Abstract:
BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study compared taste acceptability (measured by the eagerness to eat) and efficacy of soy-based RUTF (S-RUTF) with milk-based RUTF (M-RUTF) in 6- to 59-month-old children suffering from SAM (WHZ < -3) at icddr,b, in Bangladesh. These SAM children were enrolled in the study after completion of their stabilization phase of treatment. Tolerance of test-RUTF was also tested during the efficacy trial. RESULTS:The cross-over taste acceptability study, conducted in 36 children, revealed similar results between products and an absence of side effects. The efficacy trial enrolled 260 children (130, each group) with similar baseline characteristics, including mean ± SD age 15.0 ± 8.0 months, WHZ - 3.41 ± 0.40 and mid-upper arm circumference (MUAC) 11.1 ± 0.7 cm. The features at the end of study by RUTF group were (in S-RUTF vs. M-RUTF, respectively): total days from enrollment: 44 ± 34 versus 39 ± 30; weight gain (kg): 0.698 ± 0.438 versus 0.741 ± 0.381 and rate of weight gain (g/kg/d): 3.9 ± 3.2 versus 5.2 ± 4.6; MUAC gain (cm): 0.9 ± 0.7 versus 0.9 ± 0.6; and improvement of WHZ: 1.12 ± 0.82 versus 1.22 ± 0.68 (all data were man ± SD and none were significantly different between the groups). At enrollment and the end of intervention, the body composition [total body water (TBW): 70.3 ± 3.2 vs. 69.9 ± 3.5%, and fat: 11.0 ± 4.0 vs.11.5 ± 4.3% at baseline; and TBW: 65.5 ± 4.1 vs. 65.9 ± 4.6%; and fat: 16.8 ± 5.2 vs. 16.2 ± 5.8% in S-RUTF and M-RUTF group, respectively] was found similar. Moreover, the increment of total TBW, FM, and FFM was also observed similar between the groups. CONCLUSIONS:This is the first randomized trial comparing S-RUTF using soy protein isolate with milk-based RUTF including comparison of body composition. S-RUTF was found equally acceptable as of milk-based RUTF without any adverse event. Children receiving S-RUTF showed similar pattern of changes in anthropometric indices, and body composition as of milk-based RUTF. Greater number of SAM children can be managed in the community with comparatively low-cost soy-based RUTF. TRIAL REGISTRATION:NCT01634009.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Hossain MI,Huq S,Islam MM,Ahmed Tdoi
10.1007/s00394-019-01975-wsubject
Has Abstractpub_date
2020-04-01 00:00:00pages
1149-1161issue
3eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-01975-wjournal_volume
59pub_type
杂志文章,随机对照试验abstract::Nutrition trends in Europe are driven by taste, health and convenience. The possibilities of research using new technologies and tools such as nutrigenomics, imaging techniques, nanotechnology, bioinformatics, cognitive sciences, innovative processes are very promising to support these nutrition trends and in particul...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-009-0076-0
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-012-0395-4
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:The interaction between genetics and diet may explain the present disagreement in the protective role of vitamin intake on cardiovascular disease. We cross-sectionally assessed the interaction of habitual dietary intake of β-carotene, vitamin C, folate, and vitamin E with single nucleotide polymorphisms (SNPs) ...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-015-0896-z
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0853-x
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes. AIM OF THE STUDY:We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0778-3
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:This study aimed to assess the dietary patterns of adolescents using a food-based diet quality index and their compliance with a healthy dietary guideline METHODS: Participants included 71,553 Brazilian adolescents (12-17 years old) from the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectiona...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-019-01923-8
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract::In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...
journal_title:European journal of nutrition
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00394-018-1800-4
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02382-2
更新日期:2020-09-10 00:00:00
abstract::Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0579-2
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast. AIM OF THE STUDY:To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region). METHODS:This study involved 57 subjects, 18 to 69 years o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0484-0
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS:This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was c...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1449-4
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0204-5
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Epidemiological studies directly examining the association between habitual yoghurt consumption and mental health remain scarce. The aim of this study is to investigate the association of yoghurt consumption with depressive symptoms in adults. METHODS:This is a cross-sectional study of 19,596 Chinese adults (m...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1532-x
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The fat mass and obesity-associated gene (FTO) is related to obesity and coronary heart disease (CHD). We studied interaction between macronutrient intake and FTO in association with CHD risk or body mass index (BMI). METHODS:The pooled population-based case-control studies, SHEEP and INTERGENE, included 1,381...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0842-0
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:The contribution of extra virgin olive oil (EVOO) macro- and micro-constituents in heart oxidative and inflammatory status in a hypercholesterolemic rat model was evaluated. Fatty acid profile as well as α-tocopherol, sterol, and squalene content was identified directly in rat hearts to distinguish the effect o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0947-5
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0895-0
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1396-0
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Current evidence accounts for the role of (poly)phenolic compounds in the prevention of non-communicable diseases. Detailed information on population-level intakes is required to translate these findings into recommendations. This work aimed to estimate (poly)phenol intake in the UK population using data from a...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1862-3
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,0...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02159-2
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Excessive consumption of soft drinks is associated with nonalcoholic fatty liver disease (NAFLD). However, the association between soft drinks consumption and NAFLD is unclear in non-Caucasian adults with relatively low soft drinks consumption. The aim of this study was to assess the association between soft dr...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1485-0
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS:This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1883-y
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Advanced glycation end products (AGEs) formed in food during high-heat cooking may induce overeating and inflammation. We investigated whether AGE contents in a single meal affect postprandial appetite and markers of inflammation, endothelial activation, and oxidative stress. METHODS:In total, 19 healthy overw...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-013-0574-y
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0859-4
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM:To test the acute effects of a lunch containing capsaicin on gut de...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0006-1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1793-z
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1390-6
更新日期:2018-04-01 00:00:00
abstract:AIM:To evaluate the preventive and therapeutic effects of Lactobacilluscasei Zhang on impaired glucose tolerance (IGT) by using fructose-induced hyperinsulinemia rats. METHODS:Rats were fed 25 % fructose solution for hyperinsulinemia with L.casei Zhang for prevention or therapy. Serum levels of insulin, glucagon-like ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0519-5
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-003-0421-7
更新日期:2003-10-01 00:00:00