Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B.

abstract：:Both theoretical and experimental results are presented for in vivo calibration of the dissociation constant K(Ca)(d)of the calcium-sensitive fluorescent dye Rhod(2)in the perfused mouse heart, using manganese quenching of fluorescence transients. An analytical model is derived, based on the biochemical equilibrium of...

journal_title：Cell calcium

authors： Du C,MacGowan GA,Farkas DL,Koretsky AP

更新日期：2001-04-01 00:00:00

abstract：:Corticosteroid hormones, which are released in high amounts after stress, easily pass the blood-brain-barrier. In the brain they bind to intracellular receptors which act as transcriptional regulators. These receptors are highly expressed in neurons of the hippocampal formation and the amygdala, areas that play a role...

journal_title：Cell calcium

authors： Joëls M,Karst H

更新日期：2012-03-01 00:00:00

abstract：:Adipokinetic hormone (AKH)-induced mobilization of insect fat body glycogen occurs through activation of glycogen phosphorylase. In the migratory locust, signal transduction of AKH-I, -II and -III has been shown to involve the formation of cAMP. In the present study, we show that both the elevation of fat body cAMP le...

journal_title：Cell calcium

authors： Vroemen SF,Van Marrewijk WJ,Schepers CC,Van der Horst DJ

更新日期：1995-06-01 00:00:00

abstract：:Quartered pituitaries from castrated (72 h) +/- estradiol (E2)-treated (24 h) rats were used in a perifusion system to investigate estradiol modulation of ionomycin and ionomycin + PMA stimulated LH secretion. Estradiol enhanced the LH responses to GnRH (1 nM) and ionomycin (10 microM), and was necessary for the manif...

journal_title：Cell calcium

authors： Fahmy NW,Bourne GA

更新日期：1993-01-01 00:00:00

abstract：:Near-membrane [Ca2+] may differ significantly from bulk cytosolic [Ca2+], particularly during rapid Ca2+ signalling events related to cardiac muscle excitation-contraction coupling. We used the lipophilic membrane-associated Ca2+ indicator Ca(2+)-Green C-18 (C-18) and laser-scanning confocal microscopy to detect extra...

journal_title：Cell calcium

authors： Blatter LA,Niggli E

更新日期：1998-05-01 00:00:00

abstract：:The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. In...

journal_title：Cell calcium

authors： Wolkoff LI,Perrone RD,Grubman SA,Lee DW,Soltoff SP,Rogers LC,Beinborn M,Fang SL,Cheng SH,Jefferson DM

更新日期：1995-05-01 00:00:00

abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...

journal_title：Cell calcium

authors： Oheim M,Kirchhoff F,Stühmer W

更新日期：2006-11-01 00:00:00

abstract：:There is growing evidence indicating that the pore structure of voltage-gated ion channels (VGICs) influences gating besides their conductance. Regarding low voltage-activated (LVA) Ca2+ channels, it has been demonstrated that substitutions of the pore aspartate (D) by a glutamate (D-to-E substitution) in domains III ...

journal_title：Cell calcium

authors： Garza-López E,Aldana A,Darszon A,Nishigaki T,López-González I

更新日期：2020-07-01 00:00:00

abstract：:It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...

journal_title：Cell calcium

authors： Kumar P,Brodie SG,Vaughan MK,Menendez-Pelaez A,Reiter RJ,Chambers JP

更新日期：1992-10-01 00:00:00

abstract：:Cardiac muscle excitation-contraction coupling is controlled by the Ca(2+)-induced Ca2+ release mechanism. The present study examines the effects of a calmodulin antagonist W-7 on Ca2+ current (ICa)-induced Ca2+ release in whole cell-clamped rat ventricular myocytes. Exposure of cells to W-7 suppressed ICa, but the in...

journal_title：Cell calcium

authors： Suzuki YJ,Wang W,Morad M

更新日期：1999-03-01 00:00:00

abstract：:Incubation of human erythrocyte ghosts with an equal volume of 0.2 mM EDTA in isotonic KCl decreased both the activity and Ca2+ sensitivity of the (Ca2+ + Mg2+)-ATPase remaining associated with the membrane. Readdition of the EDTA-extract activated the (Ca2+ + Mg2+)-ATPase activity. The activator activity was trypsin ...

journal_title：Cell calcium

authors： Roufogalis BD,Elliott CT,Ralston GB

更新日期：1984-02-01 00:00:00

abstract：:Pancreatitis is an increasingly common disease that carries a significant mortality and which lacks specific therapy. Pathological calcium signalling is an important contributor to the initiating cell injury, caused by or acting through mitochondrial inhibition. A principal effect of disordered cell signalling and imp...

journal_title：Cell calcium

authors： Mukherjee R,Criddle DN,Gukovskaya A,Pandol S,Petersen OH,Sutton R

更新日期：2008-07-01 00:00:00

abstract：:An initial model has been proposed to describe a mechanism for cytosolic calcium oscillations [Jafri MS. Vajda S. Pasik P. Gillo B. (1992) A membrane model for cytosolic calcium oscillations: a study using Xenopus oocytes. Biophys. J., 63, 235-246]. In this paper we extend our original model to include the effects of ...

journal_title：Cell calcium

authors： Jafri MS,Gillo B

更新日期：1994-07-01 00:00:00

abstract：:Many fluorescent Ca indicators, particularly those loaded as acetoxymethyl (AM)-ester derivatives, are known to become compartmentalized into organelles. This property can be exploited to measure changes in free [Ca] in subcellular compartments, including the inositol (1,4,5)-trisphosphate-sensitive store. However, qu...

journal_title：Cell calcium

authors： Hofer AM,Schulz I

更新日期：1996-09-01 00:00:00

abstract：:The tissue/medium distribution of the nonmetabolized glucose analog [14C]-3-O-methyl-D-glucose was measured in pigeon erythrocytes and related to changes in 45Ca uptake and efflux, total calcium content and ATP levels. Sugar transport was not affected by changes in external Ca2+. However, both sugar and 45Ca influx we...

journal_title：Cell calcium

authors： Bihler I,Charles P,Sawh PC

更新日期：1982-08-01 00:00:00

abstract：:Ca2+ signals are known to mediate an array of cellular functions including secretion, contraction, and conductivity changes. In spite of the obvious role of Ca2+ in signalling, the control of Ca2+ within cells is known to be a complex phenomenon involving a number of distinct active and passive transport systems funct...

journal_title：Cell calcium

authors： Gill DL,Ghosh TK,Mullaney JM

更新日期：1989-07-01 00:00:00

abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...

journal_title：Cell calcium

authors： Shin HS

更新日期：2006-08-01 00:00:00

abstract：:The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) mediates increases in the intracellular concentration of Ca(2+) ([Ca(2+)]i) during fertilization in mammalian eggs. The activity of IP3R1 is enhanced during oocyte maturation, and phosphorylations by M-phase kinases are thought to positively regulate the activit...

journal_title：Cell calcium

authors： Zhang N,Yoon SY,Parys JB,Fissore RA

更新日期：2015-11-01 00:00:00

abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...

journal_title：Cell calcium

authors： Ong HL,Ambudkar IS

更新日期：2015-10-01 00:00:00

abstract：:The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regul...

journal_title：Cell calcium

authors： Marchi S,Patergnani S,Missiroli S,Morciano G,Rimessi A,Wieckowski MR,Giorgi C,Pinton P

更新日期：2018-01-01 00:00:00

abstract：:Mathematical models are often used to elucidate mechanisms behind cytosolic Ca2+ oscillations. We have evaluated the use of mathematical modelling to analyse and quantify Ca2+ signal patterns, in single, adherent human neutrophils (PMN) after stimulation by the bacterial peptide N-formyl-methionyl-leucyl-phenylalanine...

journal_title：Cell calcium

authors： Røtnes JS,Røttingen JA

更新日期：1994-06-01 00:00:00

abstract：:NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck in this basic research is due to NAADP, like all second messengers, being charged to prevent it from leaking out of cells. This...

journal_title：Cell calcium

authors： Parkesh R,Lewis AM,Aley PK,Arredouani A,Rossi S,Tavares R,Vasudevan SR,Rosen D,Galione A,Dowden J,Churchill GC

更新日期：2008-06-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MA...

journal_title：Cell calcium

authors： Karandikar M,Cobb MH

更新日期：1999-11-01 00:00:00

abstract：:Synaptic transmission is a key signaling event, whereby an action potential-induced release of chemical neurotransmitters again generates a positive or negative electrical activity via opening of postsynaptic channels. Thereafter, information spreads through space, from the postsynaptic membranes to the dendrites, to ...

journal_title：Cell calcium

authors： Bito H

更新日期：1998-02-01 00:00:00

abstract：:Calcium is a major intracellular signaling messenger in innate immune cells. Similar to other immune cell subsets, the majority of calcium entry into innate immune cells is induced by cell surface receptors that stimulate store-operated calcium entry through calcium-release activated calcium (CRAC) channels. Since the...

journal_title：Cell calcium

authors： Clemens RA,Lowell CA

更新日期：2019-03-01 00:00:00

abstract：:R24571 a derivative of the antimycotic miconazole, appears to be 5 to 8 times more potent than trifluoperazine in its ability to inhibit the calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum vesicles. The cAMP-dependent protein kinase mediated phosphorylation of cardiac sarcoplasmic reticulum was ...

journal_title：Cell calcium

authors： Louis CF,Turnquist J,Jarvis B

更新日期：1983-04-01 00:00:00

abstract：:NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca2+ ions through NMDARs, caused by an excessive activation of receptors, leads to excitotoxic neuronal cell death. Fo...

journal_title：Cell calcium

authors： Plutino S,Sciaccaluga M,Fucile S

更新日期：2019-06-01 00:00:00

abstract：:To characterize the effect that a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY294002, has on cytosolic calcium concentrations ([Ca2+]i), bovine airway smooth muscle cells (BASMC) and cultured human bronchial smooth muscle cells (HBSMC) were loaded with fura 2-AM, imaged as single cells and [Ca2+]i measured...

journal_title：Cell calcium

authors： Ethier MF,Madison JM

更新日期：2002-07-01 00:00:00

abstract：:A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recover...

journal_title：Cell calcium

authors： Koch KW

更新日期：1995-10-01 00:00:00