Calcium signaling and epigenetics: A key point to understand carcinogenesis.

abstract：:Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...

journal_title：Cell calcium

authors： Texidó L,Martín-Satué M,Alberdi E,Solsona C,Matute C

更新日期：2011-03-01 00:00:00

abstract：:We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit ...

journal_title：Cell calcium

authors： Molski TF,Naccache PH,Sha'afi RI

更新日期：1983-02-01 00:00:00

abstract：:A synthetic peptide (CaMBP) matching amino acids 3614-3643 of the skeletal ryanodine receptor (RyR1) binds to both Ca2+-free calmodulin (CaM) and Ca2+-bound CaM with nanomolar affinity [J. Biol. Chem. 276 (2001) 2069]. We report here that CaMBP increases [3H]ryanodine binding to RyR1 in a dose- and Ca2+-dependent mann...

journal_title：Cell calcium

authors： Zhu X,Ghanta J,Walker JW,Allen PD,Valdivia HH

更新日期：2004-02-01 00:00:00

abstract：:The importance of Ca2+-signaling for many subcellular processes is well established in higher eukaryotes, whereas information about protozoa is restricted. Recent genome analyses have stimulated such work also with Alveolates, such as ciliates (Paramecium, Tetrahymena) and their pathogenic close relatives, the Apicomp...

journal_title：Cell calcium

authors： Plattner H,Sehring IM,Mohamed IK,Miranda K,De Souza W,Billington R,Genazzani A,Ladenburger EM

更新日期：2012-05-01 00:00:00

abstract：:The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...

journal_title：Cell calcium

authors： Tse A,Lee AK,Tse FW

更新日期：2012-03-01 00:00:00

abstract：:Indo-1 is a new fluorescent indicator of the intracellular free calcium concentration Cai++. Indo-1 may be used in a similar manner as its predecessor quin2 but offers the principal advantage that the Ca++ saturated form of the Ca++ chelator has a emission maximum different in wavelength from that of free indo-1 (400 ...

journal_title：Cell calcium

authors： Lückhoff A

更新日期：1986-08-01 00:00:00

abstract：:The annexins are a family of calcium-binding proteins. Data from protein and cDNA sequencing have shown that at least five distinct but closely related mammalian annexins exist each of which possesses four or eight homologous internal repeats which may be calcium-and phospholipid-binding domains. The proteins are pres...

journal_title：Cell calcium

authors： Burgoyne RD,Geisow MJ

更新日期：1989-01-01 00:00:00

abstract：:MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca2+) release. Systolic blood pressure (SBP) and vasoreactivity to VSMC con...

journal_title：Cell calcium

authors： Gabani M,Liu J,Ait-Aissa K,Koval O,Kim YR,Castañeda D,Vikram A,Jacobs JS,Grumbach I,Trebak M,Irani K,Kassan M

更新日期：2019-06-01 00:00:00

abstract：:Near-membrane [Ca2+] may differ significantly from bulk cytosolic [Ca2+], particularly during rapid Ca2+ signalling events related to cardiac muscle excitation-contraction coupling. We used the lipophilic membrane-associated Ca2+ indicator Ca(2+)-Green C-18 (C-18) and laser-scanning confocal microscopy to detect extra...

journal_title：Cell calcium

authors： Blatter LA,Niggli E

更新日期：1998-05-01 00:00:00

abstract：:Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNA...

journal_title：Cell calcium

authors： Misquitta CM,Chen T,Grover AK

更新日期：2006-10-01 00:00:00

abstract：:Although store-operated calcium entry (SOCE) was identified more that two decades ago, understanding the molecular mechanisms that regulate and mediate this process continue to pose a major challenge to investigators in this field. Thus, there has been major focus on determining which of the models proposed for this m...

journal_title：Cell calcium

authors： Ambudkar IS,Ong HL,Liu X,Bandyopadhyay BC,Cheng KT

更新日期：2007-08-01 00:00:00

abstract：:Many fluorescent Ca indicators, particularly those loaded as acetoxymethyl (AM)-ester derivatives, are known to become compartmentalized into organelles. This property can be exploited to measure changes in free [Ca] in subcellular compartments, including the inositol (1,4,5)-trisphosphate-sensitive store. However, qu...

journal_title：Cell calcium

authors： Hofer AM,Schulz I

更新日期：1996-09-01 00:00:00

abstract：:Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...

journal_title：Cell calcium

authors： Medic N,Desai A,Olivera A,Abramowitz J,Birnbaumer L,Beaven MA,Gilfillan AM,Metcalfe DD

更新日期：2013-05-01 00:00:00

abstract：:Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X...

journal_title：Cell calcium

authors： Ceruti S,Fumagalli M,Villa G,Verderio C,Abbracchio MP

更新日期：2008-06-01 00:00:00

abstract：:We describe experiments in which the low affinity indicator Oregon Green BAPTA 5N was used to record the spatially resolved changes in [Ca(2+)] from intracellular stores in rat gastric myocytes. Cells were loaded with the membrane permeant form of the indicator and imaged using a confocal scanning laser microscope. In...

journal_title：Cell calcium

authors： White C,McGeown G

更新日期：2002-04-01 00:00:00

abstract：:The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling oper...

journal_title：Cell calcium

authors： Ahuja M,Jha A,Maléth J,Park S,Muallem S

更新日期：2014-06-01 00:00:00

abstract：:The actions of the novel calcium (Ca2+) channel antagonist mibefradil (Ro 40-5967), a selective T-type channel blocker in myocardium, were investigated in embryonic rat spinal motoneurones maintained in culture. Whole-cell currents were recorded with the patch-clamp technique. Motoneurones displayed transient, low-vol...

journal_title：Cell calcium

authors： Viana F,Van den Bosch L,Missiaen L,Vandenberghe W,Droogmans G,Nilius B,Robberecht W

更新日期：1997-10-01 00:00:00

abstract：:We tested a mixture of Calcium-Green-1 (CG-1) and Brilliantsulfaflavine (BS) for dual excitation ratiometric measurements of the intracellular free calcium concentration ([Ca2+]i) in bovine adrenal chromaffin cells. Dyes were coloaded (without being molecularly linked to each other) in the whole-cell configuration of ...

journal_title：Cell calcium

authors： Oheim M,Naraghi M,Müller TH,Neher E

更新日期：1998-07-01 00:00:00

abstract：:Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na(+)-Ca2+ exchanger (NCX1) to correlate suppression of the Na(+)-Ca2+ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both...

journal_title：Cell calcium

authors： Egger M,Porzig H,Niggli E,Schwaller B

更新日期：2005-03-01 00:00:00

abstract：:Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and envir...

journal_title：Cell calcium

authors： Medic N,Desai A,Komarow H,Burch LH,Bandara G,Beaven MA,Metcalfe DD,Gilfillan AM

更新日期：2011-11-01 00:00:00

abstract：:In HEK293 cells, transfected with the Ca2+ channel protein TRPV6, Ca2+ influx is increased and TRPV6 is tyrosine phosphorylated following addition of the tyrosine phosphatase inhibitor N,N-dimethyl-hydroxamido hydroxovanadate to cells. This effect of DMHV is enhanced by co-transfection of cells with the tyrosine kinas...

journal_title：Cell calcium

authors： Sternfeld L,Anderie I,Schmid A,Al-Shaldi H,Krause E,Magg T,Schreiner D,Hofer HW,Schulz I

更新日期：2007-07-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:We present a new method for ratiometric Ca2+ measurements using indicators with excitation spectra in the visible range of wavelengths. Laser-scanning confocal microscopy was used to record intracellular Ca(2+)-signals with high temporal and spatial resolution in single cardiac myocytes. The patch-clamp technique was ...

journal_title：Cell calcium

authors： Lipp P,Niggli E

更新日期：1993-05-01 00:00:00

abstract：:While genetically encoded Ca(2+) indicators (GECIs) allow Ca(2+) imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the inte...

journal_title：Cell calcium

authors： Wong SS,Kotera I,Mills E,Suzuki H,Truong K

更新日期：2012-01-01 00:00:00

abstract：:Calcium and calcium-dependent systems have been long implicated in the induction of epilepsy. We have previously observed that intracellular calcium ([Ca2+]i) levels remain elevated in cells undergoing epileptogenesis in the hippocampal neuronal culture (HNC) model. In this study, we employed the hippocampal neuronal ...

journal_title：Cell calcium

authors： Pal S,Limbrick DD Jr,Rafiq A,DeLorenzo RJ

更新日期：2000-09-01 00:00:00

abstract：:The lungs as the gateways of our body to the external environment are essential for gas exchange. They are also exposed to toxicants from two sides, the airways and the vasculature. Apart from naturally produced toxic agents, millions of human made chemicals were produced since the beginning of the industrial revoluti...

journal_title：Cell calcium

authors： Dietrich A,Steinritz D,Gudermann T

更新日期：2017-11-01 00:00:00

abstract：:Hard end is a physiological disorder of pear fruit that is frequently observed in the 'Whangkeumbae' (Pyrus pyrifolia) variety, however, the mechanisms that are involved in its development are poorly understood. In this study, we explored the causes of hard end disorder in pear fruit in relation to calcium deficiency....

journal_title：Cell calcium

authors： Wang Y,Zhang X,Wang Y,Yang S,Qu H

更新日期：2018-05-01 00:00:00

abstract：:Fluorescence imaging of calcium ions (Ca(2+)) has become an essential technique for investigation of signaling pathways involving Ca(2+) as a second messenger. But, Ca(2+) signaling is involved in many biological phenomena, and therefore simultaneous visualization of Ca(2+) and other biomolecules (multicolor imaging) ...

journal_title：Cell calcium

authors： Hirabayashi K,Hanaoka K,Egawa T,Kobayashi C,Takahashi S,Komatsu T,Ueno T,Terai T,Ikegaya Y,Nagano T,Urano Y

更新日期：2016-10-01 00:00:00

abstract：:Receptor-activated cytoplasmic calcium (Ca2+) oscillations have been investigated in single pancreatic acinar cells by microfluorimetry (Fura-2 as indicator). At submaximal concentrations of the agonists acetylcholine (ACh) and cholecystokinin octapeptide (CCK-8), both give rise to oscillatory changes in the cytosolic...

journal_title：Cell calcium

authors： Yule DI,Lawrie AM,Gallacher DV

更新日期：1991-02-01 00:00:00

abstract：:We have used single cell fluorescence imaging techniques to examine how functional properties of the caffeine-sensitive Ca(2+) store change during differentiation of a sub-population of caffeine-sensitive SH-SY5Y cells. Application of caffeine (30 mM) 1-10.5 min after a 'priming' depolarisation pulse of 55 mM K(+) rev...

journal_title：Cell calcium

authors： Riddoch FC,Brown AM,Rowbotham SE,Redfern CP,Cheek TR

更新日期：2007-03-01 00:00:00