Abstract:
PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets were weaned at 7 days of postnatal age and fed the control formula milk (NBW-CON and IUGR-CON groups) or the control formula milk supplemented with 1.2 g/kg NAC (IUGR-NAC group) for 14 days (n = 7). The plasma and liver samples were analyzed for the parameters related to hepatic damage, redox status, apoptosis, and autophagy. RESULTS:Compared with the NBW-CON group, IUGR-CON group exhibited increased activities of plasma aminotransferases, increased numbers of apoptotic hepatocytes, as well as higher concentrations of protein carbonyl, malondialdehyde (MDA), microtubule-associated protein 1 light chain 3 beta, and phospholipid-conjugated form (MAP1LC3B-II), along with a decrease in the content of reduced glutathione (GSH). NAC treatment increased GSH content and GSH-to-oxidized GSH ratio in the liver of IUGR-NAC group, most likely owing to the improved activities of γ-glutamine-cysteine ligase, γ-glutamine-cysteine synthetase, and glutathione reductase. The hepatic protein carbonyl and MDA contents were decreased in the IUGR-NAC group compared with the IUGR-CON group. In addition, NAC-treated piglets had an increased content of B cell lymphoma/leukemia 2 protein, whereas a decreased expression level of MAP1LC3B-II in the liver. CONCLUSIONS:NAC may have beneficial effects in improving GSH synthesis and cellular homeostasis in the liver of IUGR suckling piglets.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Zhang H,Su W,Ying Z,Chen Y,Zhou L,Li Y,Zhang J,Zhang L,Wang Tdoi
10.1007/s00394-016-1322-xsubject
Has Abstractpub_date
2018-02-01 00:00:00pages
327-338issue
1eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1322-xjournal_volume
57pub_type
杂志文章abstract:INTRODUCTION:The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women. MATERIALS AND METHODS:A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76-1.42 μM) and 45...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
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abstract:BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...
journal_title:European journal of nutrition
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2011-08-01 00:00:00
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2017-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2014-01-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2019-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2016-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02045-x
更新日期:2020-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1238-5
更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00