Abstract：
PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mechanisms of action of TXER against NAFLD/NASH progression to hepatocarcinogenesis. METHODS:The effect of TXER (12.5, 25 or 50 mg/kg b.w/day) was evaluated on the nitrosodiethylamine (NDEA) model of hepatocarcinogenesis in rats, after 16 weeks of oral treatment, with special focus on liver specific enzymes, xenobiotic metabolizing enzymes, antioxidant status, lipid peroxidation profile, DNA damage, fibrosis, cell proliferation and inflammatory status. RESULTS:Administration of TXER to hepatocellular carcinoma-bearing rats restored the enzyme activities and the hepatic architecture. Furthermore, TXER significantly curtailed NDEA-induced DNA damage, cell proliferation, inflammation, fibrosis and hepatic hyperplasia. CONCLUSION:This study provides the evidence that troxerutin exerts a significant therapeutic effect against liver cancer by modulating liver function enzymes, xenobiotic enzymes, oxidative damage, inhibiting cell proliferation, suppressing inflammatory response and induction of apoptosis.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Thomas NS,George K,Arivalagan S,Mani V,Siddique AI,Namasivayam Ndoi
10.1007/s00394-016-1275-0subject
Has Abstractpub_date
2017-10-01 00:00:00pages
2353-2366issue
7eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1275-0journal_volume
56pub_type
杂志文章abstract：BACKGROUND AND AIM:Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM r...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0542-6
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The combined hyperglycemia lowering and antioxidant actions of α-lipoic acid (LA) contribute to its usefulness in preventing renal injury and other diabetic complications. The precise mechanisms by which LA alters diabetic oxidative renal injury are not known. We hypothesized that LA through its hypoglycemic ef...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0452-z
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-013-0570-2
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can i...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02382-2
更新日期：2020-09-10 00:00:00
abstract：BACKGROUND:Due to their lower glycaemic index, leguminous seeds affect human carbohydrate metabolism lesser than do cereals. Problems, however, could arise from side effects, e.g., increasing flatulence. AIM OF THE STUDY AND METHODS:In 26 healthy subjects, metabolic and symptomatic responses following acute ingestion ...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s003940050060
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1396-0
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Childhood obesity is a widespread and growing problem in the world. Body mass index (BMI) and weight-for-height criterion have been used to determine childhood obesity. No data was available to evaluate cardiovascular risk factors in overweight and obese Chinese children screened by weight-for-height index a...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0718-7
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal int...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1004-0
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Although a role of glycemic index (GI) and glycemic load (GL) in age-related cataract development is plausible, a few studies, all conducted in USA or Australia, provided results on this issue. The aim of the present study was to provide new original data from a Mediterranean population. METHODS:We analyzed da...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-014-0731-y
更新日期：2015-04-01 00:00:00
abstract：:Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-012-0331-7
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aime...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-013-0535-5
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption an...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02295-0
更新日期：2020-06-10 00:00:00
abstract：PURPOSE:It is unclear if midlife consumption of dairy and soy food intake, and their components of calcium and isoflavones (in soy), is related to cognitive impairment in elderly. METHODS:We used baseline data on lifestyle and habitual diet of 16,948 participants collected during their recruitment into the Singapore C...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02010-8
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1713-2
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS). METHODS:This study was a secondary analy...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-012-0461-y
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretio...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1644-y
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1149-x
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between al...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-018-1613-5
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Vitamin A deficiency induces activation of NF-kB and impairs activities of antioxidant enzymes in aorta. AIM OF THE STUDY:We study the effect of vitamin A deficiency on the aorta histoarchitecture and the possibly contribution of its prooxidant and inflammatory effects to artery alterations. METHODS:Twenty...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0198-z
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1385-3
更新日期：2018-04-01 00:00:00
abstract：:The purpose of this review was to systematically evaluate the variability of the fatty acid composition of venous cord blood phospholipids in different populations. In an attempt to review published evidence systematically, we found 19 data sets describing fatty acid composition of venous cord blood phospholipids in 1...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-002-0366-2
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:To examine whether a body shape index (ABSI) calculated by using waist circumference (WC) adjusted for height and weight could improve the predictive performances for cardiovascular disease (CVD) of the Framingham's general CVD algorithm and to compare its predictive performances with other anthropometric measu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0833-1
更新日期：2016-02-01 00:00:00
abstract：PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0594-7
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:Diabetes is a chronic inflammatory disorder resulting in endothelial dysfunction which contributes to peripheral arterial disease and limb ischemia. Leukocytes play critical roles in vascular and tissue remodelling after ischemia. This study investigated the effects of dietary glutamine (GLN) supplementation on...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01951-4
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:This study aimed to assess the effects of folic acid (FA) combined with a docosahexaenoic acid (DHA) intervention on the cognitive function and inflammatory cytokines in elderly subjects with mild cognitive impairment (MCI). METHODS:This randomized, double-blind, placebo-controlled trial recruited 240 individu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02373-3
更新日期：2020-08-28 00:00:00
abstract：PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1079-7
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:Increasing evidence suggests the potential use of natural antioxidant compounds in the prevention/treatment of osteoporosis. This study was undertaken to investigate the effects of purified delphinidin-3-rutinoside (D3R), isolated from Solanum melongena L., on osteoblast viability and differentiation in basal c...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1618-0
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Individuals with favorable levels of readily measured cardiovascular disease (CVD) risk factors (low risk, LR) experience low long-term rates of CVD mortality and greater longevity. The purpose of the current study was to compare nutrient/food intakes of LR participants with participants not LR in the INTERMAP ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0268-2
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:L-Theanine is the major free amino acid present in tea (Camellia sinensis L.). The effects of several tea constituents on male reproduction have been investigated, but L-theanine has been overlooked. Sertoli cells (SCs) are essential for the physical and nutritional support of germ cells. In this study, we aime...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01999-2
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:A recent prospective cohort study revealed that moderate wine consumption but not consumption of other alcoholic beverages is associated with a decreased risk of common cold. In contrast, wine constituents such as ethanol and polyphenols are known to suppress immunity. AIM OF THE STUDY:We investigated wheth...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-002-0384-0
更新日期：2002-12-01 00:00:00
