Failure of leukotriene B4 to translocate calcium across phosphatidylcholine membranes.

abstract：:The A23187 induced calcium uptake in ATP depleted cells was determined at pH 6.9 in the presence of trifluoperazine (TFP, 0.30 mM), compound 48/80 (0.89 mg/ml), 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8, 2.13 mM) and verapamil (1.81 mM). Apart from verapamil the drugs all increased the maximum rate of ...

journal_title：Cell calcium

authors： Foder B,Skibsted U,Scharff O

更新日期：1984-10-01 00:00:00

abstract：:NAADP is a potent regulator of cytosolic calcium levels. Much evidence suggests that NAADP activates a novel channel located on an acidic (lysosomal-like) calcium store, the mobilisation of which results in further calcium release from the endoplasmic reticulum. Here, we discuss the recent identification of a family o...

journal_title：Cell calcium

authors： Patel S,Marchant JS,Brailoiu E

更新日期：2010-06-01 00:00:00

abstract：:Specific Ca(2+) homeostatic system appeared very early in the history of the cell, as a survival system preventing Ca(2+)-mediated cell damage. This homeostatic system produced a steep ( approximately 20,000 times) concentration gradient between extracellular and intracellular compartments, which has both survival imp...

journal_title：Cell calcium

authors： Case RM,Eisner D,Gurney A,Jones O,Muallem S,Verkhratsky A

更新日期：2007-10-01 00:00:00

abstract：:The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma...

journal_title：Cell calcium

authors： Ciappelloni S,Murphy-Royal C,Dupuis JP,Oliet SHR,Groc L

更新日期：2017-11-01 00:00:00

abstract：:Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial fibrillation. Due to their ability to bind and inhibit the ubiquitou...

journal_title：Cell calcium

authors： Pavlovic D

更新日期：2020-03-01 00:00:00

abstract：:Ca2+ signalling governs stimulated exocytosis and exocytosis-coupled endocytosis also in Paramecium cells. Upon stimulation, the < or =10(3) dense-core exocytotic organelles (trichocysts) can be synchronously (80 ms) released, followed by endocytotic membrane resealing (350 ms) and retrieval. Paramecium is the most sy...

journal_title：Cell calcium

authors： Plattner H,Kissmehl R

更新日期：2005-09-01 00:00:00

abstract：:The effects of the thyroid status on the Ca++-transporting capabilities of rat slow skeletal muscle (m.soleus) were studied. The oxalate supported Ca++-uptake activity and Ca++-loading capacity of muscle homogenates from hyperthyroid rats showed an approximate 4.2 and 2.5 fold increase, respectively, as compared to va...

journal_title：Cell calcium

authors： Simonides WS,van Hardeveld C

更新日期：1986-06-01 00:00:00

abstract：:Both theoretical and experimental results are presented for in vivo calibration of the dissociation constant K(Ca)(d)of the calcium-sensitive fluorescent dye Rhod(2)in the perfused mouse heart, using manganese quenching of fluorescence transients. An analytical model is derived, based on the biochemical equilibrium of...

journal_title：Cell calcium

authors： Du C,MacGowan GA,Farkas DL,Koretsky AP

更新日期：2001-04-01 00:00:00

abstract：:MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MA...

journal_title：Cell calcium

authors： Karandikar M,Cobb MH

更新日期：1999-11-01 00:00:00

abstract：:Recent developments in microscopy and fluorescent indicators now make it possible to monitor the activity and localization of membrane ion channels by imaging Ca(2+) flux through individual channels. Such optical approaches have advantages over electrophysiological single-channel techniques in that they are less invas...

journal_title：Cell calcium

authors： Shuai J,Parker I

更新日期：2005-04-01 00:00:00

abstract：:We have investigated the effects of glucose on cytosolic free calcium concentration in the insulin-secreting cell line HIT-T15. Addition of glucose (10 mM) caused a 20-75% increase in cytosolic [Ca2+] within 5 minutes compared to controls in the absence of glucose. A maximal increase in cytosolic [Ca2+] was obtained w...

journal_title：Cell calcium

authors： Meats JE,Best L,Lynch AM,Tomlinson S

更新日期：1989-11-01 00:00:00

abstract：:Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...

journal_title：Cell calcium

authors： Harrington MA,Thompson SH

更新日期：1996-05-01 00:00:00

abstract：:Calcium dependence of bleb formation and cell death was evaluated in rat hepatocytes following ATP depletion by metabolic inhibition with KCN and iodoacetate ('chemical hypoxia'). Cytosolic free Ca2+ was measured in single cells by ratio imaging of Fura-2 fluorescence using multiparameter digitized video microscopy. C...

journal_title：Cell calcium

authors： Nieminen AL,Gores GJ,Wray BE,Tanaka Y,Herman B,Lemasters JJ

更新日期：1988-12-01 00:00:00

abstract：:A 106 kD protein was isolated from skeletal sarcoplasmic reticulum (SR) vesicles and shown to have the properties of SR Ca2+ release channels, including blockade by 5 nM ryanodine. In view of extensive reports that the ryanodine-receptor complex consists of four 565 kD junctional feet proteins (JFPs) and is the 'physi...

journal_title：Cell calcium

authors： Salama G,Nigam M,Shome K,Finkel MS,Lagenaur C,Zaidi NF

更新日期：1992-11-01 00:00:00

abstract：:Mechanically induced channel activities and increase of intracellular calcium ([Ca2+]i) in normal and cancerous murine mammary cells (MMT 060562) were investigated using the patch clamp technique and Fura-2 fluorescence. Both cell types showed similar properties. Upon mechanical stimulation, activation of the Ca(2+)-d...

journal_title：Cell calcium

authors： Enomoto K,Furuya K,Yamagishi S,Maeno T

更新日期：1992-08-01 00:00:00

abstract：:A possible role of the nitric oxide (NO)/cGMP pathway in the regulation of Ca2+ entry into HT29/B6 human colonic epithelial cells was investigated using digital image processing of Fura-2 fluorescence and immunoblotting for nitric oxide synthase (NOS). We tested the hypothesis that Ca2+ store depletion causes increase...

journal_title：Cell calcium

authors： Bischof G,Brenman J,Bredt DS,Machen TE

更新日期：1995-04-01 00:00:00

abstract：:TRP family of proteins are components of unique cation channels that are activated in response to diverse stimuli ranging from growth factor and neurotransmitter stimulation of plasma membrane receptors to a variety of chemical and sensory signals. This review will focus on members of the TRPC sub-family (TRPC1-TRPC7)...

journal_title：Cell calcium

authors： Ambudkar IS,Bandyopadhyay BC,Liu X,Lockwich TP,Paria B,Ong HL

更新日期：2006-11-01 00:00:00

abstract：:The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In ...

journal_title：Cell calcium

authors： Eilers J,Plant T,Konnerth A

更新日期：1996-08-01 00:00:00

abstract：:In skeletal muscle excitation-contraction (EC) coupling the sarcolemmal L-type Ca(2+) channel or 1,4-dihydropyridine receptor (DHPR) transduces the membrane depolarization signal to the sarcoplasmic Ca(2+) release channel RyR1 via protein-protein interaction. While it is evident that the pore-forming and voltage-sensi...

journal_title：Cell calcium

authors： Dayal A,Schredelseker J,Franzini-Armstrong C,Grabner M

更新日期：2010-06-01 00:00:00

abstract：:A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recover...

journal_title：Cell calcium

authors： Koch KW

更新日期：1995-10-01 00:00:00

abstract：:The rat parotid salivary gland shows marked alterations in phospholipid metabolism when stimulated by certain agonists. These agonists are those which cause cellular Ca mobilization by activation of muscarinic, alpha-adrenergic or peptidergic (substance P) receptors. The phospholipid changes apparently reflect the act...

journal_title：Cell calcium

authors： Putney JW Jr

更新日期：1982-10-01 00:00:00

abstract：:When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...

journal_title：Cell calcium

authors： Kaneko S,Doi E,Watanabe H,Nomura Y

更新日期：1990-04-01 00:00:00

abstract：:The oscillations in cytosolic Ca2+ evoked in pancreatic exocrine acinar cells by submaximal concentrations of the two phosphoinositidase-coupled agonists acetylcholine (ACh) and cholecystokinin octapeptide (CCK-8) have very different temporal patterns. In the present study we use digital video imaging of Fura-2 fluore...

journal_title：Cell calcium

authors： Lawrie AM,Toescu EC,Gallacher DV

更新日期：1993-11-01 00:00:00

abstract：:The activation of T lymphocytes, like many cells, requires a rapid rise in intracellular Ca2+ secondary to both an influx and a release from intracellular stores. The latter is activated by inositol-1,4,5-trisphosphate [Ins(1,4,5)P3]. It is controversial if inositol phosphates can also stimulate a plasma membrane Ca2+...

journal_title：Cell calcium

authors： O'Riordan C,Rosoff PM

更新日期：1993-02-01 00:00:00

abstract：:Here, we report a novel role for the cysteine protease calpain in store-operated calcium entry. Several structurally and mechanistically unrelated inhibitors of calpain inhibited Ca2+ entry activated in human platelets by thapsigargin-evoked Ca2+ store depletion or the physiological agonist thrombin, whereas inhibitor...

journal_title：Cell calcium

authors： Harper AG,Sage SO

更新日期：2007-02-01 00:00:00

abstract：:Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane...

journal_title：Cell calcium

authors： Morgan BP,Luzio JP,Campbell AK

更新日期：1986-12-01 00:00:00

abstract：:Intercellular Ca(2+)-signaling, after mechanical stimulation of calf pulmonary artery endothelial cells (CPAE), was investigated with fluorescence video imaging. Mechanical stimulation evoked an intracellular Ca(2+)-response in the mechanically stimulated (MS) cell, proceeding to the neighboring (NB) cells as a Ca(2+)...

journal_title：Cell calcium

authors： Moerenhout M,Himpens B,Vereecke J

更新日期：2001-02-01 00:00:00

abstract：:Intracellular Ca(2+)-transport ATPases exert a pivotal role in the endoplasmic reticulum and in the compartments of the cellular secretory pathway by maintaining a sufficiently high lumenal Ca(2+) (and Mn(2+)) concentration in these compartments required for an impressive number of vastly different cell functions. At ...

journal_title：Cell calcium

authors： Wuytack F,Raeymaekers L,Missiaen L

更新日期：2002-11-01 00:00:00

abstract：:One of the important events during hypoxia or ischemia in the brain (or other organs for that matter, including the myocardium) is the accumulation of Ca2+ ions intracellularly. Although various studies have shown various sources of and routes for Ca2+ entry and accumulation, it is clear now that it is likely that the...

journal_title：Cell calcium

authors： Yao H,Haddad GG

更新日期：2004-09-01 00:00:00

abstract：:Ca2+ pumps are essential for removing cytosolic Ca2+ either across the plasma membrane (PM) or into internal organelles such as the sarcoplasmic reticulum (SR). Four genes (PMCA1, PMCA2, PMCA3 and PMCA4) have been reported to encode the PM Ca2+ pumps and three (SERCA1, SERCA2 and SERCA3) to encode the SR Ca2+ pumps. T...

journal_title：Cell calcium

authors： Grover AK,Khan I

更新日期：1992-01-01 00:00:00