Abstract:
PURPOSE:Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. METHODS:Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans. It was administered daily by gavage to Wistar rats (n = 8), from the 7th day before delivery and for 20 days during lactation, in a concentration of 1.44 × 109 CFU/rat. The dam and pups were weighed and milk was collected at 12th and 19th day for determination of protein, triglycerides, cholesterol and lactose by colorimetric assays. TGF-β1 milk levels were analyzed by ELISA. The mammary glands of rats were removed for histological analysis. To detect statistical differences between the groups, tests of mean differences at a significance level of 5% was performed. RESULTS:Supplementation with L. plantarum L62 resulted in significant higher weight of pups (p < 0.05), with similar weight on dams (p > 0.05). The milk yield was not altered by L. plantarum treatment, but the levels of protein, triglycerides and cholesterol were increased (p < 0.05), with no difference in lactose concentration (p > 0.05). Levels of TGF-β1 were higher in the milk of L. plantarum treatment (p < 0.05). CONCLUSIONS:The treatment of dams at the end of pregnancy and lactation with L. plantarum Lp62 increased nutritional content of milk, probably contributing to the higher weight of the pups. The higher levels of TGF-β1 in the milk, could promote immune benefits to the pups. Further studies in this field are needed to prove the potential use of L. plantarum Lp62 as a probiotic.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Messias GC,Rocha AMN,Santos BMS,Botelho AM,Silva DCA,Porto ES,Dos Anjos ML,Sousa RA,Silva MV,da Rocha TB,de Melo AV,Carneiro MRT,Aguiar NS,Santos PP,de Souza EP,Cruz MP,Marques LM,Rezende RP,Romano CC,Uetanabaro APdoi
10.1007/s00394-018-1628-ysubject
Has Abstractpub_date
2019-04-01 00:00:00pages
1137-1146issue
3eissn
1436-6207issn
1436-6215pii
10.1007/s00394-018-1628-yjournal_volume
58pub_type
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