Abstract：
:The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In cerebellar Purkinje neurones, different levels of Ca2+ signalling have been observed that may involve the entire neurone or be spatially limited to fine dendritic structures. The Ca2+ signals accompanying subthreshold excitatory postsynaptic potentials resulting from stimulation of the excitatory parallel fibre input can be restricted to regions as small as a spiny dendrite or a single dendritic spine. With the recruitment of increasing numbers of inputs there is a summation of Ca2+ signals in highly restricted regions of the spiny dendrites that is independent of electrical summation at the soma. Of a number of potential sources that could provide the Ca2+ responsible for the postsynaptic changes, Ca2+ entry through voltage-gated Ca2+ channels has received the most support, although other sources like Ca2+ entry through ligand-gated channels and especially Ca2+ release from intracellular stores need to be considered.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Eilers J,Plant T,Konnerth Adoi
10.1016/s0143-4160(96)90108-6subject
Has Abstractpub_date
1996-08-01 00:00:00pages
215-26issue
2eissn
0143-4160issn
1532-1991pii
S0143-4160(96)90108-6journal_volume
20pub_type
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