Abstract：
:We have constructed a stochastic model of the inositol 1,4,5-trisphosphate receptor-Ca2+ channel that is based on quantitative measurements of the channel's properties. It displays the observed dependence of the open probability of the channel with cytosolic [Ca2+] and [IP3] and gives values for the dwell times that agree with the observations. The model includes an explicit dependence of channel gating with luminal calcium. This not only explains several observations reported in the literature, but also provides a possible explanation of why the open probabilities and shapes of the bell-shaped curves reported in [Nature 351 (1991) 751] and in [Proc. Natl. Acad. Sci. U.S.A. 269 (1998) 7238] are so different.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Fraiman D,Dawson SPdoi
10.1016/j.ceca.2003.10.004keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
403-13issue
5eissn
0143-4160issn
1532-1991pii
S0143416003002124journal_volume
35pub_type
杂志文章相关文献
CELL CALCIUM文献大全abstract：:Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2013.02.001
更新日期：2013-05-01 00:00:00
abstract：:Cellular Ca2+ signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca2+ channels cause large fluctuations in local Ca2+ concentration (Ca2+ 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca2+-sensitive probes from attoliter volumes it has become poss...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.102152
更新日期：2020-03-01 00:00:00
abstract：:There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(97)90018-x
更新日期：1997-11-01 00:00:00
abstract：:Intracellular Ca(2+)-transport ATPases exert a pivotal role in the endoplasmic reticulum and in the compartments of the cellular secretory pathway by maintaining a sufficiently high lumenal Ca(2+) (and Mn(2+)) concentration in these compartments required for an impressive number of vastly different cell functions. At ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/s0143416002001847
更新日期：2002-11-01 00:00:00
abstract：:Fluorescence imaging of calcium ions (Ca(2+)) has become an essential technique for investigation of signaling pathways involving Ca(2+) as a second messenger. But, Ca(2+) signaling is involved in many biological phenomena, and therefore simultaneous visualization of Ca(2+) and other biomolecules (multicolor imaging) ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2016.06.002
更新日期：2016-10-01 00:00:00
abstract：:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.102156
更新日期：2020-03-01 00:00:00
abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2006.04.023
更新日期：2006-08-01 00:00:00
abstract：:C3H/10T1/2 mouse embryo fibroblasts stimulated by a steady electric field (10 V/cm) for 30 min exhibited lamellar retraction on the sides facing the electrodes. Some cells elongated and preferentially oriented with their long axis perpendicular to the field direction. Depletion of external calcium or blockage of calci...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(85)90012-0
更新日期：1985-06-01 00:00:00
abstract：:TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as a potent entry point of working desperate diseases out in a new way with newfangled ideas and safer technological means....
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2019.02.011
更新日期：2019-05-01 00:00:00
abstract：:Dopamine is one of the key neurotransmitters in the central nervous system and plays an important role in physiological processes, as well as in the development of many diseases. Here we report a receptor-independent signalling pathway induced by dopamine in CNS neurons. In cultured neurons from midbrain, cortex and h...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2010.08.008
更新日期：2010-08-01 00:00:00
abstract：:Numerous lines of evidence indicate that nuclear calcium concentration ([Ca2+]n) may be controlled independently from cytosolic events by a local machinery. In particular, the perinuclear space between the inner nuclear membrane (INM) and the outer nuclear membrane (ONM) of the nuclear envelope (NE) likely serves as a...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.102143
更新日期：2020-03-01 00:00:00
abstract：:The regulation of cytosolic-free calcium concentration of smooth-muscle and endothelial cells was mainly studied on cultured cells where the cross talk between these two coupled cell types is lost. In the present study, the cytosolic-free calcium concentration in the endothelial and the smooth-muscle cells was examine...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.2001.0233
更新日期：2001-10-01 00:00:00
abstract：:Adipokinetic hormone (AKH)-induced mobilization of insect fat body glycogen occurs through activation of glycogen phosphorylase. In the migratory locust, signal transduction of AKH-I, -II and -III has been shown to involve the formation of cAMP. In the present study, we show that both the elevation of fat body cAMP le...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(95)90092-6
更新日期：1995-06-01 00:00:00
abstract：:Calcium and calcium-dependent systems have been long implicated in the induction of epilepsy. We have previously observed that intracellular calcium ([Ca2+]i) levels remain elevated in cells undergoing epileptogenesis in the hippocampal neuronal culture (HNC) model. In this study, we employed the hippocampal neuronal ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.2000.0146
更新日期：2000-09-01 00:00:00
abstract：:In the brain, classical (canonical) transient receptor potential (TRPC) channels are thought to be involved in different aspects of neuronal development. We investigated the developmental expression profile of TRPC channels in rat cerebellum during the first 6 weeks after birth. TRPC3 expression is significantly up-re...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2006.11.002
更新日期：2007-07-01 00:00:00
abstract：:The effects of the unsaturated fatty acids, arachidonic and oleic acid, on the influx of Ca2+ activated by depletion of intracellular stores with thapsigargin were investigated in various cell types. By using a Ca2+ free/Ca2+ reintroduction protocol, we observed that arachidonic acid (2 to 5 microM) inhibited thapsiga...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(97)90031-2
更新日期：1997-05-01 00:00:00
abstract：:The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by Ca...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2017.05.013
更新日期：2017-09-01 00:00:00
abstract：:Signaling between intracellular Ca2+ stores and cell membrane channels or transporters is important to Ca(2+)-based second messenger systems. Two hypotheses, the capacitative and the Ca(2+)-induced Ca(2+)-influx models have been proposed to explain aspects of this signaling. In this study, we examined the applicabilit...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90076-0
更新日期：1994-12-01 00:00:00
abstract：:Maitotoxin (MTX), a water-soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus increased intracellular calcium in a concentration-dependent manner in fibroblasts obtained from human skin. The effect of this toxin was both saturable and of high affinity, showing an apparent half activation co...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(97)90087-7
更新日期：1997-07-01 00:00:00
abstract：:An enzymatically active Ca2+-stimulated ATPase has been isolated from the sarcolemmal sheets of human smooth muscle (myometrium). Ca2+-ATPase activity was quantitated in an assay medium which simulated the characteristic free ionic concentrations of the cytosol. New computer programs for calculating the composition of...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(83)90001-5
更新日期：1983-10-01 00:00:00
abstract：:TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP) superfamily. This calcium-selective channel is highly expressed in the duodenum and the placenta, being responsible for calcium absorption in the body and fetus. Previous observations have suggested that TRPV6 is not only permeable...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2010.11.007
更新日期：2011-01-01 00:00:00
abstract：:A synthetic peptide (CaMBP) matching amino acids 3614-3643 of the skeletal ryanodine receptor (RyR1) binds to both Ca2+-free calmodulin (CaM) and Ca2+-bound CaM with nanomolar affinity [J. Biol. Chem. 276 (2001) 2069]. We report here that CaMBP increases [3H]ryanodine binding to RyR1 in a dose- and Ca2+-dependent mann...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2003.09.002
更新日期：2004-02-01 00:00:00
abstract：:Depletion of calcium in the extracellular medium used to incubate first trimester human placental minces resulted in a significant decrease in the quantity of immunoreactive hCG in the medium and a corresponding increase in the tissue. In contrast, when secretion of newly synthesised hCG was monitored in the absence o...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90060-j
更新日期：1993-09-01 00:00:00
abstract：:The importance of Ca(2+) signaling in astrocytes is undisputed but a potential role of Ca(2+) influx via L-channels in the brain in vivo is disputed, although expression of these channels in cultured astrocytes is recognized. This study shows that an increase in free cytosolic Ca(2+) concentration ([Ca(2+)]i) in astro...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2013.08.002
更新日期：2013-11-01 00:00:00
abstract：:Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch o...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2005.01.018
更新日期：2005-05-01 00:00:00
abstract：:Here we examine the potential coupling between the synthesis of secretory proteins and the sensitivity of exocytosis to the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)) in plant cell. We therefore monitor in tobacco protoplasts the excursion of the membrane capacitance in response to an elevation of [Ca(2...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2012.05.011
更新日期：2012-09-01 00:00:00
abstract：:Apparent calcium stability constants and the purity of Ca-chelating agents were evaluated using Ca(2+)-selective electrodes by the double-log optimization method [Oiki S. Yamamoto T. Okada Y. (1994) Cell Calcium, 15, 199-208]. The method was amended to allow evaluation of the free Ca2+ concentrations contaminating ele...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90060-4
更新日期：1994-03-01 00:00:00
abstract：:The effect of Ca2+ ion concentration on the 25 hydroxylation of tritiated cholecalciferol (3HD3) was investigated using homogenates of ovine liver from vitamin D replete sheep. A significant decrease in the production of 25 hydroxycholecalciferol (25OHD3) was observed when the concentration of Ca2+ in the homogenate w...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(87)90001-7
更新日期：1987-08-01 00:00:00
abstract：:In the presence of inositol (1,4,5)-trisphosphate (InsP3) repetitive waves of elevated cytosolic free Ca2+ (Ca waves) that travel through cellular cytoplasm are observed. Investigation of this phenomenon stimulated the view of cellular cytoplasm as 'an excitable medium composed of Ca release processes (InsP3R), couple...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90019-1
更新日期：1994-09-01 00:00:00
abstract：:The actions of the novel calcium (Ca2+) channel antagonist mibefradil (Ro 40-5967), a selective T-type channel blocker in myocardium, were investigated in embryonic rat spinal motoneurones maintained in culture. Whole-cell currents were recorded with the patch-clamp technique. Motoneurones displayed transient, low-vol...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(97)90068-3
更新日期：1997-10-01 00:00:00
