Abstract：
:Synaptic transmission is a key signaling event, whereby an action potential-induced release of chemical neurotransmitters again generates a positive or negative electrical activity via opening of postsynaptic channels. Thereafter, information spreads through space, from the postsynaptic membranes to the dendrites, to the soma, to the nucleus, to the presynaptic terminals and, in some cases, back to the originally stimulated synapses. Furthermore, information is also often converted in time, either by shifting the phase of electrical activity during the integration of EPSPs and IPSPs into the generation of an action potential, or by triggering a long-lasting cascade of enzymatic or protein-protein interaction-mediated events in the cytoplasm and in the nucleus. Recent studies of the signaling from the synapse to the nucleus now allow us to consider how various patterns of synaptic activity could couple with activation of specific nuclear transcription factors and thus regulate neuronal gene expression. The critical importance of Ca(2+)-dependent signaling processes in such regulatory events will be discussed below.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Bito Hdoi
10.1016/s0143-4160(98)90113-0subject
Has Abstractpub_date
1998-02-01 00:00:00pages
143-50issue
2-3eissn
0143-4160issn
1532-1991pii
S0143-4160(98)90113-0journal_volume
23pub_type
杂志文章,评审相关文献
CELL CALCIUM文献大全abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2007.05.010
更新日期：2007-10-01 00:00:00
abstract：:Ca2+ influx into secretory cells of the intact salivary gland of the blowfly Calliphora erythrocephala elicited by the agonist 5-hydroxytryptamine (5-HT) or the Ca2+ uptake inhibitor thapsigargin was studied by using Fura-2 and digital fluorescence imaging and by recordings of the transepithelial potential. Applicatio...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(98)90074-4
更新日期：1998-01-01 00:00:00
abstract：:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90094-9
更新日期：1994-10-01 00:00:00
abstract：:The strength of the heart beat depends on the amplitude and time course of the transient increase in [Ca(2+)] in the myocytes with each cycle. [Na(+)](i) modulates cardiac contraction through its effect on the Ca(2+) flux through the Na/Ca exchanger. Cardiac excitation-contraction coupling has been postulated to occur...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2004.01.014
更新日期：2004-06-01 00:00:00
abstract：:In skeletal muscle excitation-contraction (EC) coupling the sarcolemmal L-type Ca(2+) channel or 1,4-dihydropyridine receptor (DHPR) transduces the membrane depolarization signal to the sarcoplasmic Ca(2+) release channel RyR1 via protein-protein interaction. While it is evident that the pore-forming and voltage-sensi...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2010.04.003
更新日期：2010-06-01 00:00:00
abstract：:When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(90)90008-i
更新日期：1990-04-01 00:00:00
abstract：:The mammalian transient receptor potential (TRP) proteins consist of a superfamily of Ca2+-permeant non-selective cation channels with structural similarities to Drosophila TRP. The TRP superfamily can be divided into three major families, among them the "canonical TRP" family (TRPC). The seven protein products of the...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/s0143-4160(03)00056-3
更新日期：2003-05-01 00:00:00
abstract：:Extracellular nucleotides are potent Ca2+ mobilizing agents. A variety of receptors for extracellular ATP are recognised. Some are involved in fast neuronal transmission and operate as ligand-gated ion channels. Others are involved in the paracrine or autocrine modulation of cell function. Many receptors of this type ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/0143-4160(95)90080-2
更新日期：1995-02-01 00:00:00
abstract：:Many fluorescent Ca indicators, particularly those loaded as acetoxymethyl (AM)-ester derivatives, are known to become compartmentalized into organelles. This property can be exploited to measure changes in free [Ca] in subcellular compartments, including the inositol (1,4,5)-trisphosphate-sensitive store. However, qu...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(96)90029-9
更新日期：1996-09-01 00:00:00
abstract：:Vesl/Homer proteins physically link proteins that mediate cellular signaling [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851] and thereby influence cellular function [Nat. Neurosci. 4 (2001) 499; Nature 411 (2001) 962]. A previous study reported that Vesl-1L/Homer-1c ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(03)00082-4
更新日期：2003-08-01 00:00:00
abstract：:Changes in the concentration and spatial distribution of Ca(2+) ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca(2+) dyes that allow direct visualization of Ca(2+) transients, combined with powerful experimental tools such as electrophysiologica...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2010.10.003
更新日期：2010-11-01 00:00:00
abstract：:Both theoretical and experimental results are presented for in vivo calibration of the dissociation constant K(Ca)(d)of the calcium-sensitive fluorescent dye Rhod(2)in the perfused mouse heart, using manganese quenching of fluorescence transients. An analytical model is derived, based on the biochemical equilibrium of...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.2000.0186
更新日期：2001-04-01 00:00:00
abstract：:The sphingosine derivatives sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) caused a similar elevation of the intracellular Ca2+ concentration ([Ca2+]i) in an immortalized airway epithelial cell line (CFNP9o-) incubated in Ca(2+)-free medium. The maximal effect was obtained with 2 microM SPC and 0....
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(98)90095-1
更新日期：1998-06-01 00:00:00
abstract：:Calcium release-activated calcium (CRAC) channels have been the target of drug discovery for many years. The identification of STIM and Orai proteins as key components of CRAC channels greatly facilitated this process because their co-expression in cell lines produced electrophysiological currents (ICRAC) much larger ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2018.07.005
更新日期：2018-09-01 00:00:00
abstract：:Nanosecond-duration electric stimuli are distinguished by the ability to permeabilize intracellular membranes and recruit Ca2+ from intracellular stores. We quantified this effect in non-excitable cells (CHO) using ratiometric Ca2+ imaging with Fura-2. In a Ca(2+)-free medium, 10-, 60-, and 300-ns stimuli evoked Ca2+ ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2013.05.008
更新日期：2013-09-01 00:00:00
abstract：:The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2017.08.009
更新日期：2017-11-01 00:00:00
abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2006.08.007
更新日期：2006-11-01 00:00:00
abstract：:The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regul...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2017.05.003
更新日期：2018-01-01 00:00:00
abstract：:Quartered pituitaries from castrated (72 h) +/- estradiol (E2)-treated (24 h) rats were used in a perifusion system to investigate estradiol modulation of ionomycin and ionomycin + PMA stimulated LH secretion. Estradiol enhanced the LH responses to GnRH (1 nM) and ionomycin (10 microM), and was necessary for the manif...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90015-x
更新日期：1993-01-01 00:00:00
abstract：:Isolated avian growth plate chondrocytes convert the acetoxymethyl ester (AM) form of Fura-2 quickly and efficiently to the Ca2(+)-sensitive pentacarboxylic acid (FA) form. Control experiments indicate that the Kd for intracellular Fura-2/FA is very close to that of extracellular Fura-2/FA at the same ionic strength a...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(90)90077-8
更新日期：1990-08-01 00:00:00
abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2008.01.004
更新日期：2008-10-01 00:00:00
abstract：:Pancreatic islets produce pulses of insulin and other hormones that maintain normal glucose homeostasis. These micro-organs possess exquisite glucose-sensing capabilities, allowing for precise changes in pulsatile insulin secretion in response to small changes in glucose. When communication among these cells is disrup...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.102081
更新日期：2019-11-01 00:00:00
abstract：:A potential role of arachidonic acid in the modulation of insulin secretion was investigated by measuring its effects on calmodulin-dependent protein kinase and protein kinase C in islet subcellular fractions. The results were interpreted in the light of arachidonic acid effects on insulin secretion from intact islets...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(92)90044-s
更新日期：1992-03-01 00:00:00
abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2015.04.002
更新日期：2015-08-01 00:00:00
abstract：:Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2011.02.001
更新日期：2011-03-01 00:00:00
abstract：:It has been reported that leukotriene B4 can translocate calcium across model membranes (Serhan et. al., (1982) J. Biol. Chem., 257: 4746). Such ionophoretic behavior could account for its biological effects. We have examined the effect of chromatographically pure leukotriene B4 on Ca2+ permeability when added exogeno...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(87)90028-5
更新日期：1987-12-01 00:00:00
abstract：:Cardiac muscle excitation-contraction coupling is controlled by the Ca(2+)-induced Ca2+ release mechanism. The present study examines the effects of a calmodulin antagonist W-7 on Ca2+ current (ICa)-induced Ca2+ release in whole cell-clamped rat ventricular myocytes. Exposure of cells to W-7 suppressed ICa, but the in...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.1998.0019
更新日期：1999-03-01 00:00:00
abstract：:Cellular redox status is maintained by the balance between series of antioxidant systems and production of reactive oxygen/nitrogenous species. Cells utilize this redox balance to mediate diverse physiological functions. Transient receptor potential (TRP) channels are non-selective cation channels that act as biosenso...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2016.02.009
更新日期：2016-08-01 00:00:00
abstract：:Here, we report a novel role for the cysteine protease calpain in store-operated calcium entry. Several structurally and mechanistically unrelated inhibitors of calpain inhibited Ca2+ entry activated in human platelets by thapsigargin-evoked Ca2+ store depletion or the physiological agonist thrombin, whereas inhibitor...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2006.05.008
更新日期：2007-02-01 00:00:00
abstract：:Studies were conducted using normal and human papillomavirus Type 18 (HPV-18) immortalized human keratinocytes to assess possible alterations in the differentiation process as a consequence of increased intracellular calcium concentration. Normal keratinocytes exposed to increased extracellular calcium or the phorbol ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(91)90050-o
更新日期：1991-05-01 00:00:00
