Abstract:
PURPOSE:Glucosinolates/isothiocyanates are an established class of naturally occurring chemopreventive agents, a principal mechanism of action being to limit the generation of genotoxic metabolites of chemical carcinogens, as a result of modulation of cytochrome P450 and phase II detoxification enzymes. The objective of this study was to assess whether a glucosinolate-rich extract from Daikon sprouts, containing glucroraphasatin and glucoraphenin, is a potential chemopreventive agent by modulating such enzymes in the liver and lung of rats. METHODS:Rats were exposed to the glucosinolate-rich Daikon extract through the diet, at three dose levels, for 14 days, so that the low dose simulates dietary intake. RESULTS:At the low dose only, a modest increase was noted in the hepatic dealkylations of methoxy-, ethoxy-, pentoxyresorufin and benzyloxyquinoline that was accompanied by elevated expression of CYP1 and CYP3A2 apoprotein levels. In lung, only a modest increase in the dealkylation of pentoxyresorufin was observed. At higher doses, in both tissues, these increases were abolished. At the same low dietary dose, the Daikon extract elevated markedly glutathione S-transferase activity paralleled by rises in GSTα, GSTμ and GSTπ protein expression. An increase was also noted in quinone reductase activity and expression. Finally, glucuronosyl transferase and epoxide hydrolase activities and expression were also up-regulated, but necessitated higher doses. CONCLUSION:Considering the ability of Daikon glucosinolates to effectively enhance detoxification enzymes, in particular glutathione S-transferase, it may be inferred that consumption of this vegetable may possess significant chemopreventive activity and warrants further evaluation through epidemiology and studies in animal models of cancer.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Abdull Razis AF,De Nicola GR,Pagnotta E,Iori R,Ioannides Cdoi
10.1007/s00394-012-0397-2subject
Has Abstractpub_date
2013-04-01 00:00:00pages
1279-85issue
3eissn
1436-6207issn
1436-6215journal_volume
52pub_type
杂志文章abstract:PURPOSE:Concentration of carotenoids in the serum is a biomarker of mainly vegetable and fruit consumption. However, the levels of carotenoids in humans may decline with age and can also depend on body fat, alcohol consumption, and cigarette smoking. METHOD:Food intake and characteristics of 159 randomly chosen women ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0493-y
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or g...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0987-x
更新日期:2016-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0764-1
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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abstract:BACKGROUND:Conifer seeds are used for food preparation in several countries. Aim of the study To assess the lipid-lowering and antiatherogenic properties of maritime pine (Pinuspinaster) seed oil. METHODS:The effects of maritime pine oil supplementation (20% w/w) for 2 weeks were compared to those of coconut and sunfl...
journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0452-z
更新日期:2013-08-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1116-6
更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
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doi:10.1007/s00394-006-0642-7
更新日期:2007-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:European journal of nutrition
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doi:10.1007/s00394-011-0268-2
更新日期:2012-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-04-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could make a difference in acute glycaemic responses. METHODS:In a randomised crossover ...
journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02362-6
更新日期:2020-08-17 00:00:00
abstract:BACKGROUND:Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast. AIM OF THE STUDY:To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region). METHODS:This study involved 57 subjects, 18 to 69 years o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0484-0
更新日期:2004-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0737-5
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption an...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02295-0
更新日期:2020-06-10 00:00:00
abstract:PURPOSE:We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS). METHODS:This study was a secondary analy...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-012-0461-y
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Deficiency of micronutrients is common in refugee populations. OBJECTIVES:Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. METHODS:Two sequential cross-sectional studies were condu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0226-z
更新日期:2012-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0963-5
更新日期:2016-06-01 00:00:00
abstract::Previous studies have demonstrated the anti-inflammatory effect of fructooligosaccharides (FOS) on intestinal inflammation. The aim of the present study was to elucidate whether the colonic fermentation of these carbohydrates is a pre-requisite for this anti-inflammatory activity.With this aim short chain-FOS (SC-FOS)...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0610-2
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:The impact of diet on endurance performance and cognitive function has been extensively researched in controlled settings, but there are limited observational data in field situations. This study examines relationships between nutrient intake and cognitive function following endurance exercise amongst a group o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0364-y
更新日期:2013-03-01 00:00:00