Abstract：
:In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca(2+) plays a significant role. This is supported not only by evidence linking alterations in Ca(2+) homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also by recent data indicating that a key anti-apoptotic protein, Bcl-2, has a direct effect on ER Ca(2+) handling. We will briefly summarise the first aspect, and describe in more detail these new data, demonstrating that (i) Bcl-2 reduces the state of filling of the ER Ca(2+) store and (ii) this Ca(2+) signalling alteration renders the cells less sensitive to apoptotic stimuli. Overall, these results suggest that calcium homeostasis may represent a pharmacological target in the fundamental pathological process of apoptosis.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Ferrari D,Pinton P,Szabadkai G,Chami M,Campanella M,Pozzan T,Rizzuto Rdoi
10.1016/s0143416002002014keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
413-20issue
5-6eissn
0143-4160issn
1532-1991pii
S0143416002002014journal_volume
32pub_type
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