Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.

abstract：:Studies were conducted using normal and human papillomavirus Type 18 (HPV-18) immortalized human keratinocytes to assess possible alterations in the differentiation process as a consequence of increased intracellular calcium concentration. Normal keratinocytes exposed to increased extracellular calcium or the phorbol ...

journal_title：Cell calcium

authors： Garrett LR,Coder DM,McDougall JK

更新日期：1991-05-01 00:00:00

abstract：:Removal of the epithelium from preparations of guinea-pig airways in vitro increases the responsiveness of the smooth muscle of normal and ovalbumin-sensitized animals to a number of contractile agents. To determine if epithelium removal results in an increase in Ca2+ entry into the smooth muscle, the effect of removi...

journal_title：Cell calcium

authors： Raeburn D,Hay DW,Fedan JS

更新日期：1987-12-01 00:00:00

abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...

journal_title：Cell calcium

authors： Shin HS

更新日期：2006-08-01 00:00:00

abstract：:The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In ...

journal_title：Cell calcium

authors： Eilers J,Plant T,Konnerth A

更新日期：1996-08-01 00:00:00

abstract：:Membrane deformation induced by a mechanical stimulus increases the [Ca2+]i in cultured retinal pigment epithelial (RPE) cells, and in many other cell types. In this study, confocal microscopy and Ca(2+)-measurements using the fluorescent dye fluo-3 were used to measure the spatiotemporal characteristics of the Ca(2+)...

journal_title：Cell calcium

authors： Stalmans P,Himpens B

更新日期：1999-06-01 00:00:00

abstract：:Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...

journal_title：Cell calcium

authors： Medic N,Desai A,Olivera A,Abramowitz J,Birnbaumer L,Beaven MA,Gilfillan AM,Metcalfe DD

更新日期：2013-05-01 00:00:00

abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...

journal_title：Cell calcium

authors： Ong HL,Ambudkar IS

更新日期：2015-10-01 00:00:00

abstract：:Signaling between intracellular Ca2+ stores and cell membrane channels or transporters is important to Ca(2+)-based second messenger systems. Two hypotheses, the capacitative and the Ca(2+)-induced Ca(2+)-influx models have been proposed to explain aspects of this signaling. In this study, we examined the applicabilit...

journal_title：Cell calcium

authors： Razani-Boroujerdi S,Partridge LD,Sopori ML

更新日期：1994-12-01 00:00:00

abstract：:Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly...

journal_title：Cell calcium

authors： De Jonge HW,Atsma DE,van der Valk-Kokshoorn EJ,van Heugten HA,van der Laarse A,Lamers JM

更新日期：1995-12-01 00:00:00

abstract：:C3H/10T1/2 mouse embryo fibroblasts stimulated by a steady electric field (10 V/cm) for 30 min exhibited lamellar retraction on the sides facing the electrodes. Some cells elongated and preferentially oriented with their long axis perpendicular to the field direction. Depletion of external calcium or blockage of calci...

journal_title：Cell calcium

authors： Onuma EK,Hui SW

更新日期：1985-06-01 00:00:00

abstract：:This investigation concentrates on the change in Ca(2+) concentration ([Ca(2+)]) caused by ryanodine in U373 MG cells. This cell type from a human astrocytoma is a unique cellular model because it only expresses the type 3 ryanodine receptor (RyR3), which is generally the least abundant isoform. In the presence of phy...

journal_title：Cell calcium

authors： Galiano M,Gasparre G,Lippe C,Cassano G

更新日期：2004-11-01 00:00:00

abstract：:The regulation of intracellular Ca(2+) signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine phosphorylation. Evidence from non-excitable cells implicates tyrosine phosphorylation in the activation of so-called store-operated Ca(2+) channels (SOCCs), but their involvemen...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Platt B

更新日期：2009-07-01 00:00:00

abstract：:TRP family of proteins are components of unique cation channels that are activated in response to diverse stimuli ranging from growth factor and neurotransmitter stimulation of plasma membrane receptors to a variety of chemical and sensory signals. This review will focus on members of the TRPC sub-family (TRPC1-TRPC7)...

journal_title：Cell calcium

authors： Ambudkar IS,Bandyopadhyay BC,Liu X,Lockwich TP,Paria B,Ong HL

更新日期：2006-11-01 00:00:00

abstract：:T-type Ca(2+) channel family includes three subunits Ca(V)3.1, Ca(V)3.2 and Ca(V)3.3 and have been shown to control burst firing and intracellular Ca(2+) concentration ([Ca(2+)](i)) in neurons. Here, we investigated whether Ca(V)3.1 channels could generate a pacemaker current and contribute to cell excitability. Ca(V)...

journal_title：Cell calcium

authors： Chevalier M,Mironneau C,Macrez N,Quignard JF

更新日期：2008-12-01 00:00:00

abstract：:Mammalian homologues of the Drosophila transient receptor potential channel (TRPC) are involved in Ca(2+) entry following agonist stimulation of nonexcitable cells. Seven mammalian TRPCs have been cloned but their mechanisms of activation and/or regulation are still the subject of intense research efforts. It has alre...

journal_title：Cell calcium

authors： Boulay G

更新日期：2002-10-01 00:00:00

abstract：:When Xenopus oocytes injected with rat brain poly(A)+RNA were voltage-clamped in a recording solution containing Ca2+, a depolarization pulse induced a transient current, ICl(Ca), which reflects calmodulin-mediated opening of endogenous Cl- channels in response to a Ca2+ influx through Ca2+ channels of brain origin. I...

journal_title：Cell calcium

authors： Kaneko S,Doi E,Watanabe H,Nomura Y

更新日期：1990-04-01 00:00:00

abstract：:We report here the first local and global Ca(2+) measurements made from in situ terminal arterioles. The advantages of the method are that there is minimal disturbance to the vessels, which retain their relationship to the tissue they are supplying (rat ureter) and the small size of vessel that can be studied. Good lo...

journal_title：Cell calcium

authors： Burdyga T,Shmygol A,Eisner DA,Wray S

更新日期：2003-07-01 00:00:00

abstract：:The tissue/medium distribution of the nonmetabolized glucose analog [14C]-3-O-methyl-D-glucose was measured in pigeon erythrocytes and related to changes in 45Ca uptake and efflux, total calcium content and ATP levels. Sugar transport was not affected by changes in external Ca2+. However, both sugar and 45Ca influx we...

journal_title：Cell calcium

authors： Bihler I,Charles P,Sawh PC

更新日期：1982-08-01 00:00:00

abstract：:Vesl/Homer proteins physically link proteins that mediate cellular signaling [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851] and thereby influence cellular function [Nat. Neurosci. 4 (2001) 499; Nature 411 (2001) 962]. A previous study reported that Vesl-1L/Homer-1c ...

journal_title：Cell calcium

authors： Hwang SY,Wei J,Westhoff JH,Duncan RS,Ozawa F,Volpe P,Inokuchi K,Koulen P

更新日期：2003-08-01 00:00:00

abstract：:We have previously demonstrated a role for the reorganization of the actin cytoskeleton in store-operated calcium entry (SOCE) in human platelets and interpreted this as evidence for a de novo conformational coupling step in SOCE activation involving the type II IP(3) receptor and the platelet hTRPC1-containing store-...

journal_title：Cell calcium

authors： Harper AG,Sage SO

更新日期：2007-12-01 00:00:00

abstract：:The formation of a heterotetrameric complex between annexin 2 (anx 2) and S100A10 plays an important role in regulating the cellular distribution and biochemical properties of anx 2. A major distinction between the anx 2-S100A10 complex and other annexin-S100 complexes is that S100A10 binding to anx 2 occurs independe...

journal_title：Cell calcium

authors： Borthwick LA,Neal A,Hobson L,Gerke V,Robson L,Muimo R

更新日期：2008-08-01 00:00:00

abstract：:While genetically encoded Ca(2+) indicators (GECIs) allow Ca(2+) imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the inte...

journal_title：Cell calcium

authors： Wong SS,Kotera I,Mills E,Suzuki H,Truong K

更新日期：2012-01-01 00:00:00

abstract：:Ca2+ efflux from dog red blood cells loaded with Ca2+ using the A23187 ionophore could be separated into two main components: (1) Mg- and ATP-dependent (active transport) and (2) dependent on external Na (K1/2 around 15 mM); at 80 microM internal free Ca the relative magnitudes of these fluxes were 70% and 30% respect...

journal_title：Cell calcium

authors： Altamirano AA,Beaugé L

更新日期：1985-12-01 00:00:00

abstract：:Several recent reports have demonstrated how engineered proteins can control cell motility, an important functional module for ultimately programming cells as therapeutics. We have reported two engineered proteins that regulate the blebbing cell morphology using chimeras of RhoA, a protein that regulates cytoskeletal ...

journal_title：Cell calcium

authors： Mills E,Truong K

更新日期：2013-03-01 00:00:00

abstract：:The effect of the uterotonic pituitary hormone oxytocin on the regulation of intracellular calcium concentration ([Ca2+]i) was studied in single cells of a smooth muscle cell line derived from human non-pregnant myometrium. [Ca2+]i was measured with fluorescence microscopy, and by recording the activity of Ca(2+)-acti...

journal_title：Cell calcium

authors： Holda JR,Oberti C,Perez-Reyes E,Blatter LA

更新日期：1996-07-01 00:00:00

abstract：:Rat liver was homogenized and subjected to differential centrifugation. When the low speed nuclear pellet was processed on a Percoll gradient, plasma membrane markers and Ins(1,4,5)P3 binding activity purified together. The high speed (microsomal) fraction was subfractionated by sucrose density gradient centrifugation...

journal_title：Cell calcium

authors： Enyedi P,Szabadkai G,Krause KH,Lew DP,Spät A

更新日期：1993-06-01 00:00:00

abstract：:Both theoretical and experimental results are presented for in vivo calibration of the dissociation constant K(Ca)(d)of the calcium-sensitive fluorescent dye Rhod(2)in the perfused mouse heart, using manganese quenching of fluorescence transients. An analytical model is derived, based on the biochemical equilibrium of...

journal_title：Cell calcium

authors： Du C,MacGowan GA,Farkas DL,Koretsky AP

更新日期：2001-04-01 00:00:00

abstract：:Odontoblasts are involved in the transduction of stimuli applied to exposed dentin. Although expression of thermo/mechano/osmo-sensitive transient receptor potential (TRP) channels has been demonstrated, the properties of TRP vanilloid 1 (TRPV1)-mediated signaling remain to be clarified. We investigated physiological ...

journal_title：Cell calcium

authors： Tsumura M,Sobhan U,Muramatsu T,Sato M,Ichikawa H,Sahara Y,Tazaki M,Shibukawa Y

更新日期：2012-08-01 00:00:00

abstract：:In previous studies we have characterised various properties of capacitative Ca2+ entry (CCE) in different epithelia. After Ca2+ store depletion with PLC/InsP3-coupled agonists or by inhibition of store Ca2+ uptake, with for example thapsigargin, Ca2+ influx is activated. This leads to a sustained cellular response (e...

journal_title：Cell calcium

authors： Gordjani N,Nitschke R,Greger R,Leipziger J

更新日期：1997-08-01 00:00:00

abstract：:Localized subcellular changes in Ca(2+) serve as important cellular signaling elements, regulating processes as diverse as neuronal excitability and gene expression. Studies of cellular Ca(2+) signaling have been greatly facilitated by the availability of fluorescent Ca(2+) indicators. The respective merits of differe...

journal_title：Cell calcium

authors： Lock JT,Parker I,Smith IF

更新日期：2015-12-01 00:00:00