Abstract:
BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal intake of different proportions of n-6/n-3 fatty acids on colon inflammation in the young adult rats. METHODS:Female Wistar rats were assigned into four groups, and each group fed one of four semisynthetic diets, namely n-6, low n-3, n-6/n-3 and n-3 fatty acids for 8 weeks prior to mating, during gestation and lactation periods. At weaning, the pups were separated from the dams and fed diet similar to the mothers. Colitis was induced on postnatal day 35, by administering 2 % dextran sulfate sodium in drinking water for 10 days. Colitis was assessed based on the clinical and inflammatory markers in the colon. Fatty acid analysis was done in liver, RBC, colon and spleen. RESULTS:A balanced n-6/n-3 PUFA diet significantly improved the body weight loss, rectal bleeding and mortality in rats. This was associated with lower myeloperoxidase activity, nitric oxide, prostaglandin E2, TNF-α and IL-6, IL-8, COX-2 and iNOS levels in the colon tissues. Fatty acid analysis has shown that the arachidonic acid/docosahexaenoic acid ratio was significantly lower in liver, RBC, colon and spleen in n-6/n-3 and n-3 diet groups. CONCLUSION:We demonstrate that balanced n-6/n-3 PUFA supplementation in maternal and neonatal diet alters systemic AA/DHA ratio and attenuates colon inflammation in the young adult rats.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Reddy KV,Naidu KAdoi
10.1007/s00394-015-1004-0subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1875-90issue
5eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-1004-0journal_volume
55pub_type
杂志文章abstract:BACKGROUND:Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. AIM OF THE STUDY:A relationship between basal level of antioxidants (vit...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0642-7
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability. AIM OF THE STUDY:To investigate the effects of citric acid addition, phytase treatment and supplementation...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-006-0637-4
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognit...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1029-4
更新日期:2016-09-01 00:00:00
abstract::The awareness is increasing that in the colon many metabolic processes take place in relation to the fermentation of our food, which might be relevant for health and disease. However, the relation between food, colon metabolism and health or disease is far from clear. In this overview, the physiology of colonic metabo...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-002-1101-8
更新日期:2002-11-01 00:00:00
abstract::The objective of this study was to assess the effect of conjugated linoleic acid isomers (CLAs) on the expression and activity of phospholipases A(2) (PLA(2)) in human macrophages. Macrophages were incubated with 30 microM cis-9, trans-11 and trans-10, cis-12 CLAs for 48 h. After incubation, the total activity of phos...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0626-7
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-012-0395-4
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:This study was aimed to determine the impact of hydroxytyrosol (HT), a minor compound found in olive oil, on breast cancer stem cells (BCSCs) and the migration capacity of triple-negative breast cancer (TNBC) cell lines through the alteration of epithelial-to-mesenchymal transition (EMT) and embryonic signaling...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1864-1
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline,...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1220-2
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To examine whether a body shape index (ABSI) calculated by using waist circumference (WC) adjusted for height and weight could improve the predictive performances for cardiovascular disease (CVD) of the Framingham's general CVD algorithm and to compare its predictive performances with other anthropometric measu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0833-1
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0567-6
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To investigate the effect that wheat bran modified by autoclaving (MWB) had on reducing fat accumulation in hamsters fed a hypercholesterolemia- and obesity-inducing diet. METHODS:Male hamsters (n = 45) were randomized into 3 groups and fed a hypercholesterolemia- and obesity-inducing diet with or without 10% ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0583-x
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1322-x
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Reports on the protective effect of a Mediterranean diet on mortality usually refer to populations from Mediterranean countries, leaving uncertain whether really diet is the fundamental cause. Our aim was to examine the effect of a Mediterranean diet on mortality in Switzerland, a country combining cultural inf...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0695-y
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast. AIM OF THE STUDY:To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region). METHODS:This study involved 57 subjects, 18 to 69 years o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0484-0
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:To estimate total sodium (Na) and potassium (K) intake using non-fasting morning urine specimens among Lebanese elementary (6-10 year old) schoolchildren. METHOD:A national cross-sectional study was conducted. A multistage cluster sampling procedure was used to select a representative sample of 1403 healthy ch...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1164-6
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her ...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1238-5
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02395-x
更新日期:2020-10-01 00:00:00
abstract::Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-014-0654-7
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND AIM:Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM r...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0542-6
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Extensive exercise may promote the formation of reactive oxygen species and subsequently contribute to tissue damage. A compound which can protect cells and tissues is vitamin E. The vitamin E radical, formed during the radical scavenging process, can be reduced by vitamin C resulting in a higher level of th...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-003-0414-6
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:Ellagitannins are high molecular weight polyphenols present in high quantities in various food products. They are metabolized by human and animal gut microbiota to postbiotic metabolites-urolithins, bioavailable molecules of a low molecular weight. Following absorption in the gut, urolithins rapidly undergo pha...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02386-y
更新日期:2020-09-22 00:00:00
abstract:PURPOSE:The effect of 40 μg (1,600 IU) per day of vitamin D(3) on serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism was evaluated. METHODS:This intervention study was designed as a double-blind randomised controlled trial. Forty-five community-dwelling subjects (32 females), age 55-84 year...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-011-0271-7
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Choline-containing dietary phospholipids, including phosphatidylcholine (PC), may function as anti-inflammatory substances, but the mechanism remains largely unknown. We investigated the effects of L-alpha-glycerylphosphorylcholine (GPC), a deacylated PC derivative, in a rodent model of small intestinal ischaem...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0691-2
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic c...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s00394-011-0189-0
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids. OBJECTIVE:To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1036-5
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:Our aim was to characterize the effect of an unfamiliar high-fat diet (HFD) on circadian feeding behaviour, plasma parameters, body weight (BW), and gene expression in the prefrontal cortex (PFC) of adolescent male mice. To this end, mice were allowed to consume a HFD during 48 h, but one group was allowed a fr...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1225-x
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0775-z
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS:This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1883-y
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Global DNA hydroxymethylation is markedly decreased in human cancers, including hepatocellular carcinoma, which is associated with chronic alcohol consumption and aging. Because gene-specific changes in hydroxymethylcytosine may affect gene transcription, giving rise to a carcinogenic environment, we determined...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1098-4
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1713-2
更新日期:2019-03-01 00:00:00