Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.

abstract：:We previously found in single channel studies that ryanodine receptor (RyR) channel activity can be made insensitive to block by Mg2+ when terminal cisternae of sarcoplasmic reticulum, incorporated into planar bilayers, are treated with protein kinase A (PKA) or Ca2+/calmodulin dependent protein kinase type II (CamPK ...

journal_title：Cell calcium

authors： Mayrleitner M,Chandler R,Schindler H,Fleischer S

更新日期：1995-09-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:The effect of Ca2+ ion concentration on the 25 hydroxylation of tritiated cholecalciferol (3HD3) was investigated using homogenates of ovine liver from vitamin D replete sheep. A significant decrease in the production of 25 hydroxycholecalciferol (25OHD3) was observed when the concentration of Ca2+ in the homogenate w...

journal_title：Cell calcium

authors： Corlett SC,Chaudhary MS,Tomlinson S,Care AD

更新日期：1987-08-01 00:00:00

abstract：:Indo-1 is a new fluorescent indicator of the intracellular free calcium concentration Cai++. Indo-1 may be used in a similar manner as its predecessor quin2 but offers the principal advantage that the Ca++ saturated form of the Ca++ chelator has a emission maximum different in wavelength from that of free indo-1 (400 ...

journal_title：Cell calcium

authors： Lückhoff A

更新日期：1986-08-01 00:00:00

abstract：:The effects of the unsaturated fatty acids, arachidonic and oleic acid, on the influx of Ca2+ activated by depletion of intracellular stores with thapsigargin were investigated in various cell types. By using a Ca2+ free/Ca2+ reintroduction protocol, we observed that arachidonic acid (2 to 5 microM) inhibited thapsiga...

journal_title：Cell calcium

authors： Gamberucci A,Fulceri R,Benedetti A

更新日期：1997-05-01 00:00:00

abstract：:Several proteins have been identified that associate with calcium release channels and potentially regulate their function. Using tacrolimus as a pharmacological tool, we investigated whether the immunophilin FKBP12 modulates ryanodine receptor channels in intestinal smooth muscle. Results with PCR demonstrated the pr...

journal_title：Cell calcium

authors： Bielefeldt K,Sharma RV,Whiteis C,Yedidag E,Abboud FM

更新日期：1997-12-01 00:00:00

abstract：:Increases in global Ca(2+) in the endothelium are a crucial step in releasing relaxing factors to modulate arterial tone. In the present study we investigated spontaneous Ca(2+) events in endothelial cells, and the contribution of smooth muscle cells to these Ca(2+) events, in pressurized rat mesenteric resistance art...

journal_title：Cell calcium

authors： Kansui Y,Garland CJ,Dora KA

更新日期：2008-08-01 00:00:00

abstract：:A variety of stimuli utilize an increase of cytosolic free Ca(2+) concentration as a second messenger to transmit signals, through Ca(2+) release from the endoplasmic reticulum or opening of plasma membrane Ca(2+) channels. Mitochondria contribute to the tight spatiotemporal control of this process by accumulating Ca(...

journal_title：Cell calcium

authors： Rasola A,Bernardi P

更新日期：2011-09-01 00:00:00

abstract：:The high capacity, low affinity Ca(2+) storage protein chromogranins are marker proteins of secretory granules that contain the most Ca(2+) in secretory cells. Along with the abundantly expressed chromogranins, the IP(3)R/Ca(2+) channels, the major intracellular Ca(2+) channels, are also expressed in secretory granule...

journal_title：Cell calcium

authors： Yoo SH,Hur YS

更新日期：2012-03-01 00:00:00

abstract：:The effects of the thyroid status on the Ca++-transporting capabilities of rat slow skeletal muscle (m.soleus) were studied. The oxalate supported Ca++-uptake activity and Ca++-loading capacity of muscle homogenates from hyperthyroid rats showed an approximate 4.2 and 2.5 fold increase, respectively, as compared to va...

journal_title：Cell calcium

authors： Simonides WS,van Hardeveld C

更新日期：1986-06-01 00:00:00

abstract：:Intracytoplasmic sperm injection (ICSI) into mammalian eggs induces repetitive rises in intracellular Ca2+ concentration ([Ca2+]i) which are the pivotal signal in fertilization. Spatiotemporal aspects of [Ca2+]i rises following ICSI into the periphery of mouse eggs were investigated with high-speed confocal microscopy...

journal_title：Cell calcium

authors： Sato MS,Yoshitomo M,Mohri T,Miyazaki S

更新日期：1999-07-01 00:00:00

abstract：:Odontoblasts are involved in the transduction of stimuli applied to exposed dentin. Although expression of thermo/mechano/osmo-sensitive transient receptor potential (TRP) channels has been demonstrated, the properties of TRP vanilloid 1 (TRPV1)-mediated signaling remain to be clarified. We investigated physiological ...

journal_title：Cell calcium

authors： Tsumura M,Sobhan U,Muramatsu T,Sato M,Ichikawa H,Sahara Y,Tazaki M,Shibukawa Y

更新日期：2012-08-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:In mammals Ca2+ concentration in the extracellular fluids ([Ca2+]o) is essential for a number of vital processes varying from bone mineralization to blood coagulation, regulation of enzymatic processes, modulation of permeability and excitability of plasma membranes. For this reason [Ca2+]o is under strict control of ...

journal_title：Cell calcium

authors： Riccardi D

更新日期：1999-09-01 00:00:00

abstract：:Cardiac muscle excitation-contraction coupling is controlled by the Ca(2+)-induced Ca2+ release mechanism. The present study examines the effects of a calmodulin antagonist W-7 on Ca2+ current (ICa)-induced Ca2+ release in whole cell-clamped rat ventricular myocytes. Exposure of cells to W-7 suppressed ICa, but the in...

journal_title：Cell calcium

authors： Suzuki YJ,Wang W,Morad M

更新日期：1999-03-01 00:00:00

abstract：:Cellular Ca2+ signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca2+ channels cause large fluctuations in local Ca2+ concentration (Ca2+ 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca2+-sensitive probes from attoliter volumes it has become poss...

journal_title：Cell calcium

authors： Swaminathan D,Dickinson GD,Demuro A,Parker I

更新日期：2020-03-01 00:00:00

abstract：:Three decades ago, James W. Putney Jr. conceptualized the idea of store-operated calcium entry (SOCE) to explain how depletion of endoplasmic reticulum (ER) Ca2+ stores evokes Ca2+ influx across the plasma membrane. Since the publication of this highly influential idea, it is now established that SOCE is universal amo...

journal_title：Cell calcium

authors： Yeung PS,Yamashita M,Prakriya M

更新日期：2017-05-01 00:00:00

abstract：:Ca2+ signalling governs stimulated exocytosis and exocytosis-coupled endocytosis also in Paramecium cells. Upon stimulation, the < or =10(3) dense-core exocytotic organelles (trichocysts) can be synchronously (80 ms) released, followed by endocytotic membrane resealing (350 ms) and retrieval. Paramecium is the most sy...

journal_title：Cell calcium

authors： Plattner H,Kissmehl R

更新日期：2005-09-01 00:00:00

abstract：:To determine the effects of exposure to reserpine on subcellular Ca2+ transporting systems, active Ca2+ uptake was measured with and without ruthenium red in submandibular gland vesicles obtained from rats after chronic treatment with reserpine. The properties of ruthenium red-sensitive Ca2+ uptake were similar to tho...

journal_title：Cell calcium

authors： Hurley TW,Martinez JR

更新日期：1987-10-01 00:00:00

abstract：:Ca(2+) signals are universal among cells in regulating a spectrum of cellular responses. Phospholipase C-coupled receptors activate two components of Ca(2+) signals--rapid Ca(2+) release from ER stores, followed by slower Ca(2+) entry from outside the cell. The coupling process between ER and PM to mediate this "store...

journal_title：Cell calcium

authors： Hewavitharana T,Deng X,Soboloff J,Gill DL

更新日期：2007-08-01 00:00:00

abstract：:The highly differentiated structure of the neuron poses special problems for the intracellular movement of molecules throughout the cell. Molecular transport distances from the synthesizing neuron cell body along the axon (which has no substantial synthetic capabilities) to the axon terminal are very great. The transp...

journal_title：Cell calcium

authors： Breuer AC,Atkinson MB

更新日期：1988-12-01 00:00:00

abstract：:It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...

journal_title：Cell calcium

authors： Kumar P,Brodie SG,Vaughan MK,Menendez-Pelaez A,Reiter RJ,Chambers JP

更新日期：1992-10-01 00:00:00

abstract：:In the brain, classical (canonical) transient receptor potential (TRPC) channels are thought to be involved in different aspects of neuronal development. We investigated the developmental expression profile of TRPC channels in rat cerebellum during the first 6 weeks after birth. TRPC3 expression is significantly up-re...

journal_title：Cell calcium

authors： Huang WC,Young JS,Glitsch MD

更新日期：2007-07-01 00:00:00

abstract：:To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms. Utilizing the electrophysiological technique of capacitance measurements as ...

journal_title：Cell calcium

authors： Hertelendy ZI,Patel DG,Knittel JJ

更新日期：1996-02-01 00:00:00

abstract：:The properties of the Ca2+, Mg2+-ATPase of erythrocyte membranes from patients with cystic fibrosis (CF) were extensively compared to that of healthy controls. Following removal of an endogenous membrane inhibitor of the ATPase, activation of the enzyme by Ca2+, calmodulin, limited tryptic digestion or oleic acid, as ...

journal_title：Cell calcium

authors： Waller RL,Johnson LR,Brattin WJ,Dearborn DG

更新日期：1985-06-01 00:00:00

abstract：:The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma...

journal_title：Cell calcium

authors： Ciappelloni S,Murphy-Royal C,Dupuis JP,Oliet SHR,Groc L

更新日期：2017-11-01 00:00:00

abstract：:The effect of the uterotonic pituitary hormone oxytocin on the regulation of intracellular calcium concentration ([Ca2+]i) was studied in single cells of a smooth muscle cell line derived from human non-pregnant myometrium. [Ca2+]i was measured with fluorescence microscopy, and by recording the activity of Ca(2+)-acti...

journal_title：Cell calcium

authors： Holda JR,Oberti C,Perez-Reyes E,Blatter LA

更新日期：1996-07-01 00:00:00

abstract：:The correlation between the intracellular Ca2+ concentration ([Ca2+]i) and membrane potential in monolayers of density-arrested normal rat kidney (NRK) fibroblasts was investigated. Using the fluorescent probe Fura-2, spontaneous repetitive spike-like increases in [Ca2+]i (Ca2+ spikes) were observed that were synchron...

journal_title：Cell calcium

authors： de Roos AD,Willems PH,Peters PH,van Zoelen EJ,Theuvenet AP

更新日期：1997-09-01 00:00:00

abstract：:The effect of furosemide and ouabain on the intracellular concentration of Ca2+ was studies in myocardial cell cultures using Fura-2, a fluorescent agent, as an intracellular Ca2+ indicator. Introduction of 200 microM ouabain to the cultured cells increased the intracellular calcium concentration from an average of 23...

journal_title：Cell calcium

authors： Rubin Y,Kessler-Icekson G,Navon G

更新日期：1995-08-01 00:00:00

abstract：:Mechanically induced channel activities and increase of intracellular calcium ([Ca2+]i) in normal and cancerous murine mammary cells (MMT 060562) were investigated using the patch clamp technique and Fura-2 fluorescence. Both cell types showed similar properties. Upon mechanical stimulation, activation of the Ca(2+)-d...

journal_title：Cell calcium

authors： Enomoto K,Furuya K,Yamagishi S,Maeno T

更新日期：1992-08-01 00:00:00