当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUTRITION期刊下所有文献 > A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

Abstract：

PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. Serum 25(OH)D, parathyroid hormone, calcium, biomarkers of liver and renal function were measured at multiple time points. RESULTS:The mean (SD) serum 25(OH)D at baseline was 31.6 (8.7) nmol/L, and the dose-response relationship was curvilinear with a plateau around 6 weeks for all doses. At week 16, 25(OH)D was increased by 6.0 (6.5), 21.7 (15.8), 26.3 (12.6), 32.0 (12.8) and 36.3 (26.0) nmol/L for 0, 400, 800, 1200 and 2000 IU/d (all P ≤ 0.002), corresponding to approximately 19, 53, 67, 77 and 80 % of reversion of vitamin D deficiency, respectively. Daily intake of 800 IU vitamin D3 reached a targeted 25(OH)D ≥ 30 nmol/L in at least 97.5 % of Chinese, but not a targeted 25(OH)D ≥ 50 nmol/L even with 2000 IU/d. Change of 25(OH)D was inversely associated with change of PTH concentration (r = -0.39, P < 0.001) after controlling for age and sex. No between-group differences were observed in terms of the change in serum calcium, alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and creatinine (P ≥ 0.22). CONCLUSIONS:Supplementation with 400, 800, 1200 or 2000 IU/d vitamin D could improve the vitamin D deficiency with various degrees. Whether 2000 IU/d vitamin D3 would generate a better result without side effect requires more studies with larger samples in future.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Yao P,Lu L,Hu Y,Liu G,Chen X,Sun L,Ye X,Zheng H,Chen Y,Hu FB,Li H,Lin X

doi

10.1007/s00394-015-0859-4

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

383-92

issue

1

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-015-0859-4

journal_volume

55

pub_type

杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF NUTRITION文献大全
  • Seasons but not ethnicity influence urinary iodine concentrations in Belgian adults.

    abstract：BACKGROUND:Mild iodine deficiency (MID) is endemic in Belgium. Previous surveys, which assessed iodine nutrition in Belgium, focused on children. The iodine status of adults and the influence of ethnicity or seasonality on urinary iodine concentrations (UIC) have not been investigated. Since the nutritional profile of ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-010-0137-4

    authors： Moreno-Reyes R,Carpentier YA,Macours P,Gulbis B,Corvilain B,Glinoer D,Goldman S

    更新日期：2011-06-01 00:00:00

  • Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study.

    abstract：BACKGROUND:Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the as...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-009-0065-3

    authors： Rajpathak SN,Freiberg MS,Wang C,Wylie-Rosett J,Wildman RP,Rohan TE,Robinson JG,Liu S,Wassertheil-Smoller S

    更新日期：2010-06-01 00:00:00

  • Iodine status from childhood to adulthood in females living in North-East Italy: Iodine deficiency is still an issue.

    abstract：PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0853-x

    authors： Watutantrige Fernando S,Cavedon E,Nacamulli D,Pozza D,Ermolao A,Zaccaria M,Girelli ME,Bertazza L,Barollo S,Mian C

    更新日期：2016-02-01 00:00:00

  • The effect of three different ad libitum diets for weight loss maintenance: a randomized 18-month trial.

    abstract：PURPOSE:To test the effect of three diets in their ability to sustain weight loss and improve type 2 diabetes (T2D) and cardiovascular disease (CVD) risk markers after 18-month intervention. METHODS:Following a ≥8 % weight loss, 131 healthy, overweight/obese (BMI ± SD 31.5 ± 2.6 kg/m2) men (n = 55) and women (n = 76) ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-015-1116-6

    authors： Due A,Larsen TM,Mu H,Hermansen K,Stender S,Toubro S,Allison DB,Astrup A

    更新日期：2017-03-01 00:00:00

  • The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study).

    abstract：PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-012-0339-z

    authors： Papadopoulou E,Stratakis N,Roumeliotaki T,Sarri K,Merlo DF,Kogevinas M,Chatzi L

    更新日期：2013-02-01 00:00:00

  • Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome.

    abstract：PURPOSE:Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. METHODS:We investigated the effects of a 4-week oral synbiotic treatment (OMN...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1826-7

    authors： Moser AM,Spindelboeck W,Halwachs B,Strohmaier H,Kump P,Gorkiewicz G,Högenauer C

    更新日期：2019-10-01 00:00:00

  • Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet.

    abstract：BACKGROUND:While naturally occurring inulin has anti-hyperlipidemic effects in animals and humans, health effects of synthetic inulin with different degrees of fructose polymerization remain poorly understood. AIM OF THE STUDY:Our study aimed at distinguishing health effects of synthetic inulin with different degrees ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-008-0713-z

    authors： Sugatani J,Osabe M,Wada T,Yamakawa K,Yamazaki Y,Takahashi T,Ikari A,Miwa M

    更新日期：2008-06-01 00:00:00

  • Consumption of wheat bran modified by autoclaving reduces fat mass in hamsters.

    abstract：PURPOSE:To investigate the effect that wheat bran modified by autoclaving (MWB) had on reducing fat accumulation in hamsters fed a hypercholesterolemia- and obesity-inducing diet. METHODS:Male hamsters (n = 45) were randomized into 3 groups and fed a hypercholesterolemia- and obesity-inducing diet with or without 10% ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-013-0583-x

    authors： Harding SV,Sapirstein HD,Rideout TC,Marinangeli CP,Dona AK,Jones PJ

    更新日期：2014-04-01 00:00:00

  • Can changes in hydrophobicity increase the bioavailability of alpha-tocopherol?

    abstract：BACKGROUND:Bioavailability of fat-soluble vitamins from conventional oral supplements is insufficient in some conditions in which fat digestion and absorption are chronically impaired (e. g. cystic fibrosis). AIM OF THE STUDY:We used a water-soluble form of fatsoluble vitamin E (AQUANOVA solubilisate) to create a nutr...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-005-0556-9

    authors： Back EI,Frindt C,Oćenásková E,Nohr D,Stern M,Biesalski HK

    更新日期：2006-02-01 00:00:00

  • A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached.

    abstract：PURPOSE:Higher long-chain polyunsaturated fatty acids (LCP) in infant compared with maternal lipids at delivery is named biomagnification. The decline of infant and maternal docosahexaenoic acid (DHA) status during lactation in Western countries suggests maternal depletion. We investigated whether biomagnification pers...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-011-0245-9

    authors： Luxwolda MF,Kuipers RS,Sango WS,Kwesigabo G,Dijck-Brouwer DA,Muskiet FA

    更新日期：2012-09-01 00:00:00

  • Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort.

    abstract：PURPOSE:Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures re...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02177-5

    authors： Lécuyer L,Dalle C,Micheau P,Pétéra M,Centeno D,Lyan B,Lagree M,Galan P,Hercberg S,Rossary A,Demidem A,Vasson MP,Partula V,Deschasaux M,Srour B,Latino-Martel P,Druesne-Pecollo N,Kesse-Guyot E,Durand S,Pujos-Guillot E

    更新日期：2020-12-01 00:00:00

  • Is heme iron intake associated with risk of coronary heart disease? A meta-analysis of prospective studies.

    abstract：PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aime...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00394-013-0535-5

    authors： Yang W,Li B,Dong X,Zhang XQ,Zeng Y,Zhou JL,Tang YH,Xu JJ

    更新日期：2014-01-01 00:00:00

  • Changes in the serum metabolite profile in obese children with weight loss.

    abstract：PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0698-8

    authors： Reinehr T,Wolters B,Knop C,Lass N,Hellmuth C,Harder U,Peissner W,Wahl S,Grallert H,Adamski J,Illig T,Prehn C,Yu Z,Wang-Sattler R,Koletzko B

    更新日期：2015-03-01 00:00:00

  • In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients.

    abstract：BACKGROUND:Disease preventing effects gained by garlic consumption have been recognized since early period of history, making commercially available garlic supplements attractive to the general public. Possible pharmacokinetic interactions which could occur between applied drugs and aged garlic extract (AGE) are unknow...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-010-0095-x

    authors： Berginc K,Žakelj S,Kristl A

    更新日期：2010-09-01 00:00:00

  • Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial.

    abstract：PURPOSE:Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-015-0982-2

    authors： Libuda L,Mesch CM,Stimming M,Demmelmair H,Koletzko B,Warschburger P,Blanke K,Reischl E,Kalhoff H,Kersting M

    更新日期：2016-06-01 00:00:00

  • No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects.

    abstract：BACKGROUND:High intake of vegetables and fruits is associated with decreased risk of coronary heart disease. Part of these cardioprotective effects may be mediated via the antithrombotic effects of compounds found in vegetables and fruits, such as flavonoids. AIM OF THE STUDY:To study the effects of high and low intak...

    journal_title：European journal of nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00394-004-0456-4

    authors： Freese R,Vaarala O,Turpeinen AM,Mutanen M

    更新日期：2004-06-01 00:00:00

  • Habitual dietary intake of β-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial-ankle pulse wave velocity in healthy adults.

    abstract：PURPOSE:The interaction between genetics and diet may explain the present disagreement in the protective role of vitamin intake on cardiovascular disease. We cross-sectionally assessed the interaction of habitual dietary intake of β-carotene, vitamin C, folate, and vitamin E with single nucleotide polymorphisms (SNPs) ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00394-015-0896-z

    authors： Park CY,Jung S,Kim MK,Choi BY,Shin MH,Shin DH,Lee YH,Chun BY,Hong KW,Hwang JY

    更新日期：2016-03-01 00:00:00

  • Celiac disease: understanding the gluten-free diet.

    abstract：PURPOSE:The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-016-1238-5

    authors： Bascuñán KA,Vespa MC,Araya M

    更新日期：2017-03-01 00:00:00

  • Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults.

    abstract：PURPOSE:Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1713-2

    authors： Yao Z,Gu Y,Zhang Q,Liu L,Meng G,Wu H,Xia Y,Bao X,Shi H,Sun S,Wang X,Zhou M,Jia Q,Wu Y,Song K,Gao W,Guo C,Niu K

    更新日期：2019-03-01 00:00:00

  • Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin.

    abstract：PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0895-0

    authors： Pons Z,Margalef M,Bravo FI,Arola-Arnal A,Muguerza B

    更新日期：2016-03-01 00:00:00

  • Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice.

    abstract：PURPOSE:Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS:COLO205 cells were pretreated with WPE and then stimulated with tu...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1704-3

    authors： Koh SJ,Choi YI,Kim Y,Kim YS,Choi SW,Kim JW,Kim BG,Lee KL

    更新日期：2019-06-01 00:00:00

  • Correction to: Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study.

    abstract：:In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00394-018-1800-4

    authors： Strauss M,Smith W,Kruger R,van der Westhuizen B,Schutte AE

    更新日期：2018-10-01 00:00:00

  • Drinking patterns are associated with variations in atherosclerotic risk factors in French men.

    abstract：BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-005-0567-6

    authors： Rouillier P,Bertrais S,Daudin JJ,Bacro JN,Hercberg S,Boutron-Ruault MC

    更新日期：2006-03-01 00:00:00

  • In vivo and in vitro evidences that carotenoids could modulate the neutrophil respiratory burst during dietary manipulation.

    abstract：BACKGROUND:The primary role of polymorphonuclear neutrophils (PMNs) is to destroy pathogenic microorganisms after phagocytosis by producing reactive oxygen species (ROS) and toxic molecules. However, PMNs produce sufficient amounts of ROS during an oxidative burst to be autotoxic and detrimental to their own functions ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-004-0501-3

    authors： Walrand S,Farges MC,Dehaese O,Cardinault N,Minet-Quinard R,Grolier P,Bouteloup-Demange C,Ribalta J,Winklhofer-Roob BM,Rock E,Vasson MP

    更新日期：2005-03-01 00:00:00

  • Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals.

    abstract：PURPOSE:To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. METHODS:A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingest...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-015-1110-z

    authors： Martín-Peláez S,Castañer O,Konstantinidou V,Subirana I,Muñoz-Aguayo D,Blanchart G,Gaixas S,de la Torre R,Farré M,Sáez GT,Nyyssönen K,Zunft HJ,Covas MI,Fitó M

    更新日期：2017-03-01 00:00:00

  • Macronutrient intake and frailty: the Rotterdam Study.

    abstract：PURPOSE:To investigate the longitudinal association between the macronutrient composition of the diet and frailty. METHODS:Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related defi...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02131-0

    authors： Verspoor E,Voortman T,van Rooij FJA,Rivadeneira F,Franco OH,Kiefte-de Jong JC,Schoufour JD

    更新日期：2020-10-01 00:00:00

  • Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

    abstract：INTRODUCTION:Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties. FACTORS AFFCETING INDIVIDUAL VARIABILITY:The bioavailability of these compounds depends on their free or conjugated presence in food matrices, which is also affected by food proces...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-019-01987-6

    authors： Bento-Silva A,Koistinen VM,Mena P,Bronze MR,Hanhineva K,Sahlstrøm S,Kitrytė V,Moco S,Aura AM

    更新日期：2020-06-01 00:00:00

  • Predicting mixed-meal measured glycaemic index in healthy subjects.

    abstract：PURPOSE:To determine the influence of meal composition on the glycaemic impact of different carbohydrate staples, and the accuracy of "adjusted calculated meal GI" compared with "measured mixed-meal GI". METHODS:In a non-blind randomized crossover trial fasted healthy subjects consumed four dinner-type mixed meals of ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-018-1813-z

    authors： Ballance S,Knutsen SH,Fosvold ØW,Fernandez AS,Monro J

    更新日期：2019-10-01 00:00:00

  • Elevated urinary Na/K ratio among Lebanese elementary school children is attributable to low K intake.

    abstract：PURPOSE:To estimate total sodium (Na) and potassium (K) intake using non-fasting morning urine specimens among Lebanese elementary (6-10 year old) schoolchildren. METHOD:A national cross-sectional study was conducted. A multistage cluster sampling procedure was used to select a representative sample of 1403 healthy ch...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-016-1164-6

    authors： El Mallah C,Merhi K,Ghattas H,Shatila D,Francis S,Hlais S,Toufeili I,Obeid O

    更新日期：2017-04-01 00:00:00

  • A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase.

    abstract：PURPOSE:Glucosinolates/isothiocyanates are an established class of naturally occurring chemopreventive agents, a principal mechanism of action being to limit the generation of genotoxic metabolites of chemical carcinogens, as a result of modulation of cytochrome P450 and phase II detoxification enzymes. The objective o...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-012-0397-2

    authors： Abdull Razis AF,De Nicola GR,Pagnotta E,Iori R,Ioannides C

    更新日期：2013-04-01 00:00:00