Abstract：
:The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma membrane of glial cells is still in its infancy. Yet, recent breakthroughs in the field of glial cells have been obtained using combination of superresolution microscopy, single molecule imaging, and electrophysiological recordings. Here, we review our current knowledge on the surface dynamics of neurotransmitter receptors, transporters and ion channels, in glial cells. It has emerged that the brain cell network activity, synaptic activity, and calcium signalling, regulate the surface distribution and dynamics of these molecules. Remarkably, the dynamics of a given neurotransmitter receptor/transporter at the plasma membrane of a glial cell or neuron is unique, revealing the existence of cell-type specific regulatory pathways. Thus, investigating the dynamics of signalling proteins at the surface of glial cells will likely shed new light on our understanding of glial cell physiology and pathology.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Ciappelloni S,Murphy-Royal C,Dupuis JP,Oliet SHR,Groc Ldoi
10.1016/j.ceca.2017.08.009subject
Has Abstractpub_date
2017-11-01 00:00:00pages
46-52eissn
0143-4160issn
1532-1991pii
S0143-4160(17)30154-9journal_volume
67pub_type
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