Abstract：
:Depletion of calcium in the extracellular medium used to incubate first trimester human placental minces resulted in a significant decrease in the quantity of immunoreactive hCG in the medium and a corresponding increase in the tissue. In contrast, when secretion of newly synthesised hCG was monitored in the absence of calcium by using a radioactive amino acid precursor, a significant increase in the secretion of newly synthesised hCG in the medium was noticed. This was true of secretion of other proteins also as evidenced by the increase in the trichloroacetic acid precipitable radioactivity in the medium in the absence of calcium. These results suggest that newly synthesised hCG is preferentially released over stored hormone in the absence of calcium.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Sharma SC,Rao AJdoi
10.1016/0143-4160(93)90060-jsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
601-7issue
8eissn
0143-4160issn
1532-1991pii
0143-4160(93)90060-Jjournal_volume
14pub_type
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