The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor.

abstract：:There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol...

journal_title：Cell calcium

authors： Taggart MJ,Wray S

更新日期：1997-11-01 00:00:00

abstract：:Nanosecond-duration electric stimuli are distinguished by the ability to permeabilize intracellular membranes and recruit Ca2+ from intracellular stores. We quantified this effect in non-excitable cells (CHO) using ratiometric Ca2+ imaging with Fura-2. In a Ca(2+)-free medium, 10-, 60-, and 300-ns stimuli evoked Ca2+ ...

journal_title：Cell calcium

authors： Semenov I,Xiao S,Pakhomova ON,Pakhomov AG

更新日期：2013-09-01 00:00:00

abstract：:The activation of T lymphocytes, like many cells, requires a rapid rise in intracellular Ca2+ secondary to both an influx and a release from intracellular stores. The latter is activated by inositol-1,4,5-trisphosphate [Ins(1,4,5)P3]. It is controversial if inositol phosphates can also stimulate a plasma membrane Ca2+...

journal_title：Cell calcium

authors： O'Riordan C,Rosoff PM

更新日期：1993-02-01 00:00:00

abstract：:Signaling between intracellular Ca2+ stores and cell membrane channels or transporters is important to Ca(2+)-based second messenger systems. Two hypotheses, the capacitative and the Ca(2+)-induced Ca(2+)-influx models have been proposed to explain aspects of this signaling. In this study, we examined the applicabilit...

journal_title：Cell calcium

authors： Razani-Boroujerdi S,Partridge LD,Sopori ML

更新日期：1994-12-01 00:00:00

abstract：:Pituitary neuropeptide oxytocin is increasingly recognised as a cardiovascular hormone, in addition to its many regulatory roles in other organ systems. Studies in atrial and ventricular myocytes from the neonatal and adult rats have identified synthesis of oxytocin and the expression of oxytocin receptors in these ce...

journal_title：Cell calcium

authors： Ali II,Al-Salam S,Howarth FC,Shmygol A

更新日期：2019-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the molecular mechanisms whereby these mutations induce motor neuron death remain controversial. Here, we show that stable overex...

journal_title：Cell calcium

authors： Coussee E,De Smet P,Bogaert E,Elens I,Van Damme P,Willems P,Koopman W,Van Den Bosch L,Callewaert G

更新日期：2011-04-01 00:00:00

abstract：:N,N'-dicyclohexylcarbodiimide (DCCD) and 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide (CMCD) inhibited calmodulin-dependent Ca2(+)+Mg2(+)-ATPase activity in erythrocyte ghost membranes. The extent of the inhibition caused by carbodiimides strongly depended on their hydrophobicity. Hydrophobic DCCD was a more potent...

journal_title：Cell calcium

authors： Famulski KS,Pikula S,Wrzosek A,Wojtczak AB

更新日期：1990-04-01 00:00:00

abstract：:Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...

journal_title：Cell calcium

authors： Texidó L,Martín-Satué M,Alberdi E,Solsona C,Matute C

更新日期：2011-03-01 00:00:00

abstract：:Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]i) were monitored optically in hair cells mechanically isolated from frog semicircular canals using the membrane-impermeant form of the Ca(2+)-selective dye Oregon Green 488 BAPTA-1 (OG, 100 microM). Cells stimulated by depolarization under whole-cell voltage cla...

journal_title：Cell calcium

authors： Rispoli G,Martini M,Rossi ML,Mammano F

更新日期：2001-08-01 00:00:00

abstract：:Cyclic AMP regulates the late step of Ca²+-dependent exocytosis in many secretory cells through two major mechanisms: a protein kinase A-dependent and a cAMP-GEF/Epac-dependent pathway. We designed a protocol to characterize the role of these two cAMP-dependent pathways on the Ca²+ sensitivity and kinetics of regulate...

journal_title：Cell calcium

authors： Skelin M,Rupnik M

更新日期：2011-02-01 00:00:00

abstract：:Calcium-permeable channels have traditionally been thought of as therapeutic targets in excitable cells. For instance, voltage-operated Ca2+ channels in neurones and smooth muscle cells for neurological and cardiovascular diseases although calcium-permeable channels are also functionally important in electrically non-...

journal_title：Cell calcium

authors： Li S,Westwick J,Poll C

更新日期：2003-05-01 00:00:00

abstract：:Inhibition by Mg2+ ions of exocytotic secretion from permeabilised eosinophils, stimulated by Ca2+ and GTP gamma S, and in the presence and absence of ATP, has been examined. While Mg2+ inhibits release of aryl sulphatase, hexosaminidase and peroxidase, we found no evidence that this occurs by competition at a Ca(2+)-...

journal_title：Cell calcium

authors： Larbi KY,Gomperts BD

更新日期：1997-03-01 00:00:00

abstract：:We have recently shown that freshly isolated astrocytes from the mouse brain express mRNA for the L-channel gene Cav1.3 to at least the same degree (per mg mRNA) as corresponding neurons. The amount of extracellular Ca(2+) actually entering cultured astrocytes by its opening is modest, but due to secondary Ca(2+)-medi...

journal_title：Cell calcium

authors： Du T,Liang C,Li B,Hertz L,Peng L

更新日期：2014-03-01 00:00:00

abstract：:A variety of stimuli utilize an increase of cytosolic free Ca(2+) concentration as a second messenger to transmit signals, through Ca(2+) release from the endoplasmic reticulum or opening of plasma membrane Ca(2+) channels. Mitochondria contribute to the tight spatiotemporal control of this process by accumulating Ca(...

journal_title：Cell calcium

authors： Rasola A,Bernardi P

更新日期：2011-09-01 00:00:00

abstract：:Calcium and calcium-dependent systems have been long implicated in the induction of epilepsy. We have previously observed that intracellular calcium ([Ca2+]i) levels remain elevated in cells undergoing epileptogenesis in the hippocampal neuronal culture (HNC) model. In this study, we employed the hippocampal neuronal ...

journal_title：Cell calcium

authors： Pal S,Limbrick DD Jr,Rafiq A,DeLorenzo RJ

更新日期：2000-09-01 00:00:00

abstract：:An enzymatically active Ca2+-stimulated ATPase has been isolated from the sarcolemmal sheets of human smooth muscle (myometrium). Ca2+-ATPase activity was quantitated in an assay medium which simulated the characteristic free ionic concentrations of the cytosol. New computer programs for calculating the composition of...

journal_title：Cell calcium

authors： Popescu LM,Ignat P

更新日期：1983-10-01 00:00:00

abstract：:Light-sensitive channels encoded by the Drosophila transient receptor potential-like gene (trpl) are activated in situ by an unknown mechanism requiring activation of Gq and phospholipase C (PLC). Recent studies have variously concluded that heterologously expressed TRPL channels are activated by direct Gq-protein int...

journal_title：Cell calcium

authors： Hardie RC,Raghu P

更新日期：1998-09-01 00:00:00

abstract：:Cellular redox status is maintained by the balance between series of antioxidant systems and production of reactive oxygen/nitrogenous species. Cells utilize this redox balance to mediate diverse physiological functions. Transient receptor potential (TRP) channels are non-selective cation channels that act as biosenso...

journal_title：Cell calcium

authors： Ogawa N,Kurokawa T,Mori Y

更新日期：2016-08-01 00:00:00

abstract：:Mitochondrial Ca(2+) activates many processes, from mitochondrial metabolism to opening of the permeability transition pore (PTP) and apoptosis. However, there is considerable controversy regarding the free mitochondrial [Ca(2+)] ([Ca(2+)](M)) levels that can be attained during cell activation or even in mitochondrial...

journal_title：Cell calcium

authors： Vay L,Hernández-SanMiguel E,Lobatón CD,Moreno A,Montero M,Alvarez J

更新日期：2009-03-01 00:00:00

abstract：:The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...

journal_title：Cell calcium

authors： Tse A,Lee AK,Tse FW

更新日期：2012-03-01 00:00:00

abstract：:The use of high resolution imaging techniques has revealed new forms of dendritic signal integration in neurones. In contrast to electrical signals that have a more widespread influence on the cell, brief Ca2+ transients resulting from synaptic activation are often restricted to a small part of the dendritic tree. In ...

journal_title：Cell calcium

authors： Eilers J,Plant T,Konnerth A

更新日期：1996-08-01 00:00:00

abstract：:A new method for the determination of tissue concentrations of Fura-2 and Fura-2/AM was developed based upon acetonitrile extraction followed by RP-HPLC separation (using tetrahexylammonium as counter-ion), post-column alkaline hydrolysis of Fura-2/AM, and fluorimetric detection. The detection limit was 1.2 nM and 1 n...

journal_title：Cell calcium

authors： Tran NN,Leroy P,Bellucci L,Robert A,Nicolas A,Atkinson J,Capdeville-Atkinson C

更新日期：1995-11-01 00:00:00

abstract：:The effect of Ca2+ ion concentration on the 25 hydroxylation of tritiated cholecalciferol (3HD3) was investigated using homogenates of ovine liver from vitamin D replete sheep. A significant decrease in the production of 25 hydroxycholecalciferol (25OHD3) was observed when the concentration of Ca2+ in the homogenate w...

journal_title：Cell calcium

authors： Corlett SC,Chaudhary MS,Tomlinson S,Care AD

更新日期：1987-08-01 00:00:00

abstract：:The highly selective fluorescent Ca2+ indicator 'quin 2' has been loaded into ram and boar spermatozoa as the acetoxymethyl ester, 'quin 2/AM', which is hydrolysed and trapped in the cytoplasm. Loadings of several mM were not toxic to spermatozoa as judged by motility. Fluorescence measurements (mean +/- S.E.M.) indic...

journal_title：Cell calcium

authors： Simpson AM,White IG

更新日期：1988-02-01 00:00:00

abstract：:It is well established that intracellular calcium ([Ca2+]i) controls the inotropic state of the myocardium, and evidence mounts that a "Ca2+ clock" controls the chronotropic state of the heart. Recent findings describe a calcium-activated nonselective cation channel (NSCCa) in various cardiac preparations sharing hall...

journal_title：Cell calcium

authors： Burt R,Graves BM,Gao M,Li C,Williams DL,Fregoso SP,Hoover DB,Li Y,Wright GL,Wondergem R

更新日期：2013-09-01 00:00:00

abstract：:TRP family of proteins are components of unique cation channels that are activated in response to diverse stimuli ranging from growth factor and neurotransmitter stimulation of plasma membrane receptors to a variety of chemical and sensory signals. This review will focus on members of the TRPC sub-family (TRPC1-TRPC7)...

journal_title：Cell calcium

authors： Ambudkar IS,Bandyopadhyay BC,Liu X,Lockwich TP,Paria B,Ong HL

更新日期：2006-11-01 00:00:00

abstract：:Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since ...

journal_title：Cell calcium

authors： Izquierdo-Torres E,Hernández-Oliveras A,Fuentes-García G,Zarain-Herzberg Á

更新日期：2020-11-01 00:00:00

abstract：:Several potentially life-threatening cardiovascular and respiratory disorders result in prolonged deprivation of oxygen, which in turn results in significant cellular adaptation, or remodelling. An important component of this functional adaptation arises as a direct consequence of altered ion channel expression by chr...

journal_title：Cell calcium

authors： Peers C,Kemp PJ

更新日期：2004-09-01 00:00:00

abstract：:Infrared neural stimulation (INS) is a promising neurostimulation technique that can activate neural tissue with high spatial precision and without the need for exogenous agents. However, little is understood about how infrared light interacts with neural tissue on a cellular level, particularly within the living brai...

journal_title：Cell calcium

authors： Cayce JM,Bouchard MB,Chernov MM,Chen BR,Grosberg LE,Jansen ED,Hillman EM,Mahadevan-Jansen A

更新日期：2014-04-01 00:00:00

abstract：:CatSper is a sperm-specific Ca(2+) channel that plays an essential role in the male fertility. However, its biophysical properties have been poorly characterized mainly due to its deficient heterologous expression. As other voltage-gated Ca(2+) channels (CaVs), CatSper possesses a conserved Ca(2+)-selective filter mot...

journal_title：Cell calcium

authors： Garza-López E,Chávez JC,Santana-Calvo C,López-González I,Nishigaki T

更新日期：2016-07-01 00:00:00