Abstract：
:Specific Ca(2+) homeostatic system appeared very early in the history of the cell, as a survival system preventing Ca(2+)-mediated cell damage. This homeostatic system produced a steep ( approximately 20,000 times) concentration gradient between extracellular and intracellular compartments, which has both survival importance (even relatively short increases in cytosolic Ca(2+) concentrations higher then 100 nM are incompatible with life) and signalling function. Evolution utilised this gradient together with an ability of Ca(2+) to interact with many biological molecules to create the most widespread and versatile signalling system, controlling the majority of cellular processes and executing complex routines of intercellular communications.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Case RM,Eisner D,Gurney A,Jones O,Muallem S,Verkhratsky Adoi
10.1016/j.ceca.2007.05.001subject
Has Abstractpub_date
2007-10-01 00:00:00pages
345-50issue
4-5eissn
0143-4160issn
1532-1991pii
S0143-4160(07)00097-8journal_volume
42pub_type
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