Abstract：
BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel trial. METHODS:Three groups (n=12/group) of healthy, normolipemic male and female subjects with a mean baseline serum lycopene concentration of 0.36 micro mol/L took a dose of 15 mg/day total lycopene for 28 days from either Lycovit 10% (beadlets, BASF, Germany) or Lyc-O-Mato (beads, LycoRed Natural Products, Israel) or a placebo (without lycopene) together with the main meal. The increase in serum lycopene from baseline was used as the parameter of bioavailability. RESULTS:Synthetic and tomato-lycopene resulted in significant increases above baseline of serum total lycopene by 0.58 and 0.57 micro mol/L, trans-lycopene by 0.34 and 0.41 micro mol/L, and total-cis-lycopene by 0.24 and 0.16 micro mol/L, whereas no significant changes were found in the placebo treatment. The mean serum total lycopene response to synthetic and natural lycopene was not significantly different. Neither lycopene source affected the other serum carotenoids, viz. alpha-carotene, beta-carotene, beta-cryptoxanthin, zeaxanthin and lutein. CONCLUSION:We conclude that synthetic and natural lycopene are equivalent sources of lycopene and that there is no interaction with other circulating carotenoids.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Hoppe PP,Krämer K,van den Berg H,Steenge G,van Vliet Tdoi
10.1007/s00394-003-0421-7keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
272-8issue
5eissn
1436-6207issn
1436-6215journal_volume
42pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants. METHODS:We included 2611 participants that were born at term from a Dutch population-based b...
journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2018-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
abstract：PURPOSE:Inadequate iodine intake may result in iodine deficiency disorders (IDD). Thus, for more than 50 years, policies for the regulation of salt fortification with iodine have existed in Brazil. In 2003, a study on 6-14-year-old schoolchildren from regions of the state of São Paulo showed a median urinary iodine con...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2017-03-01 00:00:00
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journal_title：European journal of nutrition
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更新日期：2011-02-01 00:00:00
