Abstract：
:The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regulate essential functions, including metabolism, energy production and apoptosis. Here, we will describe the different molecular players involved in the transfer of Ca2+ ions from the ER lumen to the mitochondrial matrix and how modifications in both ER-mitochondria contact sites and Ca2+ signaling can alter the cell death execution program.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Marchi S,Patergnani S,Missiroli S,Morciano G,Rimessi A,Wieckowski MR,Giorgi C,Pinton Pdoi
10.1016/j.ceca.2017.05.003subject
Has Abstractpub_date
2018-01-01 00:00:00pages
62-72eissn
0143-4160issn
1532-1991pii
S0143-4160(17)30062-3journal_volume
69pub_type
杂志文章,评审相关文献
CELL CALCIUM文献大全abstract：:The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) mediates increases in the intracellular concentration of Ca(2+) ([Ca(2+)]i) during fertilization in mammalian eggs. The activity of IP3R1 is enhanced during oocyte maturation, and phosphorylations by M-phase kinases are thought to positively regulate the activit...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2015.07.004
更新日期：2015-11-01 00:00:00
abstract：:An enzymatically active Ca2+-stimulated ATPase has been isolated from the sarcolemmal sheets of human smooth muscle (myometrium). Ca2+-ATPase activity was quantitated in an assay medium which simulated the characteristic free ionic concentrations of the cytosol. New computer programs for calculating the composition of...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(83)90001-5
更新日期：1983-10-01 00:00:00
abstract：:Capacitative calcium entry is a process whereby the depletion of Ca(2+) from intracellular stores (likely endoplasmic or sarcoplasmic reticulum) activates plasma membrane Ca(2+) channels. Current research has focused on identification of capacitative calcium entry channels and the mechanism by which Ca(2+) store deple...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/s0143-4160(03)00143-x
更新日期：2003-10-01 00:00:00
abstract：:When the concentrations of either calcium or of magnesium in the culture medium were increased from the normal 0.6 and 1.0 mM to 1.8 and 2.5 mM respectively mitotic activity of rat thymic lymphocytes increased. Very high (10(-4)M) ouabain concentrations abolished these mitogenic actions whilst lower (10(-7) and 10(-11...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(83)90044-1
更新日期：1983-02-01 00:00:00
abstract：:IP3R is located to the inner nuclear membrane. Nuclear IP3R is recognized as a 220 kD immunoreactive protein by antisera raised against purified rat brain IP3R. Antisera against C-terminal 95-108 peptide fragment derived from rat brain IP3R does not reveal immunoreactivity in the nucleus. Nuclear IP3R is sensitive to ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(94)90094-9
更新日期：1994-10-01 00:00:00
abstract：:Although store-operated calcium entry (SOCE) was identified more that two decades ago, understanding the molecular mechanisms that regulate and mediate this process continue to pose a major challenge to investigators in this field. Thus, there has been major focus on determining which of the models proposed for this m...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2007.01.013
更新日期：2007-08-01 00:00:00
abstract：:Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]i) were monitored optically in hair cells mechanically isolated from frog semicircular canals using the membrane-impermeant form of the Ca(2+)-selective dye Oregon Green 488 BAPTA-1 (OG, 100 microM). Cells stimulated by depolarization under whole-cell voltage cla...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1054/ceca.2001.0220
更新日期：2001-08-01 00:00:00
abstract：:The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2017.08.009
更新日期：2017-11-01 00:00:00
abstract：:The highly differentiated structure of the neuron poses special problems for the intracellular movement of molecules throughout the cell. Molecular transport distances from the synthesizing neuron cell body along the axon (which has no substantial synthetic capabilities) to the axon terminal are very great. The transp...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(88)90010-3
更新日期：1988-12-01 00:00:00
abstract：:It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(92)90036-r
更新日期：1992-10-01 00:00:00
abstract：:The ability of the ectodermal cells to be induced and to differentiate toward neural tissue, called neural competence, is acquired shortly before gastrulation and lost during late gastrula stages in Pleurodeles waltl embryos. We have examined ectodermal cells' neural competence in relation to the evolution of the dens...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(95)90036-5
更新日期：1995-03-01 00:00:00
abstract：:Mechanically induced channel activities and increase of intracellular calcium ([Ca2+]i) in normal and cancerous murine mammary cells (MMT 060562) were investigated using the patch clamp technique and Fura-2 fluorescence. Both cell types showed similar properties. Upon mechanical stimulation, activation of the Ca(2+)-d...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(92)90018-n
更新日期：1992-08-01 00:00:00
abstract：:The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we di...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2011.11.006
更新日期：2012-03-01 00:00:00
abstract：:Quartered pituitaries from castrated (72 h) +/- estradiol (E2)-treated (24 h) rats were used in a perifusion system to investigate estradiol modulation of ionomycin and ionomycin + PMA stimulated LH secretion. Estradiol enhanced the LH responses to GnRH (1 nM) and ionomycin (10 microM), and was necessary for the manif...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(93)90015-x
更新日期：1993-01-01 00:00:00
abstract：:Indo-1 is a new fluorescent indicator of the intracellular free calcium concentration Cai++. Indo-1 may be used in a similar manner as its predecessor quin2 but offers the principal advantage that the Ca++ saturated form of the Ca++ chelator has a emission maximum different in wavelength from that of free indo-1 (400 ...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(86)90003-5
更新日期：1986-08-01 00:00:00
abstract：:The actions of the novel calcium (Ca2+) channel antagonist mibefradil (Ro 40-5967), a selective T-type channel blocker in myocardium, were investigated in embryonic rat spinal motoneurones maintained in culture. Whole-cell currents were recorded with the patch-clamp technique. Motoneurones displayed transient, low-vol...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143-4160(97)90068-3
更新日期：1997-10-01 00:00:00
abstract：:Mammalian homologues of the Drosophila transient receptor potential channel (TRPC) are involved in Ca(2+) entry following agonist stimulation of nonexcitable cells. Seven mammalian TRPCs have been cloned but their mechanisms of activation and/or regulation are still the subject of intense research efforts. It has alre...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/s0143416002001550
更新日期：2002-10-01 00:00:00
abstract：:Great insight has been gained into the structure and function of the inositol 1,4,5 trisphosphate receptor (InsP(3)R) by studies employing mutagenesis of the cDNA encoding the receptor. Notably, early studies using this approach defined the key constituents required for InsP(3) binding in the N-terminus and the membra...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2010.04.005
更新日期：2010-06-01 00:00:00
abstract：:Low-voltage-activated T-type calcium channels are expressed in various tissues, especially in the brain, where they promote neuronal firing and are involved in slow wave sleep and absence epilepsy. While the transduction pathways by which hormones and neurotransmitters modulate high-voltage-activated calcium channels ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2006.04.015
更新日期：2006-08-01 00:00:00
abstract：:Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2007.10.003
更新日期：2008-06-01 00:00:00
abstract：:A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recover...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/0143-4160(95)90027-6
更新日期：1995-10-01 00:00:00
abstract：:Endothelin-1 (ET-1), a potent vasoactive peptide with a pathogenic role in vascular diseases, has been shown to induce the activation of ERK1/2, PKB and the expression of a transcriptional regulator, the early growth response 1 (Egr-1), key mediators of hypertrophic and proliferative responses in vascular smooth muscl...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2013.10.002
更新日期：2013-12-01 00:00:00
abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2007.05.010
更新日期：2007-10-01 00:00:00
abstract：:Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/0143-4160(86)90042-4
更新日期：1986-12-01 00:00:00
abstract：:Cellular redox status is maintained by the balance between series of antioxidant systems and production of reactive oxygen/nitrogenous species. Cells utilize this redox balance to mediate diverse physiological functions. Transient receptor potential (TRP) channels are non-selective cation channels that act as biosenso...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/j.ceca.2016.02.009
更新日期：2016-08-01 00:00:00
abstract：:Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing second messenger which triggers Ca2+ release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding protein has not been identified and the regulation of NAADP mediated Ca2+ release remains controversial. To address...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2019.102060
更新日期：2019-11-01 00:00:00
abstract：:Removal of the epithelium from preparations of guinea-pig airways in vitro increases the responsiveness of the smooth muscle of normal and ovalbumin-sensitized animals to a number of contractile agents. To determine if epithelium removal results in an increase in Ca2+ entry into the smooth muscle, the effect of removi...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(87)90026-1
更新日期：1987-12-01 00:00:00
abstract：:We have investigated the effects of glucose on cytosolic free calcium concentration in the insulin-secreting cell line HIT-T15. Addition of glucose (10 mM) caused a 20-75% increase in cytosolic [Ca2+] within 5 minutes compared to controls in the absence of glucose. A maximal increase in cytosolic [Ca2+] was obtained w...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/0143-4160(89)90015-8
更新日期：1989-11-01 00:00:00
abstract：:TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP) superfamily. This calcium-selective channel is highly expressed in the duodenum and the placenta, being responsible for calcium absorption in the body and fetus. Previous observations have suggested that TRPV6 is not only permeable...
journal_title：Cell calcium
pub_type： 杂志文章
doi：10.1016/j.ceca.2010.11.007
更新日期：2011-01-01 00:00:00
abstract：:Hepatocytes stimulated with calcium-mobilising agonists generate free Ca transients whose frequency is modulated by hormone concentration. Importantly, the time-course of individual free Ca transients is independent of agonist dose but does change with agonist species. A receptor-controlled model in which protein kina...
journal_title：Cell calcium
pub_type： 杂志文章,评审
doi：10.1016/0143-4160(91)90011-3
更新日期：1991-02-01 00:00:00
