Abstract:
PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syndrome (MS). METHODS:Male 8-week-old Wistar rats were fed cafeteria or standard (ST) diet for 10 weeks. After this, the antihypertensive effect of a single oral administration of a polyphenol grape seed extract (GSPE) was tested at different doses (250, 375 and 500 mg/kg) in CHRs. BP was recorded before and 2, 4, 6, 8, 24 and 48 h post-administration. The hypotensive effect of GSPE was also proved in ST diet-fed rats. Additionally, in other experiment, CHRs were orally administered 375 mg/kg GSPE. Four hours post-administration, the rats were intraperitoneally administrated 30 mg/kg NG-nitro-L-arginine methyl ester (L-NAME) or 5 mg/kg indomethacin [inhibitors of nitric oxide (NO) and prostacyclin synthesis, respectively]. BP was recorded initially and 6 h post-administration. RESULTS:GSPE produced a decrease in SBP and DBP, the most effective dose (375 mg/kg) showing an antihypertensive effect in CHRs similar to the drug captopril, and did not affect BP of ST diet-fed rats. The antihypertensive effect was completely abolished by L-NAME and partially inhibited by indomethacin. CONCLUSIONS:GSPE acts as an antihypertensive agent in a rat model of hypertension associated with MS. The change in endothelium-derived NO availability is one of the mechanisms involved in the antihypertensive effect of GSPE in CHRs. Additionally, endothelial prostacyclin contributes to the effect of GSPE on arterial BP.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Pons Z,Margalef M,Bravo FI,Arola-Arnal A,Muguerza Bdoi
10.1007/s00394-015-0895-0subject
Has Abstractpub_date
2016-03-01 00:00:00pages
749-758issue
2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0895-0journal_volume
55pub_type
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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更新日期:2013-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
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更新日期:2020-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1639-8
更新日期:2018-08-01 00:00:00
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journal_title:European journal of nutrition
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更新日期:2017-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00