Abstract：
PURPOSE:Alcoholic liver disease or non-alcoholic fatty liver disease/non-alcoholic steatohepatitis are well-known risk factors for liver fibrosis or cirrhosis and hepatocellular carcinoma; it is a major global health concern, but there are few effective and safe management options. Therefore, we aimed to investigate the effects of fermented garlic extracts (FGEs) on hepatic function in adults with mild hepatic dysfunction without underlying hepatic disease. METHODS:In this double-blind, randomized, placebo-controlled study, seventy-five adults with elevated serum gamma-glutamyl transpeptidase (GGT) levels were included in a FGE-administered group (n = 36) or a placebo group (n = 39), and received either two sachets/day containing FGEs or placebo over a 12-week period. Primary endpoint was the change in serum GGT levels. Data were analysed using a generalized linear mixed effects model. RESULTS:Significant group × time interactions for serum levels of GGT (F = 3.98, P = 0.022) and alanine aminotransferase (ALT; F = 3.28, P = 0.043) were observed with an improvement in levels of GGT (P = 0.066) and ALT (P = 0.014) in the FGE group compared to that reported for the placebo group at the 12-week visits. There was no intergroup difference in the prevalence of adverse events. CONCLUSIONS:Intake of FGEs improved serum GGT and ALT levels in adults with mildly elevated serum GGT level without reported adverse side effects. FGEs might be effective and safe management options for mild hepatic dysfunction.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Kim HN,Kang SG,Roh YK,Choi MK,Song SWdoi
10.1007/s00394-016-1318-6subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1993-2002issue
5eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1318-6journal_volume
56pub_type
杂志文章,随机对照试验abstract：PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1385-3
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1482-3
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Dietary polyphenols have been studied for their potential effects on metabolic disorders, but studies on risk of hypertension are scarce. This study aimed to test the association between total and individual classes of dietary polyphenols and incidence of hypertension in the Polish arm of the Health, Alcohol an...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1438-7
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Iodine fortification programs have been applied in many iodine deficient regions. Iodine excess is also unfavourable, and it is recommended to monitor iodine status by measuring urinary iodine concentration (UIC). The number of samples needed in such monitoring depends on the variation in UIC. However, it is...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0551-5
更新日期：2014-01-01 00:00:00
abstract：:The purpose of this review was to systematically evaluate the variability of the fatty acid composition of venous cord blood phospholipids in different populations. In an attempt to review published evidence systematically, we found 19 data sets describing fatty acid composition of venous cord blood phospholipids in 1...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-002-0366-2
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:Fruit and vegetable (FV) consumption and salt intake are known dietary influences on blood pressure (BP) in adults, but data on their long-term relevance during growth for later BP are rare. We aimed to examine the independent and concomitant influences of adolescent FV and salt intakes on BP in young adulthood...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aime...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-013-0535-5
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-013-0570-2
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...
journal_title：European journal of nutrition
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更新日期：2021-01-02 00:00:00
abstract：PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...
journal_title：European journal of nutrition
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abstract：BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0403-9
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Bioavailability of fat-soluble vitamins from conventional oral supplements is insufficient in some conditions in which fat digestion and absorption are chronically impaired (e. g. cystic fibrosis). AIM OF THE STUDY:We used a water-soluble form of fatsoluble vitamin E (AQUANOVA solubilisate) to create a nutr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-005-0556-9
更新日期：2006-02-01 00:00:00
abstract：INTRODUCTION:The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their inte...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-018-1695-0
更新日期：2018-12-01 00:00:00
abstract：:Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-012-0331-7
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Although research suggests that antioxidant supplementation can protect against exercise-induced muscle damage and oxidative stress, also delayed post-exercise muscle recovery and hindered adaptation to training were reported in the supplemented athletes. PURPOSE:The purpose of the study was to evaluate the...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-014-0757-1
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1668-3
更新日期：2019-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Reactive oxygen radicals have been implicated in the pathophysiology of many neurologic disorders and brain dysfunctions. Kainic acid has been used as a model agent for the study of neurotoxicity of various excitatory amino acids, since it induces neuronal damage through excessive production of reactive oxyg...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0565-8
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:Intake of specific nutrients has been linked to mental states and various indices of cognitive performance although the effects are often subtle and difficult to interpret. Measurement of so-called objective variables (e.g. reaction times) is often considered to be the gold standard for assessing outcomes in th...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To estimate total sodium (Na) and potassium (K) intake using non-fasting morning urine specimens among Lebanese elementary (6-10 year old) schoolchildren. METHOD:A national cross-sectional study was conducted. A multistage cluster sampling procedure was used to select a representative sample of 1403 healthy ch...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants. M...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0577-8
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-017-1390-6
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-016-1376-9
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The consumption of refined, fructose-enriched food continuously increases and has been linked to development of obesity, especially in young population. Low-grade inflammation and increased oxidative stress have been implicated in the pathogenesis of obesity-related disorders including type 2 diabetes. In this ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1065-0
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To test the effect of three diets in their ability to sustain weight loss and improve type 2 diabetes (T2D) and cardiovascular disease (CVD) risk markers after 18-month intervention. METHODS:Following a ≥8 % weight loss, 131 healthy, overweight/obese (BMI ± SD 31.5 ± 2.6 kg/m2) men (n = 55) and women (n = 76) ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-1116-6
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0043-9
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02331-z
更新日期：2020-07-18 00:00:00
