

更新日期：1990-06-01 00:00:00

abstract：:MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MA...

journal_title：Cell calcium

authors： Karandikar M,Cobb MH

更新日期：1999-11-01 00:00:00

abstract：:The annexins are a family of calcium-binding proteins. Data from protein and cDNA sequencing have shown that at least five distinct but closely related mammalian annexins exist each of which possesses four or eight homologous internal repeats which may be calcium-and phospholipid-binding domains. The proteins are pres...

journal_title：Cell calcium

authors： Burgoyne RD,Geisow MJ

更新日期：1989-01-01 00:00:00

abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...

journal_title：Cell calcium

authors： Chalmers S,Olson ML,MacMillan D,Rainbow RD,McCarron JG

更新日期：2007-10-01 00:00:00

abstract：:The non-selective second messenger-gated cation channel TRPC6 (transient receptor potential canonical 6) is activated by diacylglycerols (DAG) in a PKC-independent manner and plays important roles in a variety of physiological processes and diseases. In order to facilitate novel therapies, the development of potent in...

journal_title：Cell calcium

authors： Häfner S,Urban N,Schaefer M

更新日期：2019-03-01 00:00:00

abstract：:In skeletal muscle excitation-contraction (EC) coupling the sarcolemmal L-type Ca(2+) channel or 1,4-dihydropyridine receptor (DHPR) transduces the membrane depolarization signal to the sarcoplasmic Ca(2+) release channel RyR1 via protein-protein interaction. While it is evident that the pore-forming and voltage-sensi...

journal_title：Cell calcium

authors： Dayal A,Schredelseker J,Franzini-Armstrong C,Grabner M

更新日期：2010-06-01 00:00:00

abstract：:Ca(2+) signals are universal among cells in regulating a spectrum of cellular responses. Phospholipase C-coupled receptors activate two components of Ca(2+) signals--rapid Ca(2+) release from ER stores, followed by slower Ca(2+) entry from outside the cell. The coupling process between ER and PM to mediate this "store...

journal_title：Cell calcium

authors： Hewavitharana T,Deng X,Soboloff J,Gill DL

更新日期：2007-08-01 00:00:00