Abstract:
PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption and biovailability of dietary hydroxytyrosol and the influence of the dietary food-containing hydroxytyrosol on it. METHODS:A double-blind study was performed including 20 volunteers who ingested 5 mg of hydroxytyrosol through diverse food matrices, to discover the influence on pharmacokinetics and bioavailability of HT metabolites (hydroxytyrosol acetate, 3,4-dihydroxyphenylacetic acid (DOPAC), tyrosol, and homovanillic alcohol) of the distinct matrices by UHPLC-ESI-QqQ-MS/MS. RESULTS:The HT pharmacokinetics after consumption of different food matrices was strongly dependent on the food matrix. In this aspect, the intake of extra virgin olive exhibited significantly higher plasma concentrations after 30 min of oral intake (3.79 ng/mL) relative to the control. Regarding the hydroxytyrosol bioavailability, the intake of extra virgin olive oil, as well as fortified refined olive, flax, and grapeseed oils provided significantly higher urinary contents (0.86, 0.63, 0.55, and 0.33 µg/mg creatinine, respectively) compared with basal urine, whereas hydroxytyrosol metabolites showed no significant changes. No differences were found between men and women. CONCLUSIONS:The metabolic profile of hydroxytyrosol is influenced by the food matrix in which is incorporated, with the oily nature for the final bioavailability being relevant. Extra virgin olive oil was identified as the best matrix for this compound. The results described contribute to the understanding of the relevance of the food matrices for the final absorption of hydroxytyrosol and hence, the achievement of the highest health protection potential.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Alemán-Jiménez C,Domínguez-Perles R,Medina S,Prgomet I,López-González I,Simonelli-Muñoz A,Campillo-Cano M,Auñón D,Ferreres F,Gil-Izquierdo Ádoi
10.1007/s00394-020-02295-0subject
Has Abstractpub_date
2020-06-10 00:00:00eissn
1436-6207issn
1436-6215pii
10.1007/s00394-020-02295-0pub_type
杂志文章abstract:BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for stu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s003940070016
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:Nicotinic acid is one of the older drugs used to treat hyperlipidemia, the greatest risk factor of coronary heart disease. Nicotinic acid is also a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD). In mammals, α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) plays a key role in NA...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0547-1
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given that the UGN-GUCY2C system has been proposed as a novel...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0869-2
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. METHODS:A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingest...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1110-z
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Protein-restricted diet during pregnancy is related to oxidative stress and, as a consequence, damage to nephrogenesis. We investigated the effects of vinifera grape skin extract (ACH09)-derived polyphenols on preserving renal morphology of maternal protein-restricted 1-day-old offspring. METHODS:Female C57/Bl...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0963-5
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Deficiency of micronutrients is common in refugee populations. OBJECTIVES:Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. METHODS:Two sequential cross-sectional studies were condu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0226-z
更新日期:2012-06-01 00:00:00
abstract::Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0579-2
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0698-8
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. METHODS:We investigated the effects of a 4-week oral synbiotic treatment (OMN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1826-7
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:Rebalancing the contribution of animal- and plant-based foods is needed to achieve sustainable diet. However, little is known concerning individual characteristics that may influence intake of plant-based foods and their changes over time. We aimed to assess changes in the contribution of plant-based foods to d...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1752-8
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Reactive oxygen radicals have been implicated in the pathophysiology of many neurologic disorders and brain dysfunctions. Kainic acid has been used as a model agent for the study of neurotoxicity of various excitatory amino acids, since it induces neuronal damage through excessive production of reactive oxyg...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0565-8
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could make a difference in acute glycaemic responses. METHODS:In a randomised crossover ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02083-5
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1385-3
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue. METHODS:We performed a me...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析
doi:10.1007/s00394-014-0662-7
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:There are limited data on the contribution of fortified foods and nutritional supplements to intakes of vitamin D in young children. Our objective was to examine the intake, adequacy, risk of excessive intake and sources of dietary vitamin D. METHODS:The nationally representative cross-sectional dietary survey...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1171-7
更新日期:2017-04-01 00:00:00
abstract::The potential impact on health of diets rich in free sugars, and particularly fructose, is of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity, and the associated risk of developing type 2 diabetes. Much of the concern is focussed on specific metabolic effects of ...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1340-8
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Several factors can affect glycemic and insulinemic responses from cereal foods. Some suggested factors lowering the responses are; intact botanical structure, high amylose/high ss-glucan cereal varieties, organic acid produced during fermentation and food processes inducing retrogradation of starch. AIM OF...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0724-9
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1322-x
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1149-x
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To describe total fluid intake (TFI) and types of fluid consumed in urban China by age, gender, regions and city socioeconomic status relative to the adequate intakes (AI) set by the Chinese Nutrition Society. METHODS:In 2016, participants aged 4-9, 10-17 and 18-55 years were recruited via a door-to-door appro...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1755-5
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive br...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1337-3
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02426-7
更新日期:2020-11-04 00:00:00
abstract:PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02331-z
更新日期:2020-07-18 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Organic acids from plant food have been shown to play an important role in the prevention of chronic diseases (osteoporosis, obesity), inherent to western diets, but little is known about their bioavailability in the small intestine, information that needs to be determined in order to quantify likely effec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0112-0
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:A recent prospective cohort study revealed that moderate wine consumption but not consumption of other alcoholic beverages is associated with a decreased risk of common cold. In contrast, wine constituents such as ethanol and polyphenols are known to suppress immunity. AIM OF THE STUDY:We investigated wheth...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-002-0384-0
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1793-z
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Vegetables and fruits are rich sources of a variety of nutrients, including vitamins (E and C), trace minerals, and dietary fibers, and many other classes of biologically active compounds such as carotenoids and polyphenols, which are often assumed to protect against degenerative pathologies such as cardiova...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0594-y
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability. AIM OF THE STUDY:To investigate the effects of citric acid addition, phytase treatment and supplementation...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-006-0637-4
更新日期:2007-03-01 00:00:00