Calcium release from ryanodine receptors in the nucleoplasmic reticulum.

abstract：:P2Y(12) antagonists such as clopidogrel and AR-C69931MX inhibit aggregation by antagonizing the effects of ADP at P2Y(12) receptors on platelets. Agents such as PGE(1) also inhibit aggregation by stimulating adenylate cyclase to produce cAMP, which interferes with Ca(2+) mobilization within the cell. Since one facet o...

journal_title：Cell calcium

authors： Fox SC,Behan MW,Heptinstall S

更新日期：2004-01-01 00:00:00

abstract：:We report here the first local and global Ca(2+) measurements made from in situ terminal arterioles. The advantages of the method are that there is minimal disturbance to the vessels, which retain their relationship to the tissue they are supplying (rat ureter) and the small size of vessel that can be studied. Good lo...

journal_title：Cell calcium

authors： Burdyga T,Shmygol A,Eisner DA,Wray S

更新日期：2003-07-01 00:00:00

abstract：:Ca(2+) influx through voltage-gated Ca(2+) channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribb...

journal_title：Cell calcium

authors： Cho S,von Gersdorff H

更新日期：2012-09-01 00:00:00

abstract：:NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca2+ ions through NMDARs, caused by an excessive activation of receptors, leads to excitotoxic neuronal cell death. Fo...

journal_title：Cell calcium

authors： Plutino S,Sciaccaluga M,Fucile S

更新日期：2019-06-01 00:00:00

abstract：:An inward current responsible for hormone regulated Ca2+ entry has been identified in cultured rat hepatocytes using whole cell patch clamp. Addition of 20 nM vasopressin or of 100 microM ATP induced the inward current, which could be observed more clearly after blocking an outward K+ current. This large outward K+ cu...

journal_title：Cell calcium

authors： Duszynski J,Elensky M,Cheung JY,Tillotson DL,LaNoue KF

更新日期：1995-07-01 00:00:00

abstract：:To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms. Utilizing the electrophysiological technique of capacitance measurements as ...

journal_title：Cell calcium

authors： Hertelendy ZI,Patel DG,Knittel JJ

更新日期：1996-02-01 00:00:00

abstract：:Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]i) were monitored optically in hair cells mechanically isolated from frog semicircular canals using the membrane-impermeant form of the Ca(2+)-selective dye Oregon Green 488 BAPTA-1 (OG, 100 microM). Cells stimulated by depolarization under whole-cell voltage cla...

journal_title：Cell calcium

authors： Rispoli G,Martini M,Rossi ML,Mammano F

更新日期：2001-08-01 00:00:00

abstract：:The concentration of free Ca2+ in the cytoplasm and organelles of individual mouse pancreatic beta-cells was estimated with dual wavelength microfluorometry and the indicators Fura-2 and furaptra. Measuring the increase of cytoplasmic Ca2+ resulting from intracellular mobilization of the ion in ob/ob mouse beta-cells,...

journal_title：Cell calcium

authors： Tengholm A,Hellman B,Gylfe E

更新日期：2000-01-01 00:00:00

abstract：:Cardiac muscle excitation-contraction coupling is controlled by the Ca(2+)-induced Ca2+ release mechanism. The present study examines the effects of a calmodulin antagonist W-7 on Ca2+ current (ICa)-induced Ca2+ release in whole cell-clamped rat ventricular myocytes. Exposure of cells to W-7 suppressed ICa, but the in...

journal_title：Cell calcium

authors： Suzuki YJ,Wang W,Morad M

更新日期：1999-03-01 00:00:00

abstract：:The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we di...

journal_title：Cell calcium

authors： Rorsman P,Braun M,Zhang Q

更新日期：2012-03-01 00:00:00

abstract：:Ca2+ signalling governs stimulated exocytosis and exocytosis-coupled endocytosis also in Paramecium cells. Upon stimulation, the < or =10(3) dense-core exocytotic organelles (trichocysts) can be synchronously (80 ms) released, followed by endocytotic membrane resealing (350 ms) and retrieval. Paramecium is the most sy...

journal_title：Cell calcium

authors： Plattner H,Kissmehl R

更新日期：2005-09-01 00:00:00

abstract：:Extracellular nucleotides are potent Ca2+ mobilizing agents. A variety of receptors for extracellular ATP are recognised. Some are involved in fast neuronal transmission and operate as ligand-gated ion channels. Others are involved in the paracrine or autocrine modulation of cell function. Many receptors of this type ...

journal_title：Cell calcium

authors： Conigrave AD,Jiang L

更新日期：1995-02-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...

journal_title：Cell calcium

authors： Shin HS

更新日期：2006-08-01 00:00:00

abstract：:The L-type Ca2+ channel (Ca(v)1.2) is the main pathway for trans-sarcolemmal (SL) Ca2+ influx in cardiac myocytes. To maintain Ca2+ homeostasis, chronic SL Ca(2+)-influx must be matched by chronic SL efflux. In this study we tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We ...

journal_title：Cell calcium

authors： Lester WC,Schroder EA,Burgess DE,Yozwiak D,Andres DA,Satin J

更新日期：2008-10-01 00:00:00

abstract：:Several recent reports have demonstrated how engineered proteins can control cell motility, an important functional module for ultimately programming cells as therapeutics. We have reported two engineered proteins that regulate the blebbing cell morphology using chimeras of RhoA, a protein that regulates cytoskeletal ...

journal_title：Cell calcium

authors： Mills E,Truong K

更新日期：2013-03-01 00:00:00

abstract：:An initial model has been proposed to describe a mechanism for cytosolic calcium oscillations [Jafri MS. Vajda S. Pasik P. Gillo B. (1992) A membrane model for cytosolic calcium oscillations: a study using Xenopus oocytes. Biophys. J., 63, 235-246]. In this paper we extend our original model to include the effects of ...

journal_title：Cell calcium

authors： Jafri MS,Gillo B

更新日期：1994-07-01 00:00:00

abstract：:Three decades ago, James W. Putney Jr. conceptualized the idea of store-operated calcium entry (SOCE) to explain how depletion of endoplasmic reticulum (ER) Ca2+ stores evokes Ca2+ influx across the plasma membrane. Since the publication of this highly influential idea, it is now established that SOCE is universal amo...

journal_title：Cell calcium

authors： Yeung PS,Yamashita M,Prakriya M

更新日期：2017-05-01 00:00:00

abstract：:In previous works, we have shown that L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors (NMDAr), neuronal nitric oxide synthase (nNOS) and cytochrome b5 reductase (Cb5R) co-localize within the same lipid rafts-associated nanodomains in mature cerebellar granule neurons (CGN). In this work, we sh...

journal_title：Cell calcium

authors： Marques-da-Silva D,Gutierrez-Merino C

更新日期：2014-08-01 00:00:00

abstract：:Calcium and redox signals are presently established as essential regulators of many cellular processes. Nevertheless, we are still far from fully understanding the physiological and pathological importance of these universal second messengers. It is becoming increasingly apparent that many cellular functions are not r...

journal_title：Cell calcium

authors： Gibhardt CS,Zimmermann KM,Zhang X,Belousov VV,Bogeski I

更新日期：2016-08-01 00:00:00

abstract：:Factors contributing to "local control" of Ca2+ release in cardiac myocytes are incompletely understood. We induced local release of Ca2+ by regional exposure of mouse atrial and ventricular myocytes to 10mM caffeine for 500 ms using a rapid solution switcher. Propagation of Ca2+ release was imaged by means of a Nipko...

journal_title：Cell calcium

authors： Seguchi H,Ritter M,Shizukuishi M,Ishida H,Chokoh G,Nakazawa H,Spitzer KW,Barry WH

更新日期：2005-07-01 00:00:00

abstract：:Recent developments in microscopy and fluorescent indicators now make it possible to monitor the activity and localization of membrane ion channels by imaging Ca(2+) flux through individual channels. Such optical approaches have advantages over electrophysiological single-channel techniques in that they are less invas...

journal_title：Cell calcium

authors： Shuai J,Parker I

更新日期：2005-04-01 00:00:00

abstract：:The actions of the novel calcium (Ca2+) channel antagonist mibefradil (Ro 40-5967), a selective T-type channel blocker in myocardium, were investigated in embryonic rat spinal motoneurones maintained in culture. Whole-cell currents were recorded with the patch-clamp technique. Motoneurones displayed transient, low-vol...

journal_title：Cell calcium

authors： Viana F,Van den Bosch L,Missiaen L,Vandenberghe W,Droogmans G,Nilius B,Robberecht W

更新日期：1997-10-01 00:00:00

abstract：:Peripheral astrocytic processes (PAPs) are highly motile structures that are strategically positioned in close proximity to synapses. Long-lasting PAP retraction in hypothalamus is known to alter synaptic transmission. The PAP motility is likely to be actin-based because they are known to contain actin-related protein...

journal_title：Cell calcium

authors： Molotkov D,Zobova S,Arcas JM,Khiroug L

更新日期：2013-05-01 00:00:00

abstract：:Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually ...

journal_title：Cell calcium

authors： Baines CP,Gutiérrez-Aguilar M

更新日期：2018-07-01 00:00:00

abstract：:Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na(+)-Ca2+ exchanger (NCX1) to correlate suppression of the Na(+)-Ca2+ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both...

journal_title：Cell calcium

authors： Egger M,Porzig H,Niggli E,Schwaller B

更新日期：2005-03-01 00:00:00

abstract：:Rabbit gall-bladder epithelial cells were isolated by a combination of Ca2+ omission, enzymatic treatment, and mechanical detachment and had a viability of 96-98% and well preserved morphology. Measurements of cytosolic free Ca2+ concentration ([Ca2+]i) in these cells with the Ca2+-fluorescent indicator fura-2 demonst...

journal_title：Cell calcium

authors： Bouchelouche PN,Hainau B,Frederiksen O

更新日期：1989-01-01 00:00:00

abstract：:Numerous lines of evidence indicate that nuclear calcium concentration ([Ca2+]n) may be controlled independently from cytosolic events by a local machinery. In particular, the perinuclear space between the inner nuclear membrane (INM) and the outer nuclear membrane (ONM) of the nuclear envelope (NE) likely serves as a...

journal_title：Cell calcium

authors： Secondo A,Petrozziello T,Tedeschi V,Boscia F,Pannaccione A,Molinaro P,Annunziato L

更新日期：2020-03-01 00:00:00

abstract：:The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...

journal_title：Cell calcium

authors： Tse A,Lee AK,Tse FW

更新日期：2012-03-01 00:00:00

abstract：:Rapid formation of high-Ca2+ perimitochondrial cytoplasmic microdomains has been shown to evoke mitochondrial Ca2+ signal and activate mitochondrial dehydrogenases, however, the significance of submicromolar cytoplasmic Ca2+ concentrations in the control of mitochondrial metabolism has not been sufficiently elucidated...

journal_title：Cell calcium

authors： Pitter JG,Maechler P,Wollheim CB,Spät A

更新日期：2002-02-01 00:00:00