Abstract:
:Pancreatitis is an increasingly common disease that carries a significant mortality and which lacks specific therapy. Pathological calcium signalling is an important contributor to the initiating cell injury, caused by or acting through mitochondrial inhibition. A principal effect of disordered cell signalling and impaired mitochondrial function is cell death, either by apoptosis that is primarily protective, or by necrosis that is deleterious, both locally and systemically. Mitochondrial calcium overload is particularly important in necrotic injury, which may include damage mediated by the mitochondrial permeability transition pore. The role of reactive oxygen species remains controversial. Present understanding of the part played by disordered pancreatic acinar calcium signalling and mitochondrial inhibition offers several new potential therapeutic targets.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Mukherjee R,Criddle DN,Gukovskaya A,Pandol S,Petersen OH,Sutton Rdoi
10.1016/j.ceca.2007.11.013subject
Has Abstractpub_date
2008-07-01 00:00:00pages
14-23issue
1eissn
0143-4160issn
1532-1991pii
S0143-4160(07)00184-4journal_volume
44pub_type
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