Abstract:
PURPOSE:Poor sperm quality is a major contributor to infertility in heterosexual couples, but at present there are few empirical therapies. Several studies have examined the role of dietary factors and data from randomized controlled trials suggest that oral antioxidant therapy can improve some sperm parameters. Health benefits of lycopene supplementation have been proposed for a variety of health conditions and here we examine whether it can help improve sperm quality. This study aimed to investigate the effect of 14 mg daily lactolycopene for 12 weeks on semen quality in healthy men. METHODS:Sixty healthy male participants were recruited and randomized to this double-blind, placebo-controlled parallel study and received either 14 mg/d lactolycopene or a placebo for 12 weeks. The primary endpoint was a change in motile sperm concentration. Secondary endpoints were all other aspects of sperm quality, including the level of sperm DNA damage. RESULTS:Fifty-six men completed the intervention and the level of plasma lycopene was significantly increased in the men randomized to receive lycopene supplementation. There was no significant change in the primary endpoint (motile sperm concentration) post-intervention (p = 0.058). However, the proportion of fast progressive sperm (p = 0.006) and sperm with normal morphology (p < 0.001) did improve significantly in response to lactolycopene intervention. CONCLUSIONS:Supplementation with 14 mg/d lactolycopene improves sperm motility and morphology in young healthy men. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE:ISRCTN33248724 http://www.isrctn.com/ISRCTN33248724.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Williams EA,Parker M,Robinson A,Pitt S,Pacey AAdoi
10.1007/s00394-019-02091-5subject
Has Abstractpub_date
2020-03-01 00:00:00pages
825-833issue
2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-02091-5journal_volume
59pub_type
杂志文章,随机对照试验abstract:PURPOSE:Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. METHODS:We investigated the effects of a 4-week oral synbiotic treatment (OMN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1826-7
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:The secoiridoid oleuropein, as found in olives and olive leaves, modulates some biomarkers of diabetes risk in vivo. A possible mechanism may be to attenuate sugar digestion and absorption. METHODS:We explored the potential of oleuropein, prepared from olive leaves in a water soluble form (OLE), to inhibit dig...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-018-1662-9
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To assess the effectiveness of a dietary intervention combined with fortified dairy products on bone metabolism and bone mass indices in postmenopausal women. METHODS:Forty postmenopausal women (55-65 years old) were equally randomized into a dietary group (DG), receiving daily and for 30 months, 1,200 mg of c...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-010-0142-7
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To explore whether changes in dietary protein sources can lower plasma branched-chain amino acids (BCAAs), aromatic amino acids and sulfur amino acids (SAAs) that are often elevated in the obese, insulin-resistant state and in type 2 diabetes. METHODS:Thirty-six subjects (mean age 31 ± 2 years) underwent a vol...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. METHODS:Lactobacillus plantarum L...
journal_title:European journal of nutrition
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更新日期:2019-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract:PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wi...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Experimentally imposed dietary restriction is known to extend the lifespan of rodents, perhaps by slowing the accumulation of oxidative damage that is thought to be one of the causes of aging. AIM OF THE STUDY:We examined the effects of restricted total food intake, and protein and calorie restriction, on D...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0520-0
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:While the prevalence of children on vegetarian diets is assumed to be on the rise in industrialized countries, there are hardly any representative data available. In general, vegetarian diets are presumed to be healthy; nevertheless, there are concerns as to whether the dietary specifications required during in...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-017-1416-0
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02451-6
更新日期:2021-01-02 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0095-x
更新日期:2010-09-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02240-1
更新日期:2020-04-10 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0691-6
更新日期:2008-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0452-z
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-08-17 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0653-z
更新日期:2007-06-01 00:00:00
abstract:AIM:To evaluate the preventive and therapeutic effects of Lactobacilluscasei Zhang on impaired glucose tolerance (IGT) by using fructose-induced hyperinsulinemia rats. METHODS:Rats were fed 25 % fructose solution for hyperinsulinemia with L.casei Zhang for prevention or therapy. Serum levels of insulin, glucagon-like ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0519-5
更新日期:2014-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1079-7
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Few studies have evaluated the association of fruit and vegetable (FV) intake and pre-diabetes. However, these studies are very limited and incomplete. Therefore, the aim of our study was to compare FV consumption and their subgroups between pre-diabetic and control subjects. METHODS:This case-control study in...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Amaranth is a crop that can be grown in different soils and climates, being resistant to high temperatures, drought, and some pests. The amaranth plant has nutritional qualities and desirable biological properties. AIM OF THE STUDY:The aim of the study is to investigate the potential antitumor properties of...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
abstract:PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0567-6
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0339-z
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1385-3
更新日期:2018-04-01 00:00:00