Venom from Anemesia species of spider modulates high voltage-activated Ca(2+) currents from rat cultured sensory neurones and excitatory post synaptic currents from rat hippocampal slices.

abstract：:Store-operated Ca2+ entry (SOCE), an important Ca2+ signaling pathway in non-excitable cells, regulates a variety of cellular functions. To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-APB is one of the best characterized SOCE inhibitors. H...

journal_title：Cell calcium

authors： Bittremieux M,Gerasimenko JV,Schuermans M,Luyten T,Stapleton E,Alzayady KJ,De Smedt H,Yule DI,Mikoshiba K,Vangheluwe P,Gerasimenko OV,Parys JB,Bultynck G

更新日期：2017-03-01 00:00:00

abstract：:In non-excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel which plays a major role in Ca2+ signalling. Three isoforms of IP3R have been identified (IP3R-1, IP3R-2 and IP3R-3) and most cell types express different proportions of each isoform. The differences between the p...

journal_title：Cell calcium

authors： Caron AZ,Chaloux B,Arguin G,Guillemette G

更新日期：2007-09-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:A whole range of cell functions are regulated by the free cytosolic Ca(2+)concentration. Activator Ca(2+)from the extracellular space enters the cell through various types of Ca(2+)channels and sometimes the Na(+)/Ca(2+)-exchanger, and is actively extruded from the cell by Ca(2+)pumps and Na(+)/Ca(2+)-exchangers. Acti...

journal_title：Cell calcium

authors： Missiaen L,Robberecht W,van den Bosch L,Callewaert G,Parys JB,Wuytack F,Raeymaekers L,Nilius B,Eggermont J,De Smedt H

更新日期：2000-07-01 00:00:00

abstract：:An influx of Ca2+ into red blood cells of the bivalve mollusc Noetia ponderosa occurs immediately following a hypo-osmotic stress. The volume recovery response to the stress is dependent upon [Ca2+]o and is inhibited by phenothiazines. The action of these drugs is on the amino acid regulation portion of the recovery r...

journal_title：Cell calcium

authors： Pierce SK,Politis AD,Cronkite DH,Rowland LM,Smith LH Jr

更新日期：1989-04-01 00:00:00

abstract：:We have examined the internal Ca(2+)-dependence of the long-term evolution of whole cell high voltage activated Ca current in chromaffin cells. The evolution of the peak Ca current was characterized by 2 distinct phases: after an initial facilitation, there followed a rundown, which represented a reduction by 70% with...

journal_title：Cell calcium

authors： Elhamdani A,Bossu JL,Feltz A

更新日期：1994-11-01 00:00:00

abstract：:The effect of furosemide and ouabain on the intracellular concentration of Ca2+ was studies in myocardial cell cultures using Fura-2, a fluorescent agent, as an intracellular Ca2+ indicator. Introduction of 200 microM ouabain to the cultured cells increased the intracellular calcium concentration from an average of 23...

journal_title：Cell calcium

authors： Rubin Y,Kessler-Icekson G,Navon G

更新日期：1995-08-01 00:00:00

abstract：:Extracellular nucleotides are potent Ca2+ mobilizing agents. A variety of receptors for extracellular ATP are recognised. Some are involved in fast neuronal transmission and operate as ligand-gated ion channels. Others are involved in the paracrine or autocrine modulation of cell function. Many receptors of this type ...

journal_title：Cell calcium

authors： Conigrave AD,Jiang L

更新日期：1995-02-01 00:00:00

abstract：:TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP) superfamily. This calcium-selective channel is highly expressed in the duodenum and the placenta, being responsible for calcium absorption in the body and fetus. Previous observations have suggested that TRPV6 is not only permeable...

journal_title：Cell calcium

authors： Kovacs G,Danko T,Bergeron MJ,Balazs B,Suzuki Y,Zsembery A,Hediger MA

更新日期：2011-01-01 00:00:00

abstract：:While genetically encoded Ca(2+) indicators (GECIs) allow Ca(2+) imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the inte...

journal_title：Cell calcium

authors： Wong SS,Kotera I,Mills E,Suzuki H,Truong K

更新日期：2012-01-01 00:00:00

abstract：:A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recover...

journal_title：Cell calcium

authors： Koch KW

更新日期：1995-10-01 00:00:00

abstract：:Inhibition by Mg2+ ions of exocytotic secretion from permeabilised eosinophils, stimulated by Ca2+ and GTP gamma S, and in the presence and absence of ATP, has been examined. While Mg2+ inhibits release of aryl sulphatase, hexosaminidase and peroxidase, we found no evidence that this occurs by competition at a Ca(2+)-...

journal_title：Cell calcium

authors： Larbi KY,Gomperts BD

更新日期：1997-03-01 00:00:00

abstract：:TRPA1, a Ca(2+)-permeable cation channel that is expressed in sensory neurones, is involved in the perception of chemical irritants and mechanical hyperalgesia. TRPA1 is activated by either covalent or reversible binding of various chemical compounds, including allylisothiocyanate or acrolein, and is further sensitise...

journal_title：Cell calcium

authors： Hill K,Schaefer M

更新日期：2009-02-01 00:00:00

abstract：:The effect of Ca2+ ion concentration on the 25 hydroxylation of tritiated cholecalciferol (3HD3) was investigated using homogenates of ovine liver from vitamin D replete sheep. A significant decrease in the production of 25 hydroxycholecalciferol (25OHD3) was observed when the concentration of Ca2+ in the homogenate w...

journal_title：Cell calcium

authors： Corlett SC,Chaudhary MS,Tomlinson S,Care AD

更新日期：1987-08-01 00:00:00

abstract：:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to ...

journal_title：Cell calcium

authors： Malviya AN

更新日期：1994-10-01 00:00:00

abstract：:Maitotoxin (MTX), a water-soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus increased intracellular calcium in a concentration-dependent manner in fibroblasts obtained from human skin. The effect of this toxin was both saturable and of high affinity, showing an apparent half activation co...

journal_title：Cell calcium

authors： Gutierrez D,Díaz de León L,Vaca L

更新日期：1997-07-01 00:00:00

abstract：:Secretory granules of pancreatic β-cells contain high concentrations of Ca2+ ions that are co-released with insulin in the extracellular milieu upon activation of exocytosis. As a consequence, an increase in the extracellular Ca2+ concentration ([Ca2+]ext) in the microenvironment immediately surrounding β-cells should...

journal_title：Cell calcium

authors： Gerbino A,Maiellaro I,Carmone C,Caroppo R,Debellis L,Barile M,Busco G,Colella M

更新日期：2012-05-01 00:00:00

abstract：:As pivotal players in cellular metabolism, mitochondria have a double-faceted role in the final decision of cell fate. This is true for all cell types, but it is even more important and intriguing in the cancer setting. Mitochondria regulate cell fate in many diverse ways: through metabolism, by producing ATP and othe...

journal_title：Cell calcium

authors： Genovese I,Vezzani B,Danese A,Modesti L,Vitto VAM,Corazzi V,Pelucchi S,Pinton P,Giorgi C

更新日期：2020-12-01 00:00:00

abstract：:Hepatocytes stimulated with calcium-mobilising agonists generate free Ca transients whose frequency is modulated by hormone concentration. Importantly, the time-course of individual free Ca transients is independent of agonist dose but does change with agonist species. A receptor-controlled model in which protein kina...

journal_title：Cell calcium

authors： Cobbold PH,Sanchez-Bueno A,Dixon CJ

更新日期：1991-02-01 00:00:00

abstract：:Synaptic transmission is a key signaling event, whereby an action potential-induced release of chemical neurotransmitters again generates a positive or negative electrical activity via opening of postsynaptic channels. Thereafter, information spreads through space, from the postsynaptic membranes to the dendrites, to ...

journal_title：Cell calcium

authors： Bito H

更新日期：1998-02-01 00:00:00

abstract：:Cyclic AMP regulates the late step of Ca²+-dependent exocytosis in many secretory cells through two major mechanisms: a protein kinase A-dependent and a cAMP-GEF/Epac-dependent pathway. We designed a protocol to characterize the role of these two cAMP-dependent pathways on the Ca²+ sensitivity and kinetics of regulate...

journal_title：Cell calcium

authors： Skelin M,Rupnik M

更新日期：2011-02-01 00:00:00

abstract：:Membrane deformation induced by a mechanical stimulus increases the [Ca2+]i in cultured retinal pigment epithelial (RPE) cells, and in many other cell types. In this study, confocal microscopy and Ca(2+)-measurements using the fluorescent dye fluo-3 were used to measure the spatiotemporal characteristics of the Ca(2+)...

journal_title：Cell calcium

authors： Stalmans P,Himpens B

更新日期：1999-06-01 00:00:00

abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...

journal_title：Cell calcium

authors： Ong HL,Ambudkar IS

更新日期：2015-10-01 00:00:00

abstract：:Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...

journal_title：Cell calcium

authors： Harrington MA,Thompson SH

更新日期：1996-05-01 00:00:00

abstract：:We studied the contribution of store-operated or capacitative Ca2+-entry (SOCE or CCE, respectively) through store-operated Ca2+ channels (SOCCs) and the contribution of Ca2+-entry through receptor-operated, non-selective cation channels (ROCCs or NSCCs, respectively), on the M3-receptor-mediated (270 nM Ach) contract...

journal_title：Cell calcium

authors： Weirich J,Dumont L,Fleckenstein-Grün G

更新日期：2005-11-01 00:00:00

abstract：:The regulation of cytosolic-free calcium concentration of smooth-muscle and endothelial cells was mainly studied on cultured cells where the cross talk between these two coupled cell types is lost. In the present study, the cytosolic-free calcium concentration in the endothelial and the smooth-muscle cells was examine...

journal_title：Cell calcium

authors： Oishi H,Budel S,Schuster A,Stergiopulos N,Meister JJ,Bény JL

更新日期：2001-10-01 00:00:00

abstract：:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...

journal_title：Cell calcium

authors： Pavlovic D

更新日期：2020-03-01 00:00:00

abstract：:The highly differentiated structure of the neuron poses special problems for the intracellular movement of molecules throughout the cell. Molecular transport distances from the synthesizing neuron cell body along the axon (which has no substantial synthetic capabilities) to the axon terminal are very great. The transp...

journal_title：Cell calcium

authors： Breuer AC,Atkinson MB

更新日期：1988-12-01 00:00:00

abstract：:The effect of the uterotonic pituitary hormone oxytocin on the regulation of intracellular calcium concentration ([Ca2+]i) was studied in single cells of a smooth muscle cell line derived from human non-pregnant myometrium. [Ca2+]i was measured with fluorescence microscopy, and by recording the activity of Ca(2+)-acti...

journal_title：Cell calcium

authors： Holda JR,Oberti C,Perez-Reyes E,Blatter LA

更新日期：1996-07-01 00:00:00

abstract：:A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition, changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal content) or the magnitude of individual release events (quantal size) in both the short- and long-term. It is generally agreed that ...

journal_title：Cell calcium

authors： Barclay JW,Morgan A,Burgoyne RD

更新日期：2005-09-01 00:00:00