Abstract：
:The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Rorsman P,Braun M,Zhang Qdoi
10.1016/j.ceca.2011.11.006subject
Has Abstractpub_date
2012-03-01 00:00:00pages
300-8issue
3-4eissn
0143-4160issn
1532-1991pii
S0143-4160(11)00223-5journal_volume
51pub_type
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