Abstract:
PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined. METHODS:The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks. Sham-operated rats had the same diet as OVX-Control (Normal-Control). Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined. Gut microbiota in the fecal samples was measured by NGS and analyzed with PICRUSt2. Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry. RESULTS:Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production. OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control. Both alleviated dyslipidemia, compared to the OVX-Control. OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations. In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis. OVX-Pectin exhibited increased α-diversity in the fecal bacteria. Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05). CONCLUSION:Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria. Chitosan was more effective for improving menopausal symptoms than citrus pectin.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Wu X,Kim MJ,Yang HJ,Park Sdoi
10.1007/s00394-020-02382-2subject
Has Abstractpub_date
2020-09-10 00:00:00eissn
1436-6207issn
1436-6215pii
10.1007/s00394-020-02382-2pub_type
杂志文章abstract:PURPOSE:Cordyceps sinensis has been regarded as a precious tonic food and herbal medicine in China for thousands of years. The exopolysaccharide (EPS) from an anamorph of Cordyceps sinensis was found to have antitumor immunomodulatory activity. Mature dendritic cells play a role in initiating antitumor immunity, so we ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0373-x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole populat...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0691-6
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1793-z
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wi...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0904-3
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathophysiology of NASH is u...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-018-1721-2
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1390-6
更新日期:2018-04-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. José M. Gámez was not listed among the authors. ...
journal_title:European journal of nutrition
pub_type: 已发布勘误
doi:10.1007/s00394-020-02433-8
更新日期:2020-12-05 00:00:00
abstract:PURPOSE:Fruit and vegetable (FV) consumption and salt intake are known dietary influences on blood pressure (BP) in adults, but data on their long-term relevance during growth for later BP are rare. We aimed to examine the independent and concomitant influences of adolescent FV and salt intakes on BP in young adulthood...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0804-y
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:Osteoporosis is associated with both lower health-related quality of life and depression in older people. We examined the independent and combined effects of a multi-component exercise program and calcium-vitamin D3 fortified milk on health-related quality of life (HR-QoL) and depression in older men. METHODS:...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-01969-8
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bac...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-012-0415-4
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0859-4
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects' total polyphenol intake and their mortality from all cau...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02136-9
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:To describe the patterns of ultra-processed foods (UPFs) consumption in the Netherlands; to test if exposure to the food environment is associated with UPFs consumption; and if this association differed across educational levels and neighbourhood urbanisation. METHODS:Cross-sectional study using 2015-data of 8...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02436-5
更新日期:2020-11-24 00:00:00
abstract:PURPOSE:Epidemiological studies directly examining the association between habitual yoghurt consumption and mental health remain scarce. The aim of this study is to investigate the association of yoghurt consumption with depressive symptoms in adults. METHODS:This is a cross-sectional study of 19,596 Chinese adults (m...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1532-x
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:European journal of nutrition
pub_type: 信件
doi:10.1007/s00394-018-1700-7
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasm...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02126-x
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Extensive exercise may promote the formation of reactive oxygen species and subsequently contribute to tissue damage. A compound which can protect cells and tissues is vitamin E. The vitamin E radical, formed during the radical scavenging process, can be reduced by vitamin C resulting in a higher level of th...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-003-0414-6
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1482-3
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The primary role of polymorphonuclear neutrophils (PMNs) is to destroy pathogenic microorganisms after phagocytosis by producing reactive oxygen species (ROS) and toxic molecules. However, PMNs produce sufficient amounts of ROS during an oxidative burst to be autotoxic and detrimental to their own functions ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0501-3
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02282-5
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Although a role of glycemic index (GI) and glycemic load (GL) in age-related cataract development is plausible, a few studies, all conducted in USA or Australia, provided results on this issue. The aim of the present study was to provide new original data from a Mediterranean population. METHODS:We analyzed da...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-014-0731-y
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Organic acids from plant food have been shown to play an important role in the prevention of chronic diseases (osteoporosis, obesity), inherent to western diets, but little is known about their bioavailability in the small intestine, information that needs to be determined in order to quantify likely effec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0112-0
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The antiatherogenic activity of pomegranate juice has been attributed to its antioxidant polyphenols. The most potent in vitro antioxidant polyphenol from this juice is the ellagitannin punicalagin. However, the bioavailability of ellagitannins, including punicalagin, has not been previously described in hum...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0461-7
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1668-3
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0895-0
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1079-7
更新日期:2017-02-01 00:00:00
abstract::The purpose of this review was to systematically evaluate the variability of the fatty acid composition of venous cord blood phospholipids in different populations. In an attempt to review published evidence systematically, we found 19 data sets describing fatty acid composition of venous cord blood phospholipids in 1...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-002-0366-2
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-012-0395-4
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Reactive oxygen radicals have been implicated in the pathophysiology of many neurologic disorders and brain dysfunctions. Kainic acid has been used as a model agent for the study of neurotoxicity of various excitatory amino acids, since it induces neuronal damage through excessive production of reactive oxyg...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0565-8
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1385-3
更新日期:2018-04-01 00:00:00