Control of photoreceptor proteins by Ca2+.

abstract：:In non-excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel playing a major role in Ca2+ signaling. Three isoforms of IP3R have been identified and most cell types express different proportions of each isoform. The DT40 B lymphocyte cell line lacking all three IP3R isoform...

journal_title：Cell calcium

authors： Guillemette J,Caron AZ,Regimbald-Dumas Y,Arguin G,Mignery GA,Boulay G,Guillemette G

更新日期：2005-02-01 00:00:00

abstract：:Extracellular nucleotides are potent Ca2+ mobilizing agents. A variety of receptors for extracellular ATP are recognised. Some are involved in fast neuronal transmission and operate as ligand-gated ion channels. Others are involved in the paracrine or autocrine modulation of cell function. Many receptors of this type ...

journal_title：Cell calcium

authors： Conigrave AD,Jiang L

更新日期：1995-02-01 00:00:00

abstract：:Under certain conditions of Ca2+ loading, cardiac myocytes, both isolated and in intact tissue, exhibit spontaneous, oscillatory Ca2+ transients due to Ca2+ release from the sarcoplasmic reticulum. These transients are not triggered by depolarization of the sarcolemma, though they themselves can generate depolarizing ...

journal_title：Cell calcium

authors： Stern MD,Capogrossi MC,Lakatta EG

更新日期：1988-12-01 00:00:00

abstract：:The effect of the uterotonic pituitary hormone oxytocin on the regulation of intracellular calcium concentration ([Ca2+]i) was studied in single cells of a smooth muscle cell line derived from human non-pregnant myometrium. [Ca2+]i was measured with fluorescence microscopy, and by recording the activity of Ca(2+)-acti...

journal_title：Cell calcium

authors： Holda JR,Oberti C,Perez-Reyes E,Blatter LA

更新日期：1996-07-01 00:00:00

abstract：:Endothelin-1 (ET-1), a potent vasoactive peptide with a pathogenic role in vascular diseases, has been shown to induce the activation of ERK1/2, PKB and the expression of a transcriptional regulator, the early growth response 1 (Egr-1), key mediators of hypertrophic and proliferative responses in vascular smooth muscl...

journal_title：Cell calcium

authors： Bouallegue A,Simo Cheyou ER,Anand-Srivastava MB,Srivastava AK

更新日期：2013-12-01 00:00:00

abstract：:The properties of the Ca2+, Mg2+-ATPase of erythrocyte membranes from patients with cystic fibrosis (CF) were extensively compared to that of healthy controls. Following removal of an endogenous membrane inhibitor of the ATPase, activation of the enzyme by Ca2+, calmodulin, limited tryptic digestion or oleic acid, as ...

journal_title：Cell calcium

authors： Waller RL,Johnson LR,Brattin WJ,Dearborn DG

更新日期：1985-06-01 00:00:00

abstract：:A whole range of cell functions are regulated by the free cytosolic Ca(2+)concentration. Activator Ca(2+)from the extracellular space enters the cell through various types of Ca(2+)channels and sometimes the Na(+)/Ca(2+)-exchanger, and is actively extruded from the cell by Ca(2+)pumps and Na(+)/Ca(2+)-exchangers. Acti...

journal_title：Cell calcium

authors： Missiaen L,Robberecht W,van den Bosch L,Callewaert G,Parys JB,Wuytack F,Raeymaekers L,Nilius B,Eggermont J,De Smedt H

更新日期：2000-07-01 00:00:00

abstract：:The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we di...

journal_title：Cell calcium

authors： Rorsman P,Braun M,Zhang Q

更新日期：2012-03-01 00:00:00

abstract：:Acidic organelles such as lysosomes serve as non-canonical Ca(2+) stores. The Ca(2+) mobilising messenger NAADP is thought to trigger local Ca(2+) release from such stores. These events are then amplified by Ca(2+) channels on canonical ER Ca(2+) stores to generate physiologically relevant global Ca(2+) signals. Coupl...

journal_title：Cell calcium

authors： Penny CJ,Kilpatrick BS,Eden ER,Patel S

更新日期：2015-10-01 00:00:00

abstract：:Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since ...

journal_title：Cell calcium

authors： Izquierdo-Torres E,Hernández-Oliveras A,Fuentes-García G,Zarain-Herzberg Á

更新日期：2020-11-01 00:00:00

abstract：:The measurement of intracellular calcium ion concentrations [( Ca2+]i) in single living cells using quantitative fluorescence microscopy draws from a diverse set of disciplines, including cellular biology, optical physics, statistics and computer science. Over the last few years, we have devised and built a number of ...

journal_title：Cell calcium

authors： Moore ED,Becker PL,Fogarty KE,Williams DA,Fay FS

更新日期：1990-02-01 00:00:00

abstract：:Removal of the epithelium from preparations of guinea-pig airways in vitro increases the responsiveness of the smooth muscle of normal and ovalbumin-sensitized animals to a number of contractile agents. To determine if epithelium removal results in an increase in Ca2+ entry into the smooth muscle, the effect of removi...

journal_title：Cell calcium

authors： Raeburn D,Hay DW,Fedan JS

更新日期：1987-12-01 00:00:00

abstract：:Human CD3-, CD16+ natural killer cells (NKs) induced necrosis in the cell line K562 and the minor population of MOLT-4, while induced apoptosis in the majority of MOLT-4, in one-to-one cell interaction. Simultaneous Ca2+ imaging of NK and target cells revealed remarkable differences in changes of cytosolic Ca2+ concen...

journal_title：Cell calcium

authors： Honda Y,Miyazaki S

更新日期：1996-04-01 00:00:00

abstract：:It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...

journal_title：Cell calcium

authors： Kumar P,Brodie SG,Vaughan MK,Menendez-Pelaez A,Reiter RJ,Chambers JP

更新日期：1992-10-01 00:00:00

abstract：:Muscarinic acetylcholine (ACh) receptors activate the phospholipase C signal transduction pathway to promote the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and the consequent elevation of cytoplasmic calcium (Ca2+). The inositol phosphate and Ca(2+)-mobilization responses to ACh were analyzed in Xenopus ...

journal_title：Cell calcium

authors： Ji H,Sandberg K,Bonner TI,Catt KJ

更新日期：1993-10-01 00:00:00

abstract：:The store-operated, calcium release-activated calcium current I(CRAC) is activated by the depletion of inositol 1,4,5-trisphosphate (IP(3))-sensitive stores. The significantly different dose-response relationships of IP(3)-mediated Ca(2+) release and CRAC channel activation indicate that I(CRAC) is activated by a func...

journal_title：Cell calcium

authors： Peinelt C,Beck A,Monteilh-Zoller MK,Penner R,Fleig A

更新日期：2009-04-01 00:00:00

abstract：:The actions of crude venom from Anemesia species of spider were investigated in cultured dorsal root ganglion neurones from neonatal rats and hippocampal slices. Using mass spectrometry (MALDI-TOF MS), 10-12 distinct peptides with masses between about 3 and 10kDa were identified in the crude spider venom. At a concent...

journal_title：Cell calcium

authors： Kalikulov D,Ayar A,Nuritova F,Frenguelli BG,McClelland D,Martin DJ,Davidson I,Scott RH

更新日期：2001-09-01 00:00:00

abstract：:Increases in global Ca(2+) in the endothelium are a crucial step in releasing relaxing factors to modulate arterial tone. In the present study we investigated spontaneous Ca(2+) events in endothelial cells, and the contribution of smooth muscle cells to these Ca(2+) events, in pressurized rat mesenteric resistance art...

journal_title：Cell calcium

authors： Kansui Y,Garland CJ,Dora KA

更新日期：2008-08-01 00:00:00

abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...

journal_title：Cell calcium

authors： Samtleben S,Wachter B,Blum R

更新日期：2015-08-01 00:00:00

abstract：:Vesl/Homer proteins physically link proteins that mediate cellular signaling [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851] and thereby influence cellular function [Nat. Neurosci. 4 (2001) 499; Nature 411 (2001) 962]. A previous study reported that Vesl-1L/Homer-1c ...

journal_title：Cell calcium

authors： Hwang SY,Wei J,Westhoff JH,Duncan RS,Ozawa F,Volpe P,Inokuchi K,Koulen P

更新日期：2003-08-01 00:00:00

abstract：:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to ...

journal_title：Cell calcium

authors： Malviya AN

更新日期：1994-10-01 00:00:00

abstract：:In the cochlea, cell damage triggers intercellular Ca2+ waves that propagate through the glial-like supporting cells that surround receptor hair cells. These Ca2+ waves are thought to convey information about sensory hair cell-damage to the surrounding supporting cells within the cochlear epithelium. Mitochondria are ...

journal_title：Cell calcium

authors： Mann ZF,Duchen MR,Gale JE

更新日期：2009-08-01 00:00:00

abstract：:In addition to its role in artery contraction, Rho kinase (ROCK) is reported to be involved in the Ca(2+) response to vasoconstrictor agonist in rat aorta. However the signaling pathway mediated by ROCK had not been investigated so far and it was not known whether ROCK also contributed to Ca(2+) signaling in cultured ...

journal_title：Cell calcium

authors： Martinsen A,Baeyens N,Yerna X,Morel N

更新日期：2012-12-01 00:00:00

abstract：:To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms. Utilizing the electrophysiological technique of capacitance measurements as ...

journal_title：Cell calcium

authors： Hertelendy ZI,Patel DG,Knittel JJ

更新日期：1996-02-01 00:00:00

abstract：:A possible role of the nitric oxide (NO)/cGMP pathway in the regulation of Ca2+ entry into HT29/B6 human colonic epithelial cells was investigated using digital image processing of Fura-2 fluorescence and immunoblotting for nitric oxide synthase (NOS). We tested the hypothesis that Ca2+ store depletion causes increase...

journal_title：Cell calcium

authors： Bischof G,Brenman J,Bredt DS,Machen TE

更新日期：1995-04-01 00:00:00

abstract：:A characteristic feature of developing neural networks is spontaneous periodic activity. In the developing retina, retinal ganglion cells fire bursts of action potentials that drive large increases in intracellular calcium concentration with a periodicity of minutes. These periodic bursts of action potentials propagat...

journal_title：Cell calcium

authors： Firth SI,Wang CT,Feller MB

更新日期：2005-05-01 00:00:00

abstract：:The control of calcium homeostasis is essential for cell survival and is of crucial importance for several physiological functions. The discovery of the epithelial calcium channel Transient Receptor Potential Vaniloid (TRPV6) in intestine has uncovered important Ca(2+) absorptive pathways involved in the regulation of...

journal_title：Cell calcium

authors： Irnaten M,Blanchard-Gutton N,Harvey BJ

更新日期：2008-11-01 00:00:00

abstract：:The regulation of cytosolic-free calcium concentration of smooth-muscle and endothelial cells was mainly studied on cultured cells where the cross talk between these two coupled cell types is lost. In the present study, the cytosolic-free calcium concentration in the endothelial and the smooth-muscle cells was examine...

journal_title：Cell calcium

authors： Oishi H,Budel S,Schuster A,Stergiopulos N,Meister JJ,Bény JL

更新日期：2001-10-01 00:00:00

abstract：:The strength of the heart beat depends on the amplitude and time course of the transient increase in [Ca(2+)] in the myocytes with each cycle. [Na(+)](i) modulates cardiac contraction through its effect on the Ca(2+) flux through the Na/Ca exchanger. Cardiac excitation-contraction coupling has been postulated to occur...

journal_title：Cell calcium

authors： Verdonck F,Mubagwa K,Sipido KR

更新日期：2004-06-01 00:00:00

abstract：:Membrane deformation induced by a mechanical stimulus increases the [Ca2+]i in cultured retinal pigment epithelial (RPE) cells, and in many other cell types. In this study, confocal microscopy and Ca(2+)-measurements using the fluorescent dye fluo-3 were used to measure the spatiotemporal characteristics of the Ca(2+)...

journal_title：Cell calcium

authors： Stalmans P,Himpens B

更新日期：1999-06-01 00:00:00