Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling.

abstract：:Fura-2 fluorescence imaging was used to measure changes in intracellular Ca2+ concentration in individual N1E-115 neuroblastoma cells during repeated activation of M1 muscarinic receptors with carbachol. Ca2+ transients could be elicited repeatedly at 4 min intervals with little decrement as long as external Ca2+ was ...

journal_title：Cell calcium

authors： Harrington MA,Thompson SH

更新日期：1996-05-01 00:00:00

abstract：:The A23187 induced calcium uptake in ATP depleted cells was determined at pH 6.9 in the presence of trifluoperazine (TFP, 0.30 mM), compound 48/80 (0.89 mg/ml), 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8, 2.13 mM) and verapamil (1.81 mM). Apart from verapamil the drugs all increased the maximum rate of ...

journal_title：Cell calcium

authors： Foder B,Skibsted U,Scharff O

更新日期：1984-10-01 00:00:00

abstract：:Mechanically induced channel activities and increase of intracellular calcium ([Ca2+]i) in normal and cancerous murine mammary cells (MMT 060562) were investigated using the patch clamp technique and Fura-2 fluorescence. Both cell types showed similar properties. Upon mechanical stimulation, activation of the Ca(2+)-d...

journal_title：Cell calcium

authors： Enomoto K,Furuya K,Yamagishi S,Maeno T

更新日期：1992-08-01 00:00:00

abstract：:The present study was undertaken to determine in fetal rat osteoblasts whether and how the intracellular messengers calcium and cAMP are involved in stimulation of ornithine decarboxylase (ODC) activity. For that purpose we used different drugs affecting [Ca2+]i and cAMP concentration. A23187 stimulates ODC activity i...

journal_title：Cell calcium

authors： van Leeuwen JP,Bos MP,Herrmann-Erlee MP

更新日期：1988-08-01 00:00:00

abstract：:The regulation of the Ca2+ -induced Ca2+ release (CICR) from intracellular stores is a critical step in the cardiac cycle. The inherent positive feedback of CICR should make it a self-regenerating process. It is accepted that CICR must be governed by some negative control, but its nature is still debated. We explore h...

journal_title：Cell calcium

authors： Zoghbi ME,Copello JA,Villalba-Galea CA,Vélez P,Diaz Sylvester PL,Bolaños P,Marcano A,Fill M,Escobar AL

更新日期：2004-08-01 00:00:00

abstract：:Ca(2+) is known as a universal messenger mediating a wide variety of cellular processes, including cell death. In fact, this ion has been proposed as the 'cell death master', not only at the intracellular but also at the intercellular level. The most direct form of intercellular spread of cell death is mediated by gap...

journal_title：Cell calcium

authors： Decrock E,Vinken M,Bol M,D'Herde K,Rogiers V,Vandenabeele P,Krysko DV,Bultynck G,Leybaert L

更新日期：2011-09-01 00:00:00

abstract：:C3H/10T1/2 mouse embryo fibroblasts stimulated by a steady electric field (10 V/cm) for 30 min exhibited lamellar retraction on the sides facing the electrodes. Some cells elongated and preferentially oriented with their long axis perpendicular to the field direction. Depletion of external calcium or blockage of calci...

journal_title：Cell calcium

authors： Onuma EK,Hui SW

更新日期：1985-06-01 00:00:00

abstract：:Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections are associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying novel targets/pathways required for MERS infectivity is therefore important for developing novel therapeutics. As an enveloped virus, translocation thr...

journal_title：Cell calcium

authors： Gunaratne GS,Yang Y,Li F,Walseth TF,Marchant JS

更新日期：2018-11-01 00:00:00

abstract：:We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit ...

journal_title：Cell calcium

authors： Molski TF,Naccache PH,Sha'afi RI

更新日期：1983-02-01 00:00:00

abstract：:T-type Ca(2+) channel family includes three subunits Ca(V)3.1, Ca(V)3.2 and Ca(V)3.3 and have been shown to control burst firing and intracellular Ca(2+) concentration ([Ca(2+)](i)) in neurons. Here, we investigated whether Ca(V)3.1 channels could generate a pacemaker current and contribute to cell excitability. Ca(V)...

journal_title：Cell calcium

authors： Chevalier M,Mironneau C,Macrez N,Quignard JF

更新日期：2008-12-01 00:00:00

abstract：:Odontoblasts are involved in the transduction of stimuli applied to exposed dentin. Although expression of thermo/mechano/osmo-sensitive transient receptor potential (TRP) channels has been demonstrated, the properties of TRP vanilloid 1 (TRPV1)-mediated signaling remain to be clarified. We investigated physiological ...

journal_title：Cell calcium

authors： Tsumura M,Sobhan U,Muramatsu T,Sato M,Ichikawa H,Sahara Y,Tazaki M,Shibukawa Y

更新日期：2012-08-01 00:00:00

abstract：:Secretory granules of pancreatic β-cells contain high concentrations of Ca2+ ions that are co-released with insulin in the extracellular milieu upon activation of exocytosis. As a consequence, an increase in the extracellular Ca2+ concentration ([Ca2+]ext) in the microenvironment immediately surrounding β-cells should...

journal_title：Cell calcium

authors： Gerbino A,Maiellaro I,Carmone C,Caroppo R,Debellis L,Barile M,Busco G,Colella M

更新日期：2012-05-01 00:00:00

abstract：:The calcium release channel/ryanodine receptor of rabbit skeletal muscle sarcoplasmic reticulum is tightly associated with the immunophilin FK-506 binding protein (FKBP-12). The immunosuppressant drug FK-506 effectively dissociates FKBP-12 from the calcium release channel of terminal cisternae (TC) vesicles. Furthermo...

journal_title：Cell calcium

authors： Mayrleitner M,Timerman AP,Wiederrecht G,Fleischer S

更新日期：1994-02-01 00:00:00

abstract：:The effect of Ca2+ ion concentration on the 25 hydroxylation of tritiated cholecalciferol (3HD3) was investigated using homogenates of ovine liver from vitamin D replete sheep. A significant decrease in the production of 25 hydroxycholecalciferol (25OHD3) was observed when the concentration of Ca2+ in the homogenate w...

journal_title：Cell calcium

authors： Corlett SC,Chaudhary MS,Tomlinson S,Care AD

更新日期：1987-08-01 00:00:00

abstract：:Dopamine is one of the key neurotransmitters in the central nervous system and plays an important role in physiological processes, as well as in the development of many diseases. Here we report a receptor-independent signalling pathway induced by dopamine in CNS neurons. In cultured neurons from midbrain, cortex and h...

journal_title：Cell calcium

authors： Vaarmann A,Gandhi S,Gourine AV,Abramov AY

更新日期：2010-08-01 00:00:00

abstract：:Factors contributing to "local control" of Ca2+ release in cardiac myocytes are incompletely understood. We induced local release of Ca2+ by regional exposure of mouse atrial and ventricular myocytes to 10mM caffeine for 500 ms using a rapid solution switcher. Propagation of Ca2+ release was imaged by means of a Nipko...

journal_title：Cell calcium

authors： Seguchi H,Ritter M,Shizukuishi M,Ishida H,Chokoh G,Nakazawa H,Spitzer KW,Barry WH

更新日期：2005-07-01 00:00:00

abstract：:Palmitoylation (S-acylation) is the reversible conjugation of a fatty acid (usually C16 palmitate) to intracellular cysteine residues of proteins via a thioester linkage. Palmitoylation anchors intracellular regions of proteins to membranes because the palmitoylated cysteine is recruited to the lipid bilayer. NCX1 is ...

journal_title：Cell calcium

authors： Gök C,Fuller W

更新日期：2020-03-01 00:00:00

abstract：:Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na(+)-Ca2+ exchanger (NCX1) to correlate suppression of the Na(+)-Ca2+ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both...

journal_title：Cell calcium

authors： Egger M,Porzig H,Niggli E,Schwaller B

更新日期：2005-03-01 00:00:00

abstract：:Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and envir...

journal_title：Cell calcium

authors： Medic N,Desai A,Komarow H,Burch LH,Bandara G,Beaven MA,Metcalfe DD,Gilfillan AM

更新日期：2011-11-01 00:00:00

abstract：:Photolysis of caged calcium (Nitr5, Calbiochem) can be used to study calcium dependent processes such as excitation-contraction coupling and muscular mechanics. Expensive high energy light sources are routinely used for UV light exposure, but this study describes an alternative low cost xenon flash unit constructed in...

journal_title：Cell calcium

authors： Van Koeveringe GA,Van Mastrigt R

更新日期：1994-05-01 00:00:00

abstract：:The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In ...

journal_title：Cell calcium

authors： Eilers J,Plant T,Konnerth A

更新日期：1996-08-01 00:00:00

abstract：:Calcium release-activated calcium (CRAC) channels have been the target of drug discovery for many years. The identification of STIM and Orai proteins as key components of CRAC channels greatly facilitated this process because their co-expression in cell lines produced electrophysiological currents (ICRAC) much larger ...

journal_title：Cell calcium

authors： Stauderman KA

更新日期：2018-09-01 00:00:00

abstract：:We have examined the internal Ca(2+)-dependence of the long-term evolution of whole cell high voltage activated Ca current in chromaffin cells. The evolution of the peak Ca current was characterized by 2 distinct phases: after an initial facilitation, there followed a rundown, which represented a reduction by 70% with...

journal_title：Cell calcium

authors： Elhamdani A,Bossu JL,Feltz A

更新日期：1994-11-01 00:00:00

abstract：:Mammalian homologues of the Drosophila transient receptor potential channel (TRPC) are involved in Ca(2+) entry following agonist stimulation of nonexcitable cells. Seven mammalian TRPCs have been cloned but their mechanisms of activation and/or regulation are still the subject of intense research efforts. It has alre...

journal_title：Cell calcium

authors： Boulay G

更新日期：2002-10-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...

journal_title：Cell calcium

authors： Medic N,Desai A,Olivera A,Abramowitz J,Birnbaumer L,Beaven MA,Gilfillan AM,Metcalfe DD

更新日期：2013-05-01 00:00:00

abstract：:Cardiogenesis depends on a tightly regulated balance between proliferation and differentiation of cardiac progenitor cells (CPCs) and their cardiomyocyte descendants. While exposure of early mouse embryos to Ca(2+) channel antagonists has been associated with abnormal cardiac morphogenesis, less is known about the con...

journal_title：Cell calcium

authors： Hotchkiss A,Feridooni T,Zhang F,Pasumarthi KB

更新日期：2014-05-01 00:00:00

abstract：:The concentration of free Ca2+ in the cytoplasm and organelles of individual mouse pancreatic beta-cells was estimated with dual wavelength microfluorometry and the indicators Fura-2 and furaptra. Measuring the increase of cytoplasmic Ca2+ resulting from intracellular mobilization of the ion in ob/ob mouse beta-cells,...

journal_title：Cell calcium

authors： Tengholm A,Hellman B,Gylfe E

更新日期：2000-01-01 00:00:00

abstract：:Fluorescent calcium indicators have been widely used to assess cytoplasmic calcium concentration in cells. To examine the role of calcium ions on different physiological functions (e.g. in case of liver; bile secretion, glucose metabolism, etc.) there is a need for whole organ studies. We have developed a technique to...

journal_title：Cell calcium

authors： Ruttner Z,Ligeti L,Reinlib L,Hines K,McLaughlin AC

更新日期：1993-06-01 00:00:00

abstract：:Synaptic transmission is a key signaling event, whereby an action potential-induced release of chemical neurotransmitters again generates a positive or negative electrical activity via opening of postsynaptic channels. Thereafter, information spreads through space, from the postsynaptic membranes to the dendrites, to ...

journal_title：Cell calcium

authors： Bito H

更新日期：1998-02-01 00:00:00