Abstract：
:A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition, changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal content) or the magnitude of individual release events (quantal size) in both the short- and long-term. It is generally agreed that calcium achieves this regulation via an interaction with a number of different molecular targets located at or near to the site of membrane fusion. We review here the synaptic proteins with defined calcium-binding domains and protein kinases activated by calcium, summarize what is known about their function in membrane fusion and the experimental evidence in support of their involvement in synaptic plasticity.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Barclay JW,Morgan A,Burgoyne RDdoi
10.1016/j.ceca.2005.06.012keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
343-53issue
3-4eissn
0143-4160issn
1532-1991pii
S0143-4160(05)00099-0journal_volume
38pub_type
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