Abstract:
INTRODUCTION:The prevention of Alzheimer's disease (AD) has become a real challenge due to its rising prevalence and the lack of an effective cure. Diet and nutrients have gained significant interest as potentially modifiable protective factors. PURPOSE:The aim of this review is to provide an updated summary of evidence related to the effect of diet and nutritional factors on the risk of AD and cognitive aging, and discuss the potential mechanisms and confounding factors involved. METHODS:A search was conducted in Medline and Web of Knowledge for epidemiological and clinical studies in the international literature from January 2000 to February 2013 using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3", "antioxidants", "B vitamins", "dietary patterns", and "Mediterranean diet". RESULTS AND CONCLUSION:Data from observational studies point to a protective role for certain nutrients, such as omega-3 fatty acids, antioxidants or B vitamins, and dietary patterns (Mediterranean diet). However, data from randomized controlled trials do not show a consistent effect. Whether confounding factors such as age, disease stage, other dietary components, cooking processes, and other methodological issues explain the divergent results remains to be established. Moreover, if certain nutrients protect against dementia, it is as yet unknown whether they may have a general effect on brain vascular health or directly interfere with the etiopathogenesis of AD.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Otaegui-Arrazola A,Amiano P,Elbusto A,Urdaneta E,Martínez-Lage Pdoi
10.1007/s00394-013-0561-3subject
Has Abstractpub_date
2014-02-01 00:00:00pages
1-23issue
1eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章,评审abstract:PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-012-0395-4
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:In our previous study, we demonstrated that diallyl trisulfide (DATS) induced iron-dependent G2-M arrest of prostate cancer cell cycle. Moreover, ferritin degradation and an increase of labile iron pool has been linked to the activation of the JNK signaling axis. In the present work, we extended this study to d...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0241-0
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Poor sperm quality is a major contributor to infertility in heterosexual couples, but at present there are few empirical therapies. Several studies have examined the role of dietary factors and data from randomized controlled trials suggest that oral antioxidant therapy can improve some sperm parameters. Health...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-02091-5
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-indu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0358-9
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02158-3
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Rooibos tea (Aspalathus linearis) is commonly used for hyperactive gastrointestinal, respiratory and cardiovascular disorders. AIM OF STUDY:The aqueous extract of Rooibos tea (RT) was studied for the possible bronchodilator, antispasmodic and blood pressure lowering activities in an attempt to rationalize s...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0620-0
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Epidemiological studies directly examining the association between habitual yoghurt consumption and mental health remain scarce. The aim of this study is to investigate the association of yoghurt consumption with depressive symptoms in adults. METHODS:This is a cross-sectional study of 19,596 Chinese adults (m...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1532-x
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her ...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1238-5
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Dietary polyphenols have been studied for their potential effects on metabolic disorders, but studies on risk of hypertension are scarce. This study aimed to test the association between total and individual classes of dietary polyphenols and incidence of hypertension in the Polish arm of the Health, Alcohol an...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1438-7
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids. OBJECTIVE:To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1036-5
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1275-0
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Vitamin A deficiency induces activation of NF-kB and impairs activities of antioxidant enzymes in aorta. AIM OF THE STUDY:We study the effect of vitamin A deficiency on the aorta histoarchitecture and the possibly contribution of its prooxidant and inflammatory effects to artery alterations. METHODS:Twenty...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1864-1
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Atherosclerosis is known to be an inflammatory disease. Dendritic cells (DCs) are essential for the regulation of the immune system. Up to 10% of the cells in atherosclerotic plaques are DCs. The cardiovascular protective effects of flavonoids (tea, wine) may be mediated by anti-inflammatory mechanisms that aff...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0125-8
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:Epidemiologic data linking adherence to the dietary approaches to stop hypertension (DASH) diet and metabolic abnormalities is sparse and inconsistent. The association between habitual intake of the DASH diet and metabolic syndrome (MetS) has not been investigated in the Middle East. We aimed to determine wheth...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0723-y
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The study of vitamin D status at population level gained relevance since vitamin D deficiency was recently suggested to trigger chronic disease. AIM OF THE STUDY:We aimed to describe vitamin D status, its association with bone and mineral metabolism and risk factors for deficiency in adults over 40 years in...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0756-1
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women. MATERIALS AND METHODS:A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76-1.42 μM) and 45...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s00394-012-0377-6
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:The transcription factor NF-kappaB is suggested to play a pivotal role in atherogenesis by regulating the expression of proinflammatory gene products such as adhesion molecules. Garlic is consumed as food or dietary supplement in order to benefit from its antiatherogenic effect. AIM OF THE STUDY:This study ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0437-7
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS:This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1883-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability. AIM OF THE STUDY:To investigate the effects of citric acid addition, phytase treatment and supplementation...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-006-0637-4
更新日期:2007-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0245-9
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Enhanced tryptophan degradation via the kynurenine pathway has been related to several pathological conditions. However, little is known about the effect of diet on individual metabolites of this pathway. We investigated cross-sectional associations between reported intake of fish and omega-3 (n-3) long-chain P...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1077-9
更新日期:2017-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-07-18 00:00:00
abstract::In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...
journal_title:European journal of nutrition
pub_type: 杂志文章,已发布勘误
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更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To provide a new and efficient at-the-toilet-bowl method of self-assessing urine concentration via urine color (Uc) to identify hypohydration. METHODS:A large athletic population (n = 189) delivered a urine sample, then chose a color panel that was displayed on the back wall of the lavatory stall. Selection wa...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2021-01-08 00:00:00